CREP

基本信息

批准号：
9355130
负责人：
Carla Edge Oldham
金额：
$ 4.84万
依托单位：
NORTH CAROLINA CENTRAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9355130
关键词：
Active Learning Address African American Area Awareness Benefits and Risks Biological Cancer Model Clinical Clinical Research Clinical Trials Collection Communities Community Outreach Comprehensive Cancer Center Data Analyses Development Diverse Workforce Doctor of Philosophy Drug Delivery Systems Drug Formulations Education and Outreach Emerging Technologies Ensure Evaluation Event Exposure to Faculty Feedback Future Genetic Genomics Goals Grant Historically Black Colleges and Universities Human Institutes Institution International Knowledge Laboratories Laboratory Research Learning Malignant Neoplasms Mentors Mentorship Minority Minority Participation Molecular North Carolina Operations Research Participant Pathway interactions Patients Phase Postdoctoral Fellow Process Professional Competence Proteomics Publications Readiness Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Training Resources Role Rotation Students System Tissue Banks Training Training Programs Training Technics Translational Research Translational Research Working Group Underrepresented Minority United States National Institutes of Health Universities Writing anticancer research base bench to bedside biomarker identification cancer clinical trial cancer health disparity career career development career preparation cohort collaborative environment curriculum development education research epigenomics graduate student health disparity health equity innovation laboratory experience matriculation member minority scientist minority trainee multimodality novel novel therapeutics operation outreach peer coaching pre-clinical programs research study resilience sample collection skills success therapeutic target training opportunity translational cancer research translational research program

项目摘要

The North Carolina Central University (NCCU) – Duke Cancer Disparities Translational Research Partnership (NCCU-DUKE CDTRP) is focused on developing infrastructure for research and training in translational cancer research on molecular pathways contributing to the increased lethality of specific cancers in African Americans. The Program is built on long- standing relationships between these two Durham-based Institutions, less than four miles apart. NCCU is a minority-serving historically black university (HBCU), affiliated with the 17-member University of North Carolina system, and the Duke Cancer Institute (DCI) is an NCI-designated Comprehensive Cancer Center. The partnership will specifically focus on research and training areas described by the NIH Translational Research Working Group including genomics, epigenomics, proteomics and other emerging technologies around biomarkers, identification of novel preventative and therapeutic targets, and with the NCCU faculty bringing a unique focus from an HBCU on the development of new drugs and innovative drug formulation and delivery mechanism. The partnership will also include research and training around biospecimen collection and development of primary human cancer models for elucidation of biological and genetic factors associated with cancer health disparities, as well as clinical research operations and minority accrual to clinical and specimen collection trials. The partnership will develop around accelerated planning and priority-setting stages, particularly focused on development of a fully integrated, bi-directional, mutually beneficial Cancer Research Education Program (CREP) that rigorously addresses career development across doctoral graduate students, postdoctoral fellows, and early stage investigators. Multimodal training will be implemented and will include extensive laboratory research, mentoring, grant writing resources, cancer forums and colloquia, and exposure to clinical research operations and accrual. The objectives of this program are to 1. Provide comprehensive research training opportunities for minority PhD students and postdoctoral fellows in translational and pre-clinical/clinical cancer disparities research; 2. Adequately prepare minority scientists to enter into a diverse workforce for better matriculation into careers in translational cancer research and; 3. Provide trainees with a better understanding of translational/clinical research operations, processes, and patient accrual, with emphasis on minority accrual and patient navigation and community outreach. An extensive evaluation plan has been devised and metrics will be collected to provide crucial feedback to further develop more sustainable comprehensive efforts that significantly impact cancer disparities.

北卡罗来纳中央大学 (NCCU) – 杜克癌症差异转化研究合作伙伴关系（NCCU-DUKE CDTRP）专注于开发基础设施转化癌症研究的分子途径研究和培训有助于该计划建立在长期的基础上。这两个位于达勒姆的机构之间存在长期关系，相距不到四英里。 NCCU 是一所服务于少数族裔的历史悠久的黑人大学 (HBCU)，隶属于由 17 名成员组成的北卡罗来纳大学系统和杜克癌症研究所 (DCI) 是 NCI 指定的该合作伙伴关系将特别侧重于研究和培训。 NIH 转化研究工作组描述的领域包括基因组学、表观基因组学、蛋白质组学和其他围绕生物标志物的新兴技术、新颖的预防和治疗目标，NCCU 教师带来独特的关注点来自 HBCU 的新药开发以及创新药物配方和输送该伙伴关系还将包括围绕生物样本的研究和培训。收集和开发主要人类癌症模型，以阐明生物学和与癌症健康差异相关的遗传因素以及临床研究操作该伙伴关系将发展到临床和标本采集试验中。围绕加速规划和优先事项设定阶段，特别注重发展完全整合、双向、互利的癌症研究教育计划（CREP）严格解决博士研究生的职业发展问题，将实施博士后研究员和早期研究人员的多模式培训。将包括广泛的实验室研究、指导、资助写作资源、癌症论坛和座谈会，以及接触临床研究操作和应计目的。计划的目的是 1. 为少数族裔博士提供全面的研究培训机会转化和临床前/临床癌症差异方面的学生和博士后研究员 2. 为少数族裔科学家进入多元化的劳动力队伍做好充分准备进入转化癌症研究领域；3. 为学员提供更好的机会了解转化/临床研究操作、流程和患者应计情况，强调少数群体应计、患者导航和社区外展。已制定评估计划并收集指标，以便为以下人员提供重要反馈：进一步开展对癌症有重大影响的更可持续的综合努力差异。