One Health; Epidemiology of natural and deliberate contaminants (infectious and toxicities) in animals and animal food

一个健康；

• 批准号: 9475396
• 负责人: SUSAN SANCHEZ
• 金额: $ 3.15万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9475396
• 关键词: Health; Epidemiology; natural; deliberate; contaminants

Project Summary In the United States food destined for pet consumption is normally safe for both the pets and the people who handle the food. The need for the cheap production of these food commodities and the fact that we live in a more global society has changed the sources of the components of pet food. As a result, there have been several occurrences of zoonotic infectious disease transmission and toxicities. Salmonella present in dog treats and pet food has sickened people that handle them or were in contact with their pets while shedding such bacteria. These outbreaks were due to contamination during processing, probably preventable, but definitely not malicious. In some other instances, such as in the case of melamine toxicosis, the introduction was deliberate in an effort to profit through the fraudulent substitution of an adulterant. The University of Georgia, through its “One Health” initiative, is committed to promoting, training, and conducting research in all areas of animal, human and environmental health. The College of Veterinary Medicine and the State Veterinary Diagnostic Laboratory have a duty to the state and to its constituents to not only perform diagnosis but also to monitor trends and report unusual disease presentations or patterns. Our laboratory takes this responsibility very seriously, and over the years our faculty members have published articles with such findings. Furthermore, we were the first laboratory to diagnose melamine toxicosis in dogs due to contaminated components present in canned pet food. We were not only able to describe the outbreak in the US, but also by working with our network of collaborators, link it to an outbreak in Korea. Moreover, the PI has worked extensively in the study of the chicken gut micro-biome, including the distribution of antimicrobial resistance, and the epidemiology of Salmonella in wildlife and the environment. Our laboratory has expertise in the areas of pathology, bacteriology, parasitology, virology, serology, and molecular biology, including high throughput platform testing. Our faculty and staff are highly qualified and are devoted to animal and public health. Our commitment is evident in our participation in many programs at the state and national levels. We are one of the core laboratories of the National Animal Health laboratory Network (NAHLN) and participate in all NAHLN surveillance testing. In addition, we are have participated in another cooperative agreement with the FDA assessing the presence of Salmonella in turkey-based pet treats as well as engaging in an epidemiological study looking at the prevalence of Salmonella in dog and cat feces (1U8FD004318-01) and the potential risk factors for Salmonella carriage. Furthermore, we are currently on the last year of our first competitive renewal of the 1U18FD004623-01-infrastructure grant, for which here by we are seeking renewal. We have been very responsive to all the requirements of this grant to date. Therefore, Athens Veterinary Diagnostic Laboratory and the PI in this application are uniquely positioned to assist the FDA in meeting the important goals of the project described in this competitive renewal.

项目摘要 在美国，注定要供宠物食用的食物通常对宠物和宠物都是安全的 处理食物。需要这些食品的廉价生产以及我们生活在 越来越多的全球社会改变了宠物食品组成部分的来源。结果，有 人畜共动性传染病的传播和毒性发生了几种。狗中存在的沙门氏菌 宝藏和宠物食品使处理它们的人有恶心或与宠物接触的人 这样的细菌。这些爆发是由于处理过程中的污染，可能是可预防的，但 绝对不是恶意的。在其他情况下，例如在三聚氰胺有毒中毒的情况下，引言 是为了通过欺诈性替代通奸者而进行旨在获取的努力。 佐治亚大学通过其“一个健康”倡议致力于促进，培训和 在动物，人类和环境健康的所有领域进行研究。兽医学院 医学和州兽医诊断实验室对国家有责任 仅执行诊断，还可以监测趋势并报告异常的疾病表现或模式。我们的 实验室非常重视这一责任，多年来，我们的教职员工发表了 具有这样的发现的文章。此外，我们是第一个诊断狗的三聚氰胺毒性的实验室 由于罐头食品中存在的污染成分。我们不仅能够描述爆发 在美国，而且还通过与我们的合作者网络合作，将其链接到韩国的爆发。而且， PI在研究鸡肉肠道微生物中广泛工作，包括分布 抗菌素耐药性以及野生动植物和环境中沙门氏菌的流行病学。 我们的实验室在病理，细菌，寄生虫学，病毒学，血清学和 分子生物学，包括高吞吐量平台测试。我们的教职员工都有很高的资格，并且 致力于动物和公共卫生。我们的承诺是我们参与许多计划的证据 州和国家一级。我们是国家动物卫生实验室的核心实验室之一 网络（NAHLN）并参加所有NAHLN监视测试。此外，我们参加了 与FDA的另一个合作协议评估了基于土耳其的宠物零食中沙门氏菌的存在 以及从事一项流行病学研究，以研究狗和猫粪便中沙门氏菌的流行 （1U8FD004318-01）和沙门氏菌载体的潜在危险因素。此外，我们目前正在 我们第一次竞争续约1U18FD004623-01-INFRASTRUCTURE GRANT的去年，我们在这里为此 正在寻求续约。迄今为止，我们对这笔赠款的所有要求都非常敏感。所以， 雅典兽医诊断实验室和此应用中的PI独特地定位于 协助FDA实现此竞争更新中描述的项目的重要目标。