Development of hydraulically fractured oil and natural gas sites and incidence of atrial fibrillation claims in Colorado's All Payer Claims Database

科罗拉多州所有付款人索赔数据库中水力压裂石油和天然气站点的开发以及心房颤动索赔的发生率

• 批准号: 9883051
• 负责人: Lisa Marie McKenzie
• 金额: $ 11.66万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883051
• 关键词: Address; Air Pollution; Area; Arrhythmia; Atrial Fibrillation; Blood Pressure; Blood Vessels; Cerebrovascular Disorders; Cohort Studies; Colorado; Crossover Design; Data; Databases; Development; Diagnosis; Economically Deprived Population; Elderly; Embolism; Environmental Risk Factor; Epidemiology; Etiology; Fracture; Future; Gases; General Population; Goals; Health; Heart failure; Impairment; Incidence; Information Systems; Interruption; Link; Measures; Methods; Morbidity - disease rate; Natural Gas; Oils; Outcome; Patients; Persons; Population; Prevention; Prospective Studies; Quality of life; Resources; Risk; Series; Site; Testing; Thromboembolism; Thrombosis; Time; Woman; Work; arterial stiffness; clinically significant; course development; design; experience; mortality; noise pollution; prospective; stroke risk

Project Summary/Abstract Atrial fibrillation (AF) is the most common and clinically significant cardiac arrhythmia and results in impaired quality of life and substantially elevated risks for stroke, systemic thromboembolism and heart failure. Our preliminary data indicates that people living near HFOG well sites may experience increases in blood pressure and arterial stiffness that are associated with AF. The development of hydraulically fractured oil and natural gas (HFOG or “fracking”) well sites is associated with two emerging environmental risk factors for AF, air and noise pollution. While this evidence indicates that AF patients who reside in close proximity to the development complications, is if the air and noise pollution that occur during the development of HFOG well sites contribute to the etiology and burden of AF. We lack the preliminary data necessary to justify and efficiently design the prospective study will be necessary to address the pressing need to understand these etiological relationships. Without this preliminary data, we are unable to advance methods to investigate the temporal relationships between environmental risks related to HFOG well sites and AF. Our long-term goal is to understand the epidemiological relationships between environmental risks associated with HFOG and AF related health outcomes. The overall objective for this proposal is to link the Colorado All Payer's Claim Database (APCD) and the Colorado O&G Information system (COGIS) to obtain the preliminary data necessary to justify and inform the design of a comprehensive cohort study. To meet this objective, we will employ a longitudinal interrupted time-series crossover design to retrospectively follow ~ 2500 AF patients in the APCD living within 1.6 kilometers (1-mile) of 830 HFOG well sites developed between 2010 and 2015. Our central hypothesis is that there is an increased risk of AF and AF associated morbidity during development of a HFOG well site to which women, the elderly, and those with pre-existing health conditions are more susceptible. We will determine and compare the incidence of claims with a principle diagnosis of AF and AF related mortality in AF patients living within 1.6 km of a HFOG well site before, during, and after development of the site. The proposed study will be the first to evaluate relationships between the development of HFOG well sites and AF related morbidity. Findings from our study will allow us to determine if a cohort study is warranted and if warranted, inform the design of such a study. This future study would prospectively follow populations for AF and related morbidity over the course of development of HFOG well sites while measuring specific environmental risk factors associated with this development. Considering the rapidly growing number of people living in close proximity to an HFOG well set, it is essential that we work to understand the associated health risks as soon as possible so that we can develop the best preventions and remedies for those people. of HFOG sites may be at a significantly greater risk for additional incidents of AF and associated it is not known

项目摘要/摘要 心房颤动（AF）是最常见且具有临床意义的心律不齐，并导致受损 生活质量以及中风，全身性血栓栓塞和心力衰竭的风险大大提高。我们的 初步数据表明，住在HFOG井站附近的人们可能会升高血压 与AF相关的动脉刚度。水解油和天然的发展 天然气（HFOG或“压裂”）井站点与AF，空气和 噪声污染。虽然该证据表明，与居住在附近的AF患者 发展 并发症是在HFOG开发过程中发生的空气和噪声污染是否 站点有助于AF的病因和燃烧。我们缺乏证明和 有效设计前瞻性研究是必要的，以应对理解这些的紧迫需求 病因关系。没有这些初步数据，我们将无法提出研究 与HFOG井站点和AF有关的环境风险之间的临时关系。我们的长期目标是 了解与HFOG和AF相关的环境风险之间的流行病学关系 相关的健康结果。该提案的总体目标是将科罗拉多州所有付款人的主张联系起来 数据库（APCD）和科罗拉多州O＆G信息系统（COGIS）获取初步数据 为了证明和告知全面研究研究的设计所必需的。为了实现这一目标，我们将 员工是纵向中断的时间序列跨界设计，可追溯约2500名AF患者 在2010年至2015年间，居住在830 Hfog井站点的1.6公里（1英里）以内的APCD居住在1.6公里（1英里）之内。 中心假设是在开发过程中发生AF和AF相关的发病率的风险增加 HFOG井井网站，妇女，老年人和患有健康状况的妇女越来越多 易受影响的。我们将确定和比较主张的事件与AF和AF的原则诊断 开发前，期间和之后，生活在HFOG井站1.6公里以内的AF患者的相关死亡率 网站。拟议的研究将是第一个评估HFOG发展之间关系的研究 井站点和与AF相关的发病率。我们研究的发现将使我们能够确定队列研究是否是 有必要并保证，请告知此类研究的设计。这项未来的研究可能会遵循 在测量HFOG井站点的发展过程中，AF和相关发病率的人群 与此发展相关的特定环境风险因素。考虑迅速增长的数量 在靠近HFOG良好设置的人们中，我们必须努力了解 尽快有相关的健康风险，以便我们可以为 那些人。 HFOG站点可能面临着AF和相关事件的其他事件的风险明显更大 这是不知道的