Nervous System Development and Injury

神经系统发育和损伤

基本信息

批准号：
9386458
负责人：
DAVID M. HOLTZMAN
金额：
$ 0.83万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9386458
关键词：
Injury nervous system development

项目摘要

DESCRIPTION (provided by applicant): The present application seeks continued funding for a training program at Washington University Medical School that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 29 years. The theme of the research carried out by the trainees and faculty of this grant is translational research in nervous system injury and degeneration. The primary applicant pool for the four slots requested are MD or MD/PhD residents in adult neurology, pediatric neurology, and neurosurgery at this institution. A limited number of Ph.D. candidates carrying out research consistent with the theme in the laboratories of the faculty members will also be considered, as will residents from other neuroscience-related clinical departments or residents from other institutions that seek training with our faculty. The faculty of 45 is composed of well-funded members of several clinical and basic science departments, most of whom have extensive experience in training young scientists and physician scientists. It is expected that trainees supported by this grant will carr out laboratory-based and/or clinically-based translational research for a minimum of two years as this is the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinician scientists needed to advance our understanding of the pathogenesis and treatment of these neurological disorders. In addition to the mentored research projects, trainees will participate, depending upon interests and experience, in individually designed didactic (courses, workshops, journal clubs) programs to develop needed background, specialized technical skills, and communication skills in preparation for an independent research career. All trainees will also receive training in the ethical conduct of research appropriate for whether they are primary focused on clinical vs. laboratory-based research. Procedures are described to select, evaluate, and counsel trainees. We have enjoyed reasonable success in identifying excellent minority participants in the program and efforts to further strengthen this aspect of our program are described. This program has, and will continue to, build upon the long tradition of excellent basic and clinical neuroscience at Washington University toward the objective of training the next generation of clinician scientists dedicated to understanding and treating disorders of the nervous system.

描述（由申请人提供）：本申请寻求继续为华盛顿大学医学院的培训计划提供资金，该计划在过去29年中由神经病学和神经手术部门共同管理。这项赠款的学员和教师进行的研究主题是紧张的转化研究系统损伤和变性。所需的四个插槽的主要申请人池是该机构的成人神经病学，儿科神经病学和神经外科手术的MD或MD/PHD居民。有限的博士学位也将考虑与其他与神经科学相关的临床部门的居民或其他寻求与我们教职员工培训的机构的居民一样，也将考虑与教师实验室中的主题相一致的研究的候选人。 45名教职员工由几个临床和基础科学部门的资助良好的成员组成，其中大多数在培训年轻科学家和医师科学家方面都有丰富的经验。预计这笔赠款支持的受训者将至少提供基于实验室和/或基于临床的转化研究，因为这是开发经过科学训练的神经系统或神经外科临床临床科学家所需的最低期限，以促进我们对这些神经疾病的病原体的理解和治疗。除了有指导的研究项目外，学员还将根据兴趣和经验参加，以个人设计的教学（课程，讲习班，期刊俱乐部）计划，以发展所需的背景，专业的技术技能和沟通技巧，以准备独立研究职业。所有学员还将接受有关研究的道德行为培训，适合于他们是否主要专注于临床和基于实验室的研究。描述了选择，评估和律师培训人员的程序。我们在确定该计划的少数族裔参与者方面取得了合理的成功，并介绍了进一步加强我们计划的这一方面的努力。该计划的发展基于华盛顿大学出色的基本和临床神经科学的悠久传统，目的是培训下一代临床医生，致力于理解和治疗神经系统的疾病。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Upregulation of NMDARI mRNA induced by MK-801 is associated with massive death of axotomized motor neurones in adult rats.

MK-801 诱导的 NMDARI mRNA 上调与成年大鼠轴突运动神经元的大量死亡有关。

DOI：
10.1006/nbdi.1994.0015
发表时间：
1994
期刊：
Neurobiology of disease
影响因子：
6.1
作者：
Sanner,C;Elliott,JL;Snider,WD
通讯作者：
Snider,WD

Laser ablation as treatment strategy for medically refractory dominant insular epilepsy: therapeutic and functional considerations.

DOI：
10.1159/000366001
发表时间：
2014
期刊：
Stereotactic and functional neurosurgery
影响因子：
1.7
作者：
Hawasli AH;Bandt SK;Hogan RE;Werner N;Leuthardt EC
通讯作者：
Leuthardt EC

Intraoperative magnetic resonance imaging to reduce the rate of early reoperation for lesion resection in pediatric neurosurgery.

术中磁共振成像可降低小儿神经外科病灶切除的早期再次手术率。

DOI：
10.3171/2011.12.peds11227
发表时间：
2012
期刊：
Journal of neurosurgery. Pediatrics
影响因子：
0
作者：
Shah,ManishN;Leonard,JeffreyR;Inder,Gabrielle;Gao,Feng;Geske,Michael;Haydon,DevonH;Omodon,MelvinE;Evans,John;Morales,Diego;Dacey,RalphG;Smyth,MatthewD;Chicoine,MichaelR;Limbrick,DavidD
通讯作者：
Limbrick,DavidD

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury.

神经生长因子在成人背根神经节神经元中的作用及其对损伤的反应。