NeuroLab M3: Discovery-based explorations of scientific models, model organisms,

NeuroLab M3：基于发现的科学模型、模型生物、

• 批准号: 9284538
• 负责人: Ralph Imondi
• 金额: $ 20.5万
• 依托单位: COASTAL MARINE BIOLABS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284538
• 关键词: Address; American; Animal Model; Applied Research; Area; Award; Axon; Behavior; Biological; Biological Models; Biological Process; Biomedical Research; California; Career Choice; Cellular biology; Collaborations; Communication; Communication Research; Communities; County; Data; Databases; Defect; Development; Developmental Biology; Dimensions; E-learning; Educational Curriculum; Embryonic Development; Exhibits; Fostering; Funding; Future Teacher; Game Based Learning; Goals; Health Sciences; High School Faculty; High School Student; Image; Immersion Investigative Technique; Immunology; Institutes; Institution; Instruction; Internships; Knowledge; Laboratories; Laboratory Research; Learning; Los Angeles; Memory impairment; Mission; Modeling; Molecular Biology; Nervous system structure; Neurobiology; Neuromuscular Diseases; Neurons; Neurosciences; Neurosciences Research; Next Generation Science Standards; Oceanography; Outcome; Participant; Performance; Population; Process; Public Domains; Research; Research Institute; Resources; Science; Scientist; Series; Societies; Spinal cord injury; Students; Supervision; Teaching Method; Technology; United States National Institutes of Health; Universities; Vision; Visual; Work; base; biomedical scientist; cancer type; career; cell type; comparative; data sharing; education research; educational atmosphere; eleventh grade; evidence base; expectation; experience; follow-up; functional genomics; hands-on learning; information framework; innovation; interest; learning progression; lectures; microscopic imaging; model building; nervous system development; neurodevelopment; neuroinformatics; novel; program dissemination; programs; public health relevance; research based learning; research study; skills; success; teacher; theories; tool; transgene expression; vision science

DESCRIPTION (provided by applicant): NeuroLab M3 is a comprehensive research education program that carefully guides high school students through an interrelated series of in-depth, interdisciplinary, and discovery-based explorations of scientific models, model organisms, and model systems in developmental neuroscience. Supported by a broad and inclusive professional partnership network consisting of top-flight biomedical research scientists, neuroinformaticians, and educational media and science communication experts, the program delineates a coherent and thoughtfully conceived learning progression that engages students in core scientific practices within and among distinct but interrelated research-based learning environments. Immersive residential research institutes in comparative functional genomics will engage 150 high school students in a complete and integrated scientific workflow that provides novel opportunities for them to expand the repertoire of tools that are currently available for scientists to investigate fundamental aspects of neural development, including neuronal specification and axon pathfinding. Through our collaboration with the Neuroscience Information Framework, a broad-scale neuroinformatics and resource access initiative enabled by the NIH Blueprint, the NeuroLab M3 program also presents new opportunities for students to meaningfully partake in the practices of data sharing, management, annotation, and analytics. More specifically, in addition to generating authentic and novel scientific data that is of practicl value to the biomedical research community, students will disseminate their findings through a public-access image resource database that is jointly maintained by the American Society for Cell Biology and the National Center for Microscopy and Imaging Research. Residential research experiences hosted at our harbor-based learning laboratory will constitute part of a student learning progression that culminates in 8-week university research internships offered through a regional network of biomedical partner laboratories at the University of California (UC), Los Angeles, California Institute of Technology, UC Irvine, Salk Institute for Biological Studies, UC, San Diego, and Scripps Institution of Oceanography. Collectively, these experiences are intended to stimulate and bolster interest in biomedical career pathways, foster realistic career expectations, cultivate an understanding of crosscutting concepts and core scientific practices, and enhance science process skills. A third project component seeks to achieve many of these outcomes by engaging large numbers of teachers and students in the use of an innovative, game-based learning interactive that leads them through the basic to applied research continuum and into visually compelling explorations of the scientific model-building enterprise. Developed in collaboration with NSF award-winning gaming experts, this public-access resource will employ an embedded suite of cutting-edge assessment metrics, data tracking tools, and other analytics to evaluate how students collect, analyze, assimilate, and apply new knowledge to complete interactive missions organized around basic neuroscience research and current models of axon pathfinding.

描述（由申请人提供）：Neurolab M3是一项全面的研究教育计划，该计划仔细指导高中生，通过一系列相互关联的深度，跨学科和基于发现的科学模型，模型有机体和模型系统系统的探索。该计划在由顶级生物医学研究科学家，神经信息学家以及教育媒体和科学传播专家组成的广泛而包容的专业合作伙伴网络的支持下，该计划描述了一个连贯且周到的学习进步，使学生在内部和相关的基于研究的研究环境中吸引学生参与核心科学实践。比较功能基因组学中的沉浸式住宅研究机构将与150名高中学生一起参与完整而综合的科学工作流程，为他们提供了新的机会，为他们提供了扩大工具的曲目，这些工具目前可用于研究神经元间的基本方面，包括神经元规范规范和轴突探测。通过与NIH BluePrint启用的广泛神经信息和资源访问计划的合作，Neurolab M3计划还为学生提供了有意义地参与数据共享，管理，注释，注释和分析的实践的新机会。更具体地说，除了生成对生物医学研究界具有实践价值的真实和新颖的科学数据外，学生还将通过公共访问图像资源数据库来传播他们的发现，该数据库由美国细胞生物学学会和国家微观生物学中心共同维护。在我们港口的学习实验室举办的住宅研究经验将构成学生学习进步的一部分，该进步是通过加利福尼亚大学洛杉矶大学洛杉矶大学（UC）的加利福尼亚大学洛杉矶分校的生物医学合作伙伴实验室（UC），加利福尼亚州科技研究所，UC Irvine Institation，UC Irvine Institation，UC Institutity for Giodication for San San Dogo，UC和SCRCRIPP，SCRCRIPP和SCRCRIPP。总的来说，这些经验旨在激发和增强对生物医学职业途径的兴趣，促进现实的职业期望，培养对跨界概念和核心科学实践的理解，并提高科学过程。第三个项目组成部分试图通过吸引大量的教师和学生使用创新的，基于游戏的学习互动来实现许多结果，从而使他们通过基本的应用研究连续性，并进入对科学模型建设企业的视觉上令人信服的探索。该公共访问资源将与NSF屡获殊荣的游戏专家合作开发，将采用嵌入式尖端评估指标，数据跟踪工具和其他分析的嵌入式套件，以评估学生如何收集，分析，化合物，化合物，并应用新知识，以完成围绕基本神经科学研究和当前模型的轴突轴突路径模型组织的互动使命。