Social Cues and Drug Relapse

社会暗示和药物复发

• 批准号: 9245436
• 负责人: Michael T Bardo
• 金额: $ 21.31万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2019-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9245436
• 关键词: Beer; Behavioral; Brain; Brain Diseases; Brain region; Cells; Chronic; Cocaine; Cues; Discrimination; Drug abuse; Drug usage; Environment; Exposure to; Extinction (Psychology); FOS Protein; FOS gene; Female; Goals; Individual; Intervention; Laboratories; Light; Lighting; Measures; Modeling; Odors; Patient Self-Report; Pattern; Pharmaceutical Preparations; Pharmacotherapy; Play; Pre-Clinical Model; Predisposing Factor; Prevention strategy; Procedures; Process; Rattus; Relapse; Reporting; Role; Saline; Self Administration; Self-Administered; Sex Characteristics; Syringes; System; Tactile; Testing; Time; Training; Treatment Efficacy; Visual; Work; cocaine use; community setting; craving; deviant; disorder later incidence prevention; drug abuser; drug maintenance; drug relapse; experimental study; immunoreactivity; male; peer; pre-clinical; psychosocial; relating to nervous system; response; skills; social; treatment program

PROJECT SUMMARY One of the most difficult problems facing drug abuse practitioners is the continuing high rate of relapse following treatment. While there are multiple internal states and external cues that may trigger relapse, one common factor is to re-associate with drug-using social peers. Although some recent preclinical work has examined the role of social influence on acquisition and maintenance of drug self-administration, there is essentially no information about the role of social cues in reinstatement of drug seeking. The overall hypothesis of this project is that self-administering social peers will serve as a cue to induce drug seeking in a controlled preclinical laboratory setting. Separate from discrete cues (light, tone) and contextual cues (tactile and visual cues, time of day), these studies will determine if social peers also are able to reinstate extinguished responding for drug. In addition, these studies will provide definitive information about the potential interactive effects of social and contextual cues in reinstatement. Two specific aims are proposed. First, we will determine if there are sex differences in discriminative social cue-induced reinstatement and if social cues potentiate the ability of contextual cues to reinstate drug seeking. Second, in these of behavioral experiments, c-Fos protein immunoreactive cells will be quantitated in various brain regions to determine if neural activation following social cues differs between males and females or if activation by social cues differs from contextual cues. If social cues prove to be a trigger for drug seeking, this would provide evidence that informs psychosocial treatments which emphasize skill-building to avoid deviant peers.

项目概要 药物滥用从业者面临的最困难的问题之一是持续高的复发率 治疗后。虽然有多种内部状态和外部线索可能会引发复发，但其中一种 共同因素是与吸毒的社会同伴重新交往。尽管最近的一些临床前工作 研究了社会影响对获得和维持自我给药的作用，有 基本上没有关于社会线索在恢复吸毒过程中的作用的信息。总体假设 该项目的重点是，自我管理的社会同伴将作为一个线索，在受控的环境中诱导药物寻求 临床前实验室设置。与离散线索（灯光、音调）和上下文线索（触觉和视觉）分开 线索、一天中的时间），这些研究将确定社会同伴是否也能够恢复熄灭的状态 响应药物。此外，这些研究将提供有关潜在互动的明确信息 社会和情境线索对恢复的影响。提出了两个具体目标。首先，我们将 确定歧视性社会线索诱导的恢复是否存在性别差异，以及社会线索是否存在 增强情境线索恢复药物寻求的能力。其次，在这些行为实验中， 将对不同大脑区域的 c-Fos 蛋白免疫反应细胞进行定量，以确定神经激活是否 男性和女性遵循的社交线索不同，或者社交线索的激活是否与情境不同 提示。如果社会线索被证明是寻求毒品的触发因素，这将提供证据来告知 心理社会治疗强调技能培养，以避免同龄人出现异常行为。