Mentoring researchers on drug abuse and HIV

指导药物滥用和艾滋病毒研究人员

基本信息

批准号：
9240580
负责人：
Chinazo Cunningham
金额：
$ 4.85万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9240580
关键词：
Abstinence Address Adherence Agonist Area Award Behavior Blood Tests Buprenorphine CD4 Lymphocyte Count Caring Clinical Trials Cocaine Color Communities Complex Control Groups Data Databases Drug abuse Drug usage Drug user Enrollment Ensure Epidemic Feedback Foundations Funding Goals HIV HIV Infections HIV risk Health Health Services Accessibility Healthcare Highly Active Antiretroviral Therapy Improve Access Incentives Individual International Intervention Leadership Medical Records Medical center Medicine Mentors Mentorship Methadone Methods Motivation Neurocognitive Opiate Addiction Opiates Opioid Outcome Oxycodone Participant Patients Performance Pharmaceutical Preparations Population Positioning Attribute Public Health Questionnaires Randomized Randomized Controlled Trials Reading Research Research Infrastructure Research Methodology Research Personnel Research Project Grants Research Support Risk Risk Behaviors Smoker Smoking Cessation Intervention Standardization Structure Testing Toxicology Treatment outcome United States National Institutes of Health Urine Viral Load result Woman base career cocaine use comparative effectiveness contingency management effectiveness research efficacy testing ethnic minority population health care availability health disparity improved improved outcome novel strategies opioid use patient oriented research pill prescription opioid primary outcome programs public health relevance racial and ethnic secondary outcome skills success symposium therapy adherence trial design voucher

项目摘要

DESCRIPTION (provided by applicant): Drug users with and at-risk for HIV continue to have poor access to health care and poor treatment outcomes. In addition, opioid addiction involving prescription opioids has skyrocketed. In this proposal for a mid-career investigator award, Dr. Chinazo Cunningham proposes to address the opioid epidemic and its intersection with HIV infection by: 1) becoming an internationally recognized leader in the field of drug abuse and HIV, expanding her research to include advanced research methods (comparative effectiveness research [CER] methods and complex clinical trials methods); 2) developing a standardized and structured mentorship approach to mentor junior investigators to conduct patient-oriented research related to drug abuse and/or HIV infection; and 3) becoming an effective leader in academic medicine, ensuring that the institutional infrastructure facilitates junior investigators obtaining skills necessary to become independent investigators. To achieve these goals, Dr. Cunningham will participate in courses and national conferences, have directed readings, and regularly meet with national leaders in related fields. Dr. Cunningham will particularly focus on mentoring women and racial/ethnic minorities-two groups who are under-represented in senior positions in academic medicine and NIH-funded research. Dr. Cunningham will utilize her existing research program as a foundation for which she will provide mentoring and expand her research skills to include CER and complex clinical trials methods. The aims of her research are to: 1) test the efficacy of a 16-week abstinence-reinforcing contingency management intervention on HIV viral load suppression among opioid-dependent HIV-infected individuals, using a randomized controlled trial design; and 2) examine mechanisms of achieving viral load suppression with the abstinence-reinforcing contingency management intervention. Dr. Cunningham's future research will include the establishment of a comprehensive "live" database of all opioid users within a large urban medical center. This database will be used to examine health outcomes associated with types of opioid use and to develop and test interventions focused on opioid use. Dr. Cunningham's long-term career objective is to improve access to care and health outcomes among drug-abusing populations with or at-risk for HIV infection by developing interventions that can reduce their disparities in health care and health.

描述（由申请人提供）：艾滋病毒和艾滋病毒高危的吸毒者继续无法获得医疗保健和治疗结果不佳。此外，涉及处方阿片类药物的阿片类药物成瘾激增。在这项中期研究员奖的提案中，Chinazo Cunningham博士提议通过以下方面解决阿片类药物的流行及其与HIV感染的相交：1）成为药物滥用和HIV领域的国际认可的领导者，将其研究扩大到包括先进的研究方法（包括高级研究方法）（比较有效研究方法和复杂的临床试验方法[CER]方法[CER]方法[CER [CER]方法[CER]方法[CER [CER]方法）； 2）开发一种标准化和结构化的指导方法，以指导初级研究人员进行与药物滥用和/或HIV感染有关的患者研究； 3）成为学术医学的有效领导者，确保机构基础设施有助于初级研究人员获得成为独立研究人员所必需的技能。为了实现这些目标，坎宁安博士将参加课程和民族会议，指导阅读，并定期与相关领域的国家领导人见面。坎宁安博士将特别专注于指导妇女和种族/族裔少数民族两个群体，这些团体在学术医学和NIH资助的研究领域的高级职位不足。坎宁安博士将利用她现有的研究计划作为基础，她将为其提供指导并扩大研究技能，包括CER和复杂的临床试验方法。她的研究的目的是：1）使用随机对照试验设计，测试对阿片类药物依赖性HIV感染的个体对HIV病毒负荷抑制艾滋病毒载荷抑制的16周戒酒应有性管理干预的功效； 2）检查使用禁欲的应急管理干预措施来实现病毒载荷抑制的机制。坎宁安博士的未来研究将包括建立大型城市医学中心中所有阿片类药物用户的全面“实时”数据库。该数据库将用于检查与阿片类药物使用类型相关的健康结果，并开发和测试针对阿片类药物使用的干预措施。坎宁安博士的长期职业目标是通过开发可以减少其医疗保健和健康方面差异的干预措施来改善患有艾滋病毒感染或处于艾滋病毒感染的毒品滥用或处于危险中的医疗保健和健康成果的机会。