Advanced Skills Development in Glyco-Hematology and Glyco-Oncology

糖血液学和糖肿瘤学高级技能发展

• 批准号: 9751362
• 负责人: Umesh Ramanlal Desai
• 金额: $ 12.26万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751362
• 关键词: Achievement; Address; Applications Grants; Area; Attention; Biochemistry; Biological Markers; Biological Response Modifier Therapy; Biology; Blood; Blood Cells; Blood Coagulation Factor; Blood Proteins; Cardiovascular Diseases; Cell Separation; Cells; Chemistry; Clinical; Development; Diagnostic; Disease; Doctor of Philosophy; Educational Activities; Educational process of instructing; Future; Future Generations; Glycosaminoglycans; Hematology; Heparin; Human; Human Biology; Knowledge; Laboratories; Literature; Low-Molecular-Weight Heparin; Malignant Neoplasms; Medicine; Milk; Molecular Weight; National Research Council; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacology; Pharmacy Students; Plasma; Polysaccharides; Postdoctoral Fellow; Procedures; Program Development; Property; Proteins; Recombinants; Reporting; Research; Research Personnel; Research Technics; Role; Scientist; Stem cells; Structure; Techniques; Technology; Therapeutic; Trademark; Training; Training Programs; Translational Research; United States National Academy of Sciences; Universities; Work; cancer cell; cancer stem cell; career; education planning; education research; experience; graduate student; hands on research; innovation; interest; oncology; programs; protein B; research and development; skill acquisition

 DESCRIPTION (provided by applicant): The 2012 National Research Council (NRC) report titled `Transforming Glycoscience: A Roadmap for the Future' from the National Academy of Sciences, USA states that "Relatively little attention has been paid to this class of molecules, and glycoscience remains a relatively understudied field". The current RFA HL-15-006 attempts to address this state through development of creative educational activities that focus on "research area related to blood research, clinical procedures for research, or specialized research techniques. [e.g.] techniques for blood glycoscience, ... stem cell isolation/handling techniques " (see Section 1 of the RFA). In this grant application, we propose a skills development program that relies on a combination of didactic courses and hands-on research to train future generation scientists with expertise in the glycosciences of importance to hematology and oncology. Our program focuses on understanding structural and functional aspects of a) low and ultralow molecular weight heparins (LMWHs & ULMWHs) and b) N/O-glycans (NOGs) of blood proteins/cells. We proposed to 1) develop a research education plan that combines didactic teaching, literature analysis and hands-on research to train a cadre of graduate students and postdocs in the areas of glyco-hematology and glyco-oncology; 2) develop innovative research modules on structural and functional characterization of LMWHs/ULMWHs (modules 1 and 2) and NOGs of coagulation factors (module 3) and cancer stem cells (module 4); and 3) disseminate results and achievement in both skills development and research to enhance the impact of glycosciences in the biological and therapeutic arena. The combination of the teaching program proposed here with four highly innovative research modules is expected to impart the value of glycoscience to the young trainees, while also generating substantial new knowledge, technology and translational science that advances their careers. A distinguishing point about our program is its pharmaceutical/therapeutic (or translational) relevance. (End of Abstract)

 描述（由适用提供）：2012年国家研究委员会（NRC）的报告，标题为“转化性糖科学：未来的路线图”，来自美国国家科学院，美国指出：“对这类分子的关注很少，而糖科学的关注相对较少，而糖科学仍然是一个相对了解的领域”。当前的RFA HL-15-006试图通过开发创造性的教育活动来解决这种状态，该活动重点是“与血液研究，研究或专业研究技术有关的研究领域。在此赠款应用程序中，我们提出了一项技能开发计划，该计划依靠教学课程和动手研究的结合，以培训具有重要性血液学和肿瘤学糖基因群专业知识的未来一代科学家。我们的计划着重于理解a）血液蛋白/细胞的低和超低分子量肝素（LMWHS和ULMWHS）和b）N/O-聚糖（NOGS）。我们建议1）制定一项研究教育计划，该计划结合了教学教学，文献分析和动手研究，以在Glyco-Herasology和Glyco-Concology领域培训一群研究生和博士后的干部；关于LMWHS/ULMWH（模块1和2）以及凝结因子（模块3）和癌症干细胞（模块4）结构和功能表征的创新研究模块； 3）在技能发展和研究中传播结果和成就，以增强糖基镜在生物学和治疗领域的影响。在这里提出的教学计划与四个高度创新的研究模块的结合预计将赋予年轻学员的血糖价值，同时还产生了促进其职业发展的大量新知识，技术和转化科学。关于我们计划的一个区别是其药物/治疗（或翻译）相关性。 （抽象的结尾）