Center for Humanized Mice

人源化小鼠中心

基本信息

批准号：
9512259
负责人：
Santhi Gorantla
金额：
$ 36.4万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9512259
关键词：
Age Animal Model Animal Testing Animals Anti-Retroviral Agents Antiviral Agents Brain CMP-N-acetylneuraminate monooxygenase Cells Cellular biology Clinical Clinical Research Communities Comorbidity Development Diagnostic Disease Drug Interactions Engineering Foundations Funding Goals HIV HIV-1 HIV-associated neurocognitive disorder HIV/HCV Hematopoietic stem cells Hepatitis Hepatitis B Hepatocyte Histocompatibility Human ITGAM gene ITGAX gene Immune Immune response Immune system Immunity Infection Investigation Knock-out Knockout Mice Liver Mainstreaming Malaria Measures Medical center Microglia Modeling Mononuclear Mouse Strains Mus Natural Immunity Nebraska Organ Patients Pattern Phagocytes Pharmaceutical Preparations Pharmacology and Toxicology Pharmacy (field)Phenotype Research Infrastructure Research Personnel Resources Role Safety Speed Spleen Testing Therapeutic Tissue Banks Tissues Toxicology Transgenic Mice Translations Transplantation Tuberculosis Universities Vaccines Virus Diseases Xenograft procedure adaptive immune response adaptive immunity base biomedical resource clinical efficacy co-infection design drug discovery drug metabolism environmental toxicology granulocyte human disease human tissue humanized mouse improved macrophage microbial monocyte mouse development mouse model novel therapeutics novel vaccines pathogen pre-clinical public health relevance reconstitution sex success therapeutic development tool translational study vaccine candidate vaccine development vaccine evaluation vaccine trial virology

项目摘要

DESCRIPTION (provided by applicant): This proposal seeks funds to establish a Center for Humanized Mice Development. This new facility at the University of Nebraska Medical Center (UNMC) will offer environmentally, genetically, and xenotransplantation- engineered mouse models for translational studies and drug discovery, which are the mainstream at UNMC. It is well known that often clinical studies are successful in animal models but fail at the human level. Also the focused use of micro-animals, mice in particular, makes applicability to humans problematic. In turn, we are developing a resource that will generate improved animal models to study human immunity, human-specific infections, vaccines, and human-specific drug interactions. The resources are expected to be efficiently utilized for speeding the translation of new therapeutics to patients. Our goals to improve existing strains of mice are as follows: modify mouse backgrounds for the studies of human-like adaptive immune responses to broader range of pathogens and evaluation of vaccine candidates, create strains of mice that are compatible with the function of human immune system based on human-like glycosilation patterns, modify mouse backgrounds for studies of human-like drug metabolism and drug interaction, study HIV-1-related co-infections, such as hepatitis, tuberculosis, and malaria, and lastly examine HIV-1-associated comorbidities, including end-organ diseases like HIV-1-associated neurocognitive disorders (HAND).

描述（由申请人提供）：该提案寻求资金建立人源化小鼠开发中心。内布拉斯加州大学医学中心（UNMC）的新设施将在环境，遗传和异种移植工程的小鼠模型上提供转化研究和药物发现，这是UNMC的主流。众所周知，临床研究通常在动物模型中成功，但在人类水平上失败。同样，小鼠的重点使用微动物，尤其是小鼠的适用性。反过来，我们正在开发一种资源，该资源将产生改进的动物模型，以研究人类免疫力，人类特异性感染，疫苗和人类特异性药物相互作用。预计资源将有效地用于加速翻译对患者的新疗法。 Our goals to improve existing strains of mice are as follows: modify mouse backgrounds for the studies of human-like adaptive immune responses to broader range of pathogens and evaluation of vaccine candidates, create strains of mice that are compatible with the function of human immune system based on human-like glycosilation patterns, modify mouse backgrounds for studies of human-like drug metabolism and drug interaction, study HIV-1-related共同感染，例如肝炎，结核病和疟疾，最后检查HIV-1相关的合并症，包括HIV-1相关神经认知疾病（Hand）等最终器官疾病。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18.

DOI：
10.1111/acer.13226
发表时间：
2016-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
0
作者：
Ganesan M;Poluektova LY;Tuma DJ;Kharbanda KK;Osna NA
通讯作者：
Osna NA

Liver as a target of human immunodeficiency virus infection.

DOI：
10.3748/wjg.v24.i42.4728
发表时间：
2018-11-14
期刊：
World journal of gastroenterology
影响因子：
4.3
作者：
Ganesan M;Poluektova LY;Kharbanda KK;Osna NA
通讯作者：
Osna NA

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice.

DOI：
10.1242/bio.029785
发表时间：
2018-02-13
期刊：
Biology open
影响因子：
2.4
作者：
Dagur RS;Wang W;Cheng Y;Makarov E;Ganesan M;Suemizu H;Gebhart CL;Gorantla S;Osna N;Poluektova LY
通讯作者：
Poluektova LY