COBRE for Reproductive Health

COBRE 促进生殖健康

• 批准号: 9883799
• 负责人: SURENDRA SHARMA
• 金额: $ 241.95万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883799
• 关键词: Advisory Committees; Basic Science; Biology; Biostatistics Core; Cardiovascular Diseases; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Investigator; Clinical Management; Collaborations; Communities; Core Facility; Data; Diabetes Mellitus; Discipline of obstetrics; Disease; Elderly; Ensure; Environment; Etiology; Extramural Activities; Faculty; Female; Fostering; Funding; Future; Gestational Diabetes; Goals; Health; Hospitals; Infant; Infrastructure; Institution; Intervention; Knowledge; Leadership; Life; Life Cycle Stages; Maternal Health; Mediating; Mentors; Metabolic; Metabolic Diseases; Metabolic syndrome; Mothers; Neonatal Intensive Care; New England; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Outcome; Oxygen; Pathway interactions; Patients; Physiological; Pilot Projects; Pre-Clinical Model; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Rate; Premature Birth; Publishing; Reproductive Biology; Reproductive Health; Reproductive Medicine; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Rhode Island; Risk; Scientist; Stress Tests; Talents; Technology; Time; Training; Translational Research; United States National Institutes of Health; Vision; Woman; Women' s Health; adverse pregnancy outcome; biomedical referral center; career; career development; clinically significant; data management; early pregnancy; experience; fetal; high risk; improved; innovation; insight; multidisciplinary; nervous system disorder; offspring; predictive marker; premature; programs; recruit; reproductive; response; translational research program

SUMMARY / ABSTRACT Pregnancy is a critically important time in a woman's life and it is recognized as a window into women's future health. Although the overwhelming majority of patients have a healthy outcome, pregnancy complications have been on the rise globally. New and emerging data strongly suggest significant maternal health consequences after pregnancies complicated by preeclampsia, diabetes and preterm birth. Likewise, offspring born to mothers experiencing these conditions are at significant risk of developing chronic diseases, including neurological, metabolic, and cardiovascular disorders. Surprisingly, the causes of these pregnancy-associated disorders have remained enigmatic as have prediction and treatment. The programmatic and scientific goals of this Center of Biomedical Research Excellence (COBRE) for Reproductive Health are to develop research infrastructure for a center that supports a multidisciplinary, translational, and innovative program in women's reproductive health. The response to women's reproductive health requires a broad and balanced research strategy aimed at expanding knowledge and technology in reproductive medicine. The overarching research goals of this COBRE application include the use of well-defined pre-clinical models to understand mechanisms mediating preeclampsia, gestational diabetes and prematurity, identification of functional predictive biomarkers, and application of contemporary computational approaches to enhance our understanding of the networks and pathways underlying these devastating pregnancy complications. The proposed projects are hypothesis-driven and supported by strong published and preliminary data. An outstanding group of scientists will serve as Mentors to the Investigators and the Internal Advisory Committee and External Advisory Committee (to be formed) will provide timely guidance and oversight for the program. This COBRE for Reproductive Health includes four talented investigators as Project Leaders supported by Administrative, Clinical and Translational, and Data Management and Biostatistics Cores. The COBRE will also support two pilot projects per year. The Specific Aims of this COBRE are: 1. Establish an integrated research community to provide leadership in basic and translational research in reproductive biology and medicine; 2. Support the career trajectories of talented junior investigators in reproductive health to ensure their successful transition to established investigators; 3. Build infrastructure for reproductive research through support for the Clinical and Translational Core and the Data Management and Biostatistics Core. The Research Projects will also leverage existing core facilities supported by the institution; and 4. Maintain recruitment of promising Junior Investigators committed to research on reproductive health and provide mentoring by established investigators.

摘要 /摘要 怀孕是女人一生中至关重要的时期，它被认为是进入妇女未来的窗口 健康。尽管绝大多数患者的结局都健康，但妊娠并发症已有 在全球范围内上升。新的和新兴的数据强烈表明孕产妇健康后果 怀孕后，先兆子痫，糖尿病和早产。同样，后代天生 经历这些疾病的母亲有患慢性疾病的巨大风险，包括 神经，代谢和心血管疾病。令人惊讶的是，这些妊娠相关的原因 与预测和治疗一样，疾病仍然是神秘的。编程和科学目标的 这个生殖健康的生物医学研究中心（COBRE）正在发展研究 为支持多学科，翻译和创新计划的中心基础设施 妇女的生殖健康。对妇女生殖健康的反应需要广泛而平衡 旨在扩大生殖医学知识和技术的研究策略。总体 该毛绒应用的研究目标包括使用定义明确的临床前模型来理解 介导先兆子痫，妊娠糖尿病和早产的机制，功能鉴定 预测性生物标志物以及当代计算方法的应用来增强我们的 了解这些毁灭性妊娠并发症的网络和途径。这 拟议的项目是由假设驱动的，并由强大的发布和初步数据支持。一个 杰出的科学家小组将担任研究人员和内部咨询委员会的导师 外部咨询委员会（将要成立）将为该计划提供及时的指导和监督。 这款用于生殖健康的毛绒包括四名才华横溢的调查员，因为项目负责人支持 行政，临床和转化，数据管理与生物统计学核心。毛绒会 还支持每年两个试点项目。该毛绒的具体目的是：1。建立一个集成的 研究社区在生殖生物学基础和转化研究方面提供领导 药品; 2。支持才华横溢的少年研究人员在生殖健康方面的职业轨迹，以确保 他们成功地过渡到既定的调查人员； 3。建立基础设施以通过 支持临床和转化核心以及数据管理和生物统计学核心。这 研究项目还将利用机构支持的现有核心设施；和4。维护 招募有前途的初级调查人员，致力于研究生殖健康并提供 由成熟的调查人员进行指导。