Project 2, Establishing a Community Cohort to Assess Risk of Oral Cancer in the Washington, D.C. Minority Population

项目 2，建立社区队列来评估华盛顿特区少数族裔人口的口腔癌风险

• 批准号: 9341170
• 负责人: Indra Z Mustapha
• 金额: $ 5.59万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9341170
• 关键词: African American; Area; Assessment tool; Awareness; Biopsy; Cancer Center; Cancerous; Cells; Centers for Disease Control and Prevention (U.S.); Clinical Research; Collaborations; Collection; Communities; Community Dentistry; Country; Data; Data Analyses; Databases; Dental; Dental Care; Dentists; District of Columbia; Early Diagnosis; Focus Groups; Future; Grant; Group Interviews; Health; Health Fairs; Health Personnel; Health Status; Health education; Healthcare; Hemorrhage; High Prevalence; Human Papillomavirus; Incidence; Individual; Inflammation; Lead; Lesion; Location; Malignant Neoplasms; Medical; Minority; Modeling; National Health and Nutrition Examination Survey; Oral; Oral health; Patients; Pharyngeal structure; Phase; Population; Population Analysis; Precancerous Conditions; Premalignant; Prevalence; Provider; Recruitment Activity; Risk; Sample Size; Screening for Oral Cancer; Survival Rate; Techniques; Tooth structure; Universities; Visual; Washington; base; cancer diagnosis; cohort; college; community center; improved; malignant mouth neoplasm; minority communities; oral HPV; oral cancer prevention; oral care; oral dysplasia; oral lesion; programs; screening

Project 2- Abstract The incidence of oral cancer in minorities residing in Washington, D.C. are the highest in the country, (CDC, June 2012); While intra-oral exams may detect precancerous lesions with visual examination, HPV-associated oral cancer is found predominantly in the pharynx, a location not easily accessible during intra-oral exam. Furthermore, a high proportion of individuals in the community are not currently under routine medical or dental care. Therefore, we aim to establish a pilot community cohort to study association between oral health status, factors influencing barriers to oral care and oral pre- cancerous conditions and oral cancerous lesions. Our hypothesis is that the minority population in the Washington DC displays a higher prevalence of precancerous oral lesions and HPV-positivity than the general US population, and possesses barriers to receiving routine oral health care and oral cancer screenings. Our Specific Aims are: 1) To conduct a qualitative study engaging stakeholders and a focus group to identify barriers and needs of oral health care and oral cancer prevention in the DC minority community. 2) To establish a pilot cohort of patients in the local Washington DC minority community to determine the prevalence of pre-cancerous oral lesions and prevalence of HPV sub-types using brush biopsy and oral rinse techniques of cell collection, respectively, 3) To determine the association of periodontal inflammation with oral precancerous lesions, oral cancer, HPV positivity, and HPV-associated oral cancer in the US population by analyzing the NHANES data. If our program is successful, this project will serve as a model for a larger screening and clinical research program in the future and lead to additional grants. In the long-term, our study has at least 3 implications: 1) it will underscore the importance of oral cancer screening by dental providers in the Washington D.C. population; 2) it will increase the awareness of the importance of referrals to dentists for oral cancer screenings, and ultimately, 3) it will improve survival rates for those with oral cancer by early detection and routine oral cancer screening and improved oral health education and treatment.

项目2-摘要 居住在华盛顿特区的少数民族口腔癌的发生率最高 该国（CDC，2012年6月）；虽然口腔内检查可能检测到癌前病变 通过视觉检查，主要发现与HPV相关的口腔癌 咽部，在口腔内检查期间不容易到达位置。此外，高 社区中个人比例目前尚未接受常规医疗或 牙科护理。因此，我们旨在建立一个试点社区人群来学习协会 在口腔健康状况之间，影响口腔护理障碍的因素和口腔前的障碍 癌状况和口腔癌病变。我们的假设是少数 华盛顿特区的人口显示出较高的癌前口腔患病率 与美国一般人群相比，病变和HPV积极性 接受常规的口腔医疗保健和口腔癌筛查。我们的具体目的是：1） 进行定性研究，参与利益相关者和一个焦点小组以识别 DC少数族裔口腔卫生保健和预防口腔癌的障碍和需求 社区。 2）在华盛顿特区少数民族中建立一个患者的飞行员队列 社区确定癌前口腔病变的患病率和患病率 使用刷子活检和细胞收集的口服冲洗技术的HPV子类型， 分别为3）确定牙周炎症与口服的关联 癌前病变，口腔癌，HPV阳性和与HPV相关的口腔癌 美国人口通过分析NHANES数据。如果我们的计划成功了，那么 项目将作为大型筛查和临床研究计划的模型 未来并导致额外的赠款。从长远来看，我们的研究至少有3个 含义：1）它将强调牙齿口腔癌筛查的重要性 华盛顿特区人口的提供者； 2）它将提高对 转介给牙医对口腔癌筛查的重要性，最终，3）它将 通过早期检测和常规口服提高口腔癌患者的存活率 癌症筛查并改善了口腔健康教育和治疗。