Meta-Analysis of Male Sexual Orientation

男性性取向的荟萃分析

• 批准号: 9357379
• 负责人: Eden R. Martin
• 金额: $ 19.31万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9357379
• 关键词: Address; Affect; Alleles; Area; Attention; Basic Science; Behavior; Biocompatible Materials; Biological; Biology; Brain; Characteristics; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 8; Complex; DNA; Data; Databases; Detection; Development; Environmental Risk Factor; Etiology; European; Event; Family; Family Study; Funding; Future; Genetic; Genetic study; Goals; Heritability; Heterosexuality; Heterosexuals; Homosexuality; Homosexuals; Human; Individual; Journals; Knowledge; Learning; Letters; Life; Maps; Meta-Analysis; Mind; Minority; Molecular; Molecular Genetics; Nature; Phenotype; Publishing; Reporting; Research; Resources; Sample Size; Sampling; Science; Sex Behavior; Sex Chromosomes; Sex Orientation; Sexual Development; Sexuality; Siblings; Societies; Statistical Data Interpretation; Surface; Twin Studies; Variant; Woman; Work; brain behavior; database of Genotypes and Phenotypes; genetic linkage; genetic variant; genome wide association study; genome-wide; genome-wide analysis; genome-wide linkage; genotyping technology; interest; male; meetings; men; posters; public health relevance; sample collection; segregation; social; trait; willingness

 DESCRIPTION (provided by applicant): This project will provide the most comprehensive study to date on the genetics of male sexual orientation. The main justifications for basic research on the etiology and development of sexual orientation include that it carries much social importance and interest, and that such research will illuminate sexual characteristics of brain, mind and behavior, thus informing society about currently unknown biological aspects behind male sexual orientation. Male sexual orientation is known to be heritable, but is multifactorial in nature with multiple genetic and environmental factors contributing to its etiology. Genetic linkage studies have found strong evidence of specific genetic loci (pericentromeric chromosome 8 and chromosome Xq28). Genome-wide association studies (GWAS) for sexual orientation are only just beginning to surface. There is a great need to combine studies to elucidate the genetics of this important biological trait. In this proposal, we plan to conduct meta-analysis of several genome-wide linkage studies (GWLS) and GWAS to maximize the ability to identify genetic targets for future study. Our specific aims are as follows 1. Determine the most promising linkage regions by meta-analyzing GWLS for male sexual orientation: our own GWLS of 409 ASPs, plus other collaborative GWLS of 155 ASPs, totaling 564 ASPs (representing 91% of the field's ASPs). 2. Conduct a meta-analysis of available GWAS for male sexual orientation using our European ancestry (EA) GWAS of 701 homosexual and 1,214 heterosexual men, plus other collaborative GWAS, en masse currently totaling 5,752 homosexual and 39,286 heterosexual men, and growing. Our results will be instrumental to a better understanding of the genetic contributions to male sexual orientation and also enable future approaches aimed at locating genetic variants contributing to trait variation, especially re sequencing. Finding linkage, association, or eventually contributory genetic variants will open a gateway to additional research that will inform the study of genetic and environmental mechanisms and developmental events influencing sexual orientation.

 描述（由适用提供）：该项目将提供有关男性性取向遗传学的最全面的研究。关于性取向的病因和发展基础研究的主要理由包括它具有许多社会意义和兴趣，并且这种研究将阐明大脑，思想和行为的性特征，从而向社会告知男性性取向背后未知的生物学方面。已知男性性取向是可遗传的，但本质上是多因素的，具有多种遗传和环境因素有助于其病因。遗传连锁研究发现了特定遗传位置的有力证据（果粒染色体8和XQ28染色体）。全基因组关联研究（GWAS）的性取向才刚刚开始浮出水面。非常需要结合研究以阐明这种重要的生物学特征的遗传学。在此提案中，我们计划对几项全基因组联系研究（GWLS）和GWAS进行荟萃分析，以最大程度地提高鉴定遗传靶标的未来研究的能力。我们的具体目的如下1。通过荟萃分析的男性性取向确定最有希望的联系区域：我们自己的409个ASP的GWLS，以及其他155个ASP的其他协作GWLS，总计564 ASP，总计564 ASP（代表91％的ASP）。 2.使用我们的欧洲血统（EA）GWAS 701同性恋和1,214个异性恋男性以及其他协作GWAS进行荟萃分析，以实施男性性取向，以实施5,752个同性恋和39,286个异性恋男人和成长。我们的结果将有助于更好地理解对男性性取向的遗传贡献，并使未来的方法旨在定位有助于特质变异的遗传变异，尤其是RE 测序。寻找联系，关联或有时导致遗传变异的贡献将为其他研究开辟一门门户，这将为您研究影响性取向的遗传和环境机制和发展事件的研究。