Schizophrenia: A Neuropsychiatric Perspective

精神分裂症：神经精神病学的视角

• 批准号: 9392422
• 负责人: Raquel E Gur
• 金额: $ 0.39万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-21 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392422
• 关键词: Schizophrenia; neuropsychiatry

DESCRIPTION (provided by applicant): Schizophrenia: A Neuropsychiatric Perspective is a training grant aiming to provide basic and clinical neuroscientists with the skills and experiences necessary to launch an interdisciplinary research career that can contribute to understanding the neurobiology of schizophrenia spectrum disorders. This competing renewal application capitalizes on the depth of resources, facilities and faculty dedicated to research and training in translational neuroscience at the University of Pennsylvania. The program forges cross-fertilization of clinical neuroscientists, with expertise in assessment and treatment of psychosis spectrum disorders, and basic neuroscientists, with new methodologies to probe neural mechanisms pertinent to psychosis. Training will be provided in four Units, reflecting concentrations of investigators and laboratories and state of the field: (1) Cognition and Affective Neuroscience~ (2) Neurogenetics~ (3) Cellular and Molecular Neuroscience~ (4) Clinical and Developmental Neuroscience. While each trainee will work primarily within a Unit, with a mentor supervising the research training, there will be common courses and workshops across Units. The didactic experiences will be coordinated by faculty to assure training in biostatistics and methodology, ethical conduct of research and a solid grounding in neuroscience. The 5-year post-doctoral program will have five trainees with M.D., M.D./Ph.D. and Ph.D. degrees, each trained for a period of 2-years. The program capitalizes on extensive experience of the participating laboratories, which have joint Center grants, RO1s, training programs, seminars, and enjoy a productive collaboration in all academic activities. The training program dovetails with the academic agenda of the Schizophrenia Research Center, where faculty interact by working collaboratively in research teams in ways that can serve as role models for trainees. We hope that our efforts will continue to help advance the careers of high quality clinical and basic neuroscientists who can move the field ahead collaboratively. Through active participation in research, combined with didactic course work, trainees learn to conduct research bridging clinical with basic neurosciences relevant to understanding the neurobiology of schizophrenia and other psychosis spectrum disorders. The Training Committee, which includes the scientific leaders of the Training Units, assists the Program Director in coordinating recruitment and admissions, assuring appropriate matching of Fellows to mentors and research laboratories, and monitoring quality and progress of training. Research projects of trainees span the scope of the participating laboratories with a focus on neurobiology of psychosis. Notably, the proposed program is the only one at Penn emphasizing the training of clinical and basic neuroscientists in the study of complex behavior and psychosis. It contributes the "critical mass," creating a stimulating and exciting research environment for trainees and for us.

描述（由申请人提供）：精神分裂症：神经精神科的观点是培训补助金，旨在为基本和临床神经科学家提供技能和经验 启动跨学科研究职业所必需的，该研究可以有助于理解精神分裂症谱系障碍的神经生物学。这种竞争性更新应用程序将利用专门用于研究和培训的资源，设施和教职员工的深度 宾夕法尼亚大学的翻译神经科学。该计划对临床神经科学家的交叉施加，具有评估和治疗精神病谱系障碍和基本神经科学家的专业知识，并具有探测与精神病有关的神经机制的新方法。培训将以四个单位提供，反映了研究人员和实验室以及该领域的状态：（1）认知和情感神经科学〜（2）神经遗传学〜（3）细胞和分子神经科学〜（4）临床和发育神经科学。虽然每个学员将主要在一个单位内工作，但在导师监督研究培训的情况下，将有跨单位的通用课程和讲习班。教师将协调教学经验，以确保在生物统计学和方法论，研究的道德行为以及神经科学领域的扎实基础上进行培训。 5年的博士后计划将拥有五名学员，医学博士，M.D./PH.D。和博士学位，每个学位都经过2年的培训。该计划利用了参与实验室的丰富经验，这些实验室拥有联合中心赠款，RO1，培训计划，研讨会，并在所有学术活动中享有富有成效的合作。该培训计划与精神分裂症研究中心的学术议程相吻合，在该中心的学术议程中，教师通过在研究团队中进行合作的方式进行互动，以可以作为受训者的榜样。我们希望我们的努力将继续帮助促进高质量的临床和基本神经科学家的职业，他们可以协作将该领域提前提高。通过积极参与研究，结合教学课程的工作，学员学习了与了解精神分裂症和其他精神病谱系障碍的神经生物学相关的基本神经科学的临床研究。 培训委员会包括培训单位的科学领袖，协助计划主任协调 招募和录取，确保将同伴与导师和研究实验室相匹配，并监视质量和培训进展。学员的研究项目涵盖了参与实验室的范围，重点是精神病神经生物学。值得注意的是，该计划是宾夕法尼亚州唯一强调临床和基本神经科学家在复杂行为和精神病研究中的培训。它贡献了“临界质量”，为学员和我们创造了令人兴奋和令人兴奋的研究环境。