Chronic Pancreatitis, Diabetes and Pancreatic Cancer: A Prospective Approach

慢性胰腺炎、糖尿病和胰腺癌：前瞻性方法

• 批准号: 9352337
• 负责人: Stephen K. Van Den Eeden
• 金额: $ 39.97万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352337
• 关键词: Abdominal Pain; Alcohol consumption; Algorithms; Area; Back Pain; California; Chronic; Clinical; Clinical Cancer Center; Clinical Research; Collaborations; Computerized Medical Record; Data; Data Coordinating Center; Data Quality; Diabetes Mellitus; Diagnosis; Disease; Endocrine; Etiology; Exocrine pancreatic insufficiency; Family; Family history of; Functional disorder; Genetic Predisposition to Disease; Genetic study; Health; Individual; Inflammation; Inflammatory; Inherited; Interview; Knowledge; Lead; Left; Lesion; Link; Malignant neoplasm of pancreas; Metabolic; Mutation; Nature; Outcome; Pain; Pancreas; Pancreatic Diseases; Pancreatitis; Pathologic; Patients; Peptide Hydrolases; Pilot Projects; Prediabetes syndrome; Prevention strategy; Process; Protocols documentation; Quality of life; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Resources; Risk Estimate; Sampling; Symptoms; Techniques; Testing; Tissues; Trauma; Work; biomarker development; chronic pancreatitis; cohort; data management; design; diabetes risk; epidemiology study; exome sequencing; follow-up; high risk; innovation; kindred; novel; outcome forecast; predictive modeling; programs; prospective; public health relevance; response; treatment strategy

 DESCRIPTION (provided by applicant): This application, in response to RFA-DK-14-007, seeks to advance the opportunities to study how chronic pancreatitis, pre-diabetes, diabetes and pancreatic cancer are related to each other. We seek to contribute to the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CSCPDPC) by bringing expertise, unique data and innovative proposed studies together to be part of this collaborative effort. We propose to develop the infrastructure to work with the CSCPDPC, conduct analyses directed at estimating the risk of type 3c diabetes mellitus (T3cDM) and/or pancreatic cancer associated with having chronic pancreatitis, develop two algorithms to identify patients with chronic pancreatitis at high risk of T3cDM and/or pancreatic cancer from electronic medical records, use the algorithms to identify, recruit and follow an inception cohort of 600 high risk individuals and to conduct a pilot genetic study of chronic pancreatitis. We believe our proposed research program conducted in collaboration with the other Clinical Centers and the Coordination and Data Management Center (CDMC) will advance our basic knowledge and lead to better prevention and treatment strategies.

 描述（由应用程序提供）：该应用程序响应RFA-DK-14-007，试图促进研究慢性胰腺炎，糖尿病前，糖尿病和胰腺癌之间如何相互关系的机会。我们试图通过将专业知识，独特的数据和创新拟议的研究融合在一起，以研究慢性胰腺炎，糖尿病和胰腺癌（CSCPDPC）的研究联盟。我们建议开发与CSCPDPC合作的基础架构，进行旨在估算3C糖尿病型糖尿病（T3CDM）的风险和/或胰腺癌的进行分析，以及与患有慢性胰腺炎相关的胰腺癌，从而开发出两种算法，以鉴定出在TRO​​CTIS癌症中鉴定出慢性胰腺炎的患者，从而在TRONIC PACCREATIS中使用TH3CDM和/或/或PACC的高风险。算法识别，招募和遵循600个高风险个体的成立队列，并进行慢性胰腺炎的初步遗传研究。我们相信，我们建议与其他临床中心合作进行的拟议研究计划，协调和数据管理中心（CDMC）将提高我们的基本知识，并带来更好的预防和治疗策略。