Mechanisms of sensorineural hearing loss: secreted factors

感音神经性听力损失的机制：分泌因素

基本信息

批准号：
9352311
负责人：
Konstantina M Stankovic
金额：
$ 42.5万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-13 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9352311
关键词：
Acoustic Nerve Acoustic Neuroma Acoustic Trauma Acute Affect Aminoglycosides Anatomy Animal Model Animals Apoptosis Audiometry Auditory Autopsy Biochemical Cavia Chronic Clinical Computers Core Facility Custom Data Ear Educational process of instructing Enzyme-Linked Immunosorbent Assay Equilibrium Event Eye FDA approved FGF2 gene Facial paralysis Floor Functional disorder Future Gene Targeting Generations Hair Cells Hearing Histologic Hospital Referrals Hospitals Human Immune Immunohistochemistry In Vitro Internet Intracranial Neoplasms Ipsilateral Laboratories Light Linear Regressions Liquid substance Massachusetts Measurement Measures Mechanics Mediating Mediator of activation protein MicroRNAs Modeling Molecular Mus Nerve compression syndrome Neurons Non-Malignant Outer Hair Cells Pathology Pathway interactions Patient Care Patients Personal Computers Pharmaceutical Preparations Pharmacology Pharmacotherapy Physiological Pilot Projects Proteins Radiology Specialty Research Resources Reverse Transcriptase Polymerase Chain Reaction Role Sampling Schwann Cells Secondary to Sensorineural Hearing Loss Severities Signal Transduction Synapses System TNF gene Temporal bone structure Testing Time Tinnitus Toxic effect Translations Vestibular Nerve Viral Viral Vector Work animal care clinical Diagnosis clinically relevant deafness design experimental study hearing impairment in vivo insight medical schools member neurophysiology novel otoacoustic emission ototoxicity prevent square foot targeted treatment tumor necrosis factor-alpha inhibitor

项目摘要

Resources Facilities The Eaton-Peabody Laboratories (EPL) at the Massachusetts Eye and Ear Infirmary (MEEI) occupies ~10,000 sq ft, 2500 sq ft and 2000 sq ft on floors 4, 6 and 3, respectively. The laboratory is fully equipped for neurophysiological, anatomic, histologic, immunohistochemical and molecular studies. Clinical The Masschusetts Eye and Ear Infirmary is a tertiary referral hospital and a teaching affiliate of Harvard Medical School. The hospital has state of the art facilities for care of patients with hearing loss. Animal There is a fully equipped animal care facility at MEEI, which includes two animal rooms (~400 sq. ft. each) reserved for use by members of EPL. The facility also includes rooms for acute and chronic animals. Computer Personal computers with internet access are available throughout the EPL. Computer facilities are maintained by full time computer programmer and systems analysts. Office The P.I. has a 200 sq ft office at MEEI adjacent to her dedicated laboratory space of ~1000 sq ft. Other The P.I. has access to the viral core facility at Massachusetts Eye and Ear. The core facility is fully equipped for customized viral vector design.

资源设施马萨诸塞州眼和耳科医院（MEEI）的Eaton-Peabody Laboratories（EPL）占据了约10,000 地板4、6和3上的平方英尺，2500平方英尺和2000平方英尺。实验室已设备齐全神经生理，解剖学，组织学，免疫组织化学和分子研究。临床 Masschusetts Eye and Ear医务院是三级转诊医院和哈佛大学的教学分支机构医学院。该医院设有护理损失患者的最先进的设施。动物 MEEI有一个设备齐全的动物护理设施，其中包括两个动物室（每个动物室）保留供EPL成员使用。该设施还包括用于急性和慢性动物的房间。电脑在EPL中提供具有Internet访问的个人计算机。维护计算机设施由全职计算机程序员和系统分析师作者。办公室 P.I.在她的专用实验室空间约1000平方英尺附近的MEEI设有200平方英尺的办公室。其他 P.I.可以在马萨诸塞州的眼睛和耳朵上使用病毒核心设施。核心设施设备齐全用于定制的病毒矢量设计。