Pre-doctoral Training Program in Integrative Vascular Biology

综合血管生物学博士前培训项目

• 批准号: 9210167
• 负责人: Christopher P. Mack
• 金额: $ 41.85万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9210167
• 关键词: Biology; Blood Vessels; Training Programs; pre-doctoral; Biology; Blood Vessels; Training Programs; pre-doctoral

Program Abstract The complexity of cardiovascular disease has hindered our understanding of its deveopment and progression. To uncover the uncover the mechanisms by which genetic variation and environmental factors influence cardiovascular development and disease, the next generation of scientists will need to be trained to use a variety of approaches, technologies and model systems. In response to this demand the Integrative Vascular Biology (IVB) Pre-doctoral Training Program was established at UNC in 2002 to promote a collaborative interdisciplinary training environment for pre-doctoral students in the cardiovascular field. The IVB Program combines the breadth and depth of the cardiovascular research faculty with other research strengths at UNC in genetic model systems, state-of-the-art cell biology and imaging, high throughput genomic and proteomic analyses, and computational biology. The overall goal of the IVB Program is to provide Trainees with the interdisciplinary and collaborative skills necessary to extend their thesis work into new, innovative, and productive directions. Specific Aim 1 is to connect Trainees in broad areas of cardiovascular research by requiring them to collaborate with secondary mentors outside of their field. This training mechanism was specifically designed to “connect” graduate students in broad areas of cardiovascular biology and cardiovascular health research. The program teaches students to apply molecular, cellular, genetic, and computational approaches to pathological and physiological questions in cell, organ, and whole animal systems; to merge hypothesis- and discovery-based research; and to develop high-throughput approaches for use in complex models. Specific Aim 2 is to provide Trainees with a broad understanding of cardiovascular development and disease. This will be achieved through advanced paper-based cardiovascular courses, cardiovascular seminars by leaders in the field, and through bi-weekly student-led discussion groups. Specific Aim 3 is to enhance the skills necessary for effective collaboration and career advancement. Trainees will improve their communication skills by presenting their work at formal and informal IVB events and students will attend IVB Workshops on grant writing, career development, and scientific rigor and responsibility. The IVB Program is administered by UNC McAllister Heart Institute and is directed by Dr. Christopher Mack (Associate Professor of Pathology) a respected vascular biologist who has been heavily involved in graduate student training at multiple levels.. He is assisted by Co-directors Nobuyo Maeda (Professor of Pathology) and Vicki Bautch (Professor of Biology) and by the advice of executive and advisory committeees made up of well- established senior vascular biologist. A major strength of the Program is the breadth and diversity of the 39 primary training faculty who are committed to graduate student training and who are using cutting edge approaches to answer a wide variety of cardiovascular questions. In summary, with an outstanding history in cardiovascular biology research, a strong group of investigators centered around the MHI, a well-developed academic program in Cardiovascular Science, a large pool of well-qualified applicants, and research excellence in genetic model systems, cell biology, and computational biology, the UNC Integrative Vascular Biology Program offers an outstanding environment for multidisciplinary training of pre-doctoral students.

程序摘要 心血管疾病的复杂性阻碍了我们对其发展和发展的理解。 揭示遗传变异和环境因素影响的机制 心血管发育和疾病，需要对下一代科学家进行培训以使用 各种方法，技术和模型系统。响应这种需求，综合血管 生物学（IVB）博士前培训计划于2002年在UNC建立，以促进协作 心血管领域中博士前学生的跨学科培训环境。 IVB程序 将心血管研究教师的广度和深度与UNC的其他研究优势结合在一起 遗传模型系统，最先进的细胞生物学和成像，高通量基因组和蛋白质组学 分析和计算生物学。 IVB计划的总体目标是为受训者提供 将论文工作扩展到新的创新，跨学科和协作技能， 和产品方向。特定目标1是在心血管研究的广泛领域连接学员 通过要求他们与领域外的二级导师合作。这种训练机制是 专门设计的，用于“连接”心血管生物学广泛领域的研究生 心血管健康研究。该计划教学生应用分子，细胞，遗传和 细胞，器官和整个动物中病理和物理问题的计算方法 系统；合并假设和基于发现的研究；并开发高通量方法 在复杂模型中使用。特定目标2是为受训者提供对心血管的广泛了解 发展与疾病。这将通过基于高级纸质的心血管课程来实现 该领域的领导者以及每两周的学生主导的讨论小组的心血管半手。具体的 目标3是提高有效的合作和职业发展所需的技能。学员会 通过在正式和非正式的IVB活动中介绍他们的工作来提高他们的沟通能力，学生将 参加有关赠款写作，职业发展以及科学严谨和责任的IVB研讨会。 IVB 计划由Unc McAllister Heart Institute管理，由Christopher Mack博士（同事）执导。 病理学教授）一位受人尊敬的血管生物学家，他参与研究生 多个级别的培训。 Bautch（生物学教授）以及由高管和咨询委员会的建议 建立的高级血管生物学家。该计划的主要优势是39 致力于研究生培训并使用尖端的小学培训教师 回答各种心血管问题的方法。总而言之，有着悠久的历史 心血管生物学研究，一群以MHI为中心的强大研究人员，一个发达的人 心血管科学学术计划，大量合格的申请人和研究 遗传模型系统，细胞生物学和计算生物学方面的卓越性 生物学计划为博士前学生的多学科培训提供了一个杰出的环境。