Social_affiliation_and_alcohol_drinking_in_rodents

啮齿类动物的社交关系和饮酒

• 批准号: 8461701
• 负责人: Andrey E Ryabinin
• 金额: $ 25.78万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8461701
• 关键词: Acoustics; Address; Agreement; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Animal Model; Animals; Behavior; Binding; Biological; Brain region; Communication; Complex; Effectiveness; Exhibits; Genes; Genetic Polymorphism; Hearing; Heavy Drinking; Housing; Human; Intake; Laboratory Rat; Laboratory mice; Length; Measures; Microsatellite Repeats; Microtus; Modeling; Monitor; Naltrexone; Narcotic Antagonists; Opiates; Outcome; Pair Bond; Pattern; Pharmacotherapy; Play; Regulation; Relapse; Rodent; Rodent Model; Role; Saccharin; Social Environment; System; Testing; Therapeutic; Time; Tissue Sample; Tube; Ultrasonics; Vasopressins; Water; Work; alcoholism pharmacotherapy; alcoholism therapy; base; behavior prediction; drinking; drinking behavior; endogenous opioids; experience; insight; member; prairie vole; preference; prevent; promoter; public health relevance; research study; social; success; treatment strategy; vocalization

DESCRIPTION (provided by applicant): Social affiliations play an important role in the onset and relapse of alcoholism and heavy drinking, yet this aspect of alcoholism and alcohol abuse has not been successfully modeled in rodents. Recently we developed the use of prairie voles (Microtus ochrogaster) to study negative (facilitating) and positive (inhibitory) social influences on alcohol consumption. Specifically, we demonstrated alcohol preference and heavy ethanol intake in this species, and showed that pair-housed prairie voles influence each other's drinking. When voles are introduced to alcohol in pairs they exhibit higher alcohol preference than when they are introduced to alcohol being single-housed. In these pairs, one vole influences (i.e., increases) alcohol consumption of its partner - modeling facilitating influences on alcohol drinking. In contrast, during pairing of high- and low-drinking voles that have previously experienced alcohol when they were single- housed, the vole with higher basal intake tends to decrease its drinking thereby matching its partner - modeling inhibitory social influences. Thus, the prairie vole could serve as the first rodent model of the effects of specific inter-personal affiliations on high alcohol drinking in both directions. We hypothesize that prairie voles influence their partner's rate of alcohol consumption via acoustic communication as do humans and that this influence is regulated by dominant/submissive relations, the opiate and the vasopressin (AVP) systems. We propose to test this hypothesis through following four Specific Aims. Specific Aim 1: To test whether the social influences on alcohol drinking occur by synchronizing alcohol drinking and are influenced by dominant-submissive interactions. Specific Aim 2: To test the whether USVs contribute to coordinated drinking in voles further increasing the validity of our model. Specific Aim 3: To test whether the efficacy of an established pharmacotherapy of alcoholism targeting the endogenous opiate system is modulated by social influences. Specific Aim 4: To test whether the AVP system known to regulate social affiliations in prairie voles contributes to regulation of coordinated drinking. Taken together this work will for the first time reveal information on the biological mechanisms regulating social influence on excessive alcohol drinking in a rodent model.

描述（由申请人提供）：社会关系在酗酒和酗酒的发生和复发中发挥着重要作用，但酗酒和酗酒的这一方面尚未在啮齿类动物中成功建模。最近，我们开发了利用草原田鼠（Microtus ochrogaster）来研究对饮酒的负面（促进）和正面（抑制）社会影响。具体来说，我们证明了该物种的酒精偏好和大量乙醇摄入，并表明配对饲养的草原田鼠会影响彼此的饮酒。当田鼠成对接触酒精时，它们比单独饲养时表现出更高的酒精偏好。在这些配对中，一只田鼠影响（即增加）其伴侣的饮酒量——模拟促进对饮酒的影响。相比之下，在单居时曾经历过酒精的高饮酒量和低饮酒量的田鼠配对时，基础摄入量较高的田鼠往往会减少饮酒，从而与其伴侣相匹配——模拟抑制性社会影响。因此，草原田鼠可以作为第一个啮齿动物模型，研究特定人际关系对高酒精饮酒的双向影响。我们假设草原田鼠像人类一样通过声音交流影响其伴侣的饮酒率，并且这种影响受到主导/服从关系、鸦片和加压素（AVP）系统的调节。我们建议通过以下四个具体目标来检验这一假设。具体目标 1：测试对饮酒的社会影响是否通过同步饮酒而发生，并受到主导-顺从相互作用的影响。具体目标 2：测试 USV 是否有助于田鼠协调饮水，进一步提高我们模型的有效性。具体目标 3：测试针对内源性阿片系统的既定酒精中毒药物疗法的疗效是否受到社会影响的调节。具体目标 4：测试已知调节草原田鼠社会关系的 AVP 系统是否有助于调节协调饮酒。总而言之，这项工作将首次揭示在啮齿动物模型中调节社会对过度饮酒影响的生物机制的信息。