Social Cues and Drug Relapse

社会暗示和药物复发

• 批准号: 9245436
• 负责人: Michael T Bardo
• 金额: $ 21.31万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9245436
• 关键词: Beer; Behavioral; Brain; Brain Diseases; Brain region; Cells; Chronic; Cocaine; Cues; Discrimination; Drug abuse; Drug usage; Environment; Exposure to; Extinction (Psychology); FOS Protein; FOS gene; Female; Goals; Individual; Intervention; Laboratories; Light; Lighting; Measures; Modeling; Odors; Patient Self-Report; Pattern; Pharmaceutical Preparations; Pharmacotherapy; Play; Pre-Clinical Model; Predisposing Factor; Prevention strategy; Procedures; Process; Rattus; Relapse; Reporting; Role; Saline; Self Administration; Self-Administered; Sex Characteristics; Syringes; System; Tactile; Testing; Time; Training; Treatment Efficacy; Visual; Work; cocaine use; community setting; craving; deviant; disorder later incidence prevention; drug abuser; drug maintenance; drug relapse; experimental study; immunoreactivity; male; peer; pre-clinical; psychosocial; relating to nervous system; response; skills; social; treatment program

PROJECT SUMMARY One of the most difficult problems facing drug abuse practitioners is the continuing high rate of relapse following treatment. While there are multiple internal states and external cues that may trigger relapse, one common factor is to re-associate with drug-using social peers. Although some recent preclinical work has examined the role of social influence on acquisition and maintenance of drug self-administration, there is essentially no information about the role of social cues in reinstatement of drug seeking. The overall hypothesis of this project is that self-administering social peers will serve as a cue to induce drug seeking in a controlled preclinical laboratory setting. Separate from discrete cues (light, tone) and contextual cues (tactile and visual cues, time of day), these studies will determine if social peers also are able to reinstate extinguished responding for drug. In addition, these studies will provide definitive information about the potential interactive effects of social and contextual cues in reinstatement. Two specific aims are proposed. First, we will determine if there are sex differences in discriminative social cue-induced reinstatement and if social cues potentiate the ability of contextual cues to reinstate drug seeking. Second, in these of behavioral experiments, c-Fos protein immunoreactive cells will be quantitated in various brain regions to determine if neural activation following social cues differs between males and females or if activation by social cues differs from contextual cues. If social cues prove to be a trigger for drug seeking, this would provide evidence that informs psychosocial treatments which emphasize skill-building to avoid deviant peers.

项目摘要 药物滥用从业人员面临的最困难的问题之一是持续的高复发率 治疗后。虽然有多个内部状态和外部提示可能会触发复发，但 常见因素是与吸毒的社会同伴重新建立联系。虽然最近有一些临床前工作 研究了社会影响在获取和维持毒品自我管理方面的作用，有 本质上，没有关于社会线索在恢复毒品寻求毒品中的作用的信息。总体假设 这个项目的是，自我管理的社交同龄人将成为诱导在受控的人中寻求毒品的提示 临床前实验室环境。与离散提示（光，音调）和上下文提示（触觉和视觉 提示，一天中的时间），这些研究将确定社交同伴是否也能够恢复被灭绝 响应毒品。此外，这些研究将提供有关潜在互动的明确信息 恢复社会和上下文提示的影响。提出了两个具体目标。首先，我们会的 确定歧视性社会提示引起的恢复和社会提示是否存在性别差异 增强上下文提示恢复吸毒的能力。第二，在行为实验中， C-FOS蛋白免疫反应性细胞将在各种大脑区域进行定量，以确定神经激活是否激活 跟随社会提示在男性和女性之间有所不同，或者通过社会提示激活与上下文不同 提示。如果社会提示被证明是寻求毒品的触发因素，这将提供证据表明 强调技能建设以避免出现偏差的同伴的社会心理治疗。