Center for InVivo Imaging and Therapy Shared Resources Core

InVivo 成像和治疗中心共享资源核心

基本信息

批准号：
9883740
负责人：
Walter John Akers
金额：
$ 26.21万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9883740
关键词：
Adrenal Glands Anatomy Animal Model Animals Basic Science Biology Biomedical Engineering Blood Brain Neoplasms Brain Stem Cancer Center Support Grant Cancer Model Cancer Research Project Cells Cerebellum Child Childhood Solid Neoplasm Clinical Management Clinical Treatment Clinical Trials Clonality Collaborations Consultations Country Data Disease Drug Kinetics Ensure Excision Exposure to Fluorescence Frequencies Funding Genetic Goals Heterogeneity Image Image-Guided Surgery Imaging technology Implant Injections Institution Journals Liver Location Magnetic Resonance Imaging Malignant Neoplasms Measurement Medicine Methods Microscope Modeling Monitor Mus Nature New England Operative Surgical Procedures Patients Pemetrexed Play Pre-Clinical Model Publications Radiation Research Research Personnel Research Support Resource Sharing Resources Role Scientist Services Solid Neoplasm Spleen Strategic Planning Surveys System Technical Expertise Technology Therapeutic Therapeutic Studies Therapy trial Translating Treatment Protocols Tumor Biology Tumor Tissue Tumor Volume Ultrasonography Validation Veterinarians Work Xenograft Model Xenograft procedure animal imaging anticancer research base bioimaging bioluminescence imaging cancer cell cancer imaging cancer therapy chemotherapy clinically relevant efficacy study experience experimental study gemcitabine high standard image guided image guided radiation therapy image guided therapy imaging capabilities imaging modality implantation improved in vivo in vivo imaging indexing ineffective therapies instrumentation leukemia medulloblastoma member microCT microPET minimally invasive model development multiphoton microscopy pre-clinical pre-clinical research pre-clinical therapy precision medicine preclinical imaging preclinical study preclinical trial programs treatment response tumor tumor growth tumor xenograft

项目摘要

PROJECT SUMMARY/ABSTRACT— Center for In Vivo Imaging and Therapeutics The Center for In Vivo Imaging and Therapeutics (CIVIT) is an SJCCC-managed Shared Resource with the overarching goal of providing cutting-edge imaging and image-guided therapy technologies to advance preclinical cancer modeling research. As part of the SJCCC Strategic Plan, the HMP, DBSTP, NBTP, and CBP prioritized enhanced animal modeling as a central requirement for their preclinical research endeavors, with CIVIT at the center of these plans. CIVIT plays a major role in advancing SJCCC preclinical research by offering leading surgical and imaging expertise, allowing Program members to readily model and survey genetic and orthotopic-implant models of brain tumors, solid tumors, and leukemias. CIVIT partners with SJCCC members to provide consultative and technical expertise in modeling and conducting experiments for their preclinical research. The core also offers seminars to educate users about new preclinical imaging applications and technologies. CIVIT is directed by Dr. Walter Akers, an NCI R50-funded veterinarian and biomedical engineer with more than 11 years of experience in cancer imaging and therapy research. He is supported by 1 staff scientist and 6 highly skilled research technologists to provide imaging, surgery, and therapeutic services, and partner with SJCCC groups in planning and performing experiments to ensure animal studies are conducted at the highest standard. The impact of the CIVIT on the cancer research of the Programs is evidenced by the high level of collaborative publications and key scientific contributions in high-impact journals such as Blood (n=5), Nature Genetics (n=3), and Cancer Cell (n=6). During the current funding period, 66 publications from January 2013–December 2017 used the CIVIT, representing 28 (42%) interprogrammatic and 33 (50%) intraprogrammatic collaborations. These included publications from 4 of the 5 Programs: DBSTP (n=16), HMP (n=25), CBP (n=34), and NBTP (n=25). During the index year (FY2017), 94% of all investigators using the CIVIT were SJCCC members (49/52). Goals for the next period include upgrading high-frequency ultrasounds (Vevo 3100, Visualsonics) to provide state-of-the-art capabilities for image-guided injections and tumor volume measurement; obtaining a fluorescence-capable surgical microscope to optimize brainstem O-PDX implantation and image-guided resections of O-PDX tumors in mice; and upgrading the IGRT system with BLI capability (Muriglo, Xstrahl) to enable tumor-selective radiation for preclinical trials. These advanced technologies will ensure continued high-level support of the preclinical research of the SJCCC Programs.

项目摘要/摘要——体内成像和治疗中心体内成像和治疗中心 (CIVIT) 是 SJCCC 管理的共享资源，总体目标是提供尖端的成像和图像引导治疗技术以推进作为 SJCCC 战略计划、HMP、DBSTP、NBTP 和 CBP 的一部分，临床前癌症模型研究。优先考虑增强动物模型作为其临床前研究工作的核心要求， CIVIT 是这些计划的核心，通过提供服务，在推进 SJCCC 临床前研究方面发挥着重要作用。领先的外科和成像专业知识，使计划成员能够轻松建模和调查遗传和 CIVIT 与 SJCCC 成员合作开发脑肿瘤、实体瘤和白血病的原位植入模型。为其临床前模型和实验提供咨询和技术专业知识该核心还提供研讨会来教育用户新的临床前成像应用和 CIVIT 由 NCI R50 资助的兽医和生物医学工程师 Walter Akers 博士领导。在癌症成像和治疗研究方面拥有超过 11 年的经验，他由 1 名工作人员提供支持。科学家和 6 名高技能研究技术人员提供成像、手术和治疗服务，以及与 SJCCC 小组合作规划和进行实验，以确保动物研究在 CIVIT 对癌症研究的高标准可见一斑。高影响力期刊（例如《Blood》）中的合作出版物和关键科学贡献水平（n=5）， Nature Genetics (n=3) 和 Cancer Cell (n=6) 在当前资助期内，1 月份发表了 66 篇论文。 2013 年至 2017 年 12 月使用了 CIVIT，代表 28 个 (42%) 项目间项目和 33 个项目 (50%) 其中包括 5 个计划中 4 个计划的出版物：DBSTP (n=16)、HMP (n=25)、CBP (n=34) 和 NBTP (n=25) 在索引年（2017 财年），94% 的调查人员使用 CIVIT。是 SJCCC 成员 (49/52) 下一阶段的目标包括升级高频超声 (Vevo)。 3100，Visualsonics）提供最先进的图像引导注射和肿瘤体积功能测量；获得具有荧光功能的手术显微镜以优化脑干 O-PDX 植入小鼠 O-PDX 肿瘤的图像引导切除，并升级具有 BLI 功能的 IGRT 系统；（Muriglo，Xstrahl）这些先进技术将使肿瘤选择性放射能够用于临床前试验。确保 SJCCC 项目的临床前研究得到持续的高层支持。