Specialized Program Of Research Excellence (SPORE) in Leukemia

白血病专业卓越研究计划 (SPORE)

• 批准号: 9307740
• 负责人: Daniel C Link
• 金额: $ 230万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-03 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307740
• 关键词: Acute Lymphocytic Leukemia; Acute Myelocytic Leukemia; Agreement; Attenuated; Basic Science; Biological Assay; Biometry; Blast Cell; Bone Marrow; CSF3 gene; CXCR4 gene; Cells; Clinical; Collaborations; DNA Methylation; Decitabine; Development; Disabled Persons; Dysmyelopoietic Syndromes; Epigenetic Process; Female; Gene Expression Profile; Gene Mutation; Genome; Genomics; Goals; Hematopoiesis; Immunology; Institution; Iowa; Lymphoma; Lymphopoiesis; Marrow; Mentors; Methods; Minority; Molecular; Mutation; Ohio; Patients; Program Development; RNA Splicing; Recruitment Activity; Regulatory T-Lymphocyte; Research; Research Infrastructure; Research Personnel; Resources; Specialized Program of Research Excellence; Spliced Genes; Stem cells; Syndrome; Technology; Testing; Training; Translational Research; Universities; Washington; cancer genome; cancer genomics; career development; chemotherapy; graft vs host disease; innovation; leukemia; leukemia treatment; next generation sequencing; novel; novel marker; novel strategies; predicting response; programs; public health relevance; response; translational cancer research

DESCRIPTION (provided by applicant): The Washington University SPORE in Leukemia is a highly dynamic translational cancer research program that focuses specifically on leukemias and myelodysplastic syndromes (MDS). We have assembled an outstanding group of investigators with complementary expertise in basic and clinical leukemia research. In this SPORE, we leverage expertise in cancer genomics, immunology, and hematopoiesis to develop innovative translational research in leukemia. Our long term goal is to develop novel biomarkers and treatments for leukemias and MDS and to recruit and promote innovative translational leukemia research. To achieve these goals, the following specific aims are proposed. Aim 1. To exploit recent advances in cancer genomics to develop novel biomarkers and treatments for leukemias and MDS. Washington University has been at the forefront of genomic studies in AML and MDS. Through sequencing of primary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) genomes, we identified several novel recurring mutations of genes involved in DNA methylation (DNMT3A and IDH1) and RNA splicing (U2AF1). This basic research has led to the development of the following two translational SPORE projects. Project 1. Molecular determinants of decitabine responsiveness Project 3. Development of RNA splicing modulators for myelodysplastic syndromes and AML. Aim 2. To leverage local expertise in immunology and hematopoiesis to develop novel treatments for leukemias and myelodvsplastic syndromes. Institutional expertise in basic immunology and hematopoiesis research has led to the development of two innovative translational projects in leukemia. Project 2. Targeting the bone marrow microenvironment in acute lymphocytic leukemia. Project 4. Epigenetic modulation of graft versus host disease and graft versus leukemia. Aim 3. To enhance the infrastructure that supports translational leukemia research. This SPORE will support the following Shared Research Resources: 1) Core A. Biospecimen Processing; 2) Core B. Biostatistics; and 3) Core C. Administration. Aim 4. To recruit and train new investigators in translational research. Aim 5. To facilitate inter-SPORE collaboration.

描述（由申请人提供）：华盛顿大学白血病孢子是一项高度动态的转化癌研究计划，专门针对白血病和骨髓增生综合症（MDS）。我们组建了一群杰出的研究人员，具有基础和临床白血病研究方面的补充专业知识。在这种孢子中，我们利用癌症基因组学，免疫学和造血的专业知识来发展白血病的创新转化研究。我们的长期目标是为白血病和MD开发新颖的生物标志物和治疗方法，并招募和促进创新的翻译白血病研究。为了实现这些目标，提出了以下特定目标。 目的1。利用癌症基因组学的最新进展来开发白血病和MD的新生物标志物和治疗方法。华盛顿大学一直处于AML和MDS基因组研究的最前沿。通过对原发性急性髓样白血病（AML）和骨髓增生综合征（MDS）基因组进行测序，我们确定了参与DNA甲基化（DNMT3A和IDH1）和RNA旋转（U2AF1）的几种新型基因重复突变（U2AF1）。这项基础研究导致了以下两个翻译孢子项目的发展。 项目1。解替滨反应性的分子决定因素 项目3。用于骨髓增生综合征和AML的RNA剪接调节剂的开发。 目的2。利用当地的免疫学和造血专业知识来开发白血病和骨髓增生综合征的新型治疗方法。基本免疫学和造血研究方面的机构专业知识导致了白血病的两个创新转化项目的发展。 项目2。针对急性淋巴细胞性白血病的骨髓微环境。 项目4。移植物与宿主疾病与嫁接与白血病的表观遗传调节。 目标3。增强支持翻译白血病研究的基础设施。该孢子将支持以下共享的研究资源：1）核心A. Biospececimen Processing； 2）核心 B.生物统计学； 3）核心C.管理。 目标4。招募和培训新调查人员的转化研究。 目的5。促进跨间的合作。