Wadsworth Center's Children's Health Exposure Assessment Resource (WC-CHEAR)

沃兹沃斯中心的儿童健康暴露评估资源 (WC-CHEAR)

基本信息

批准号：
9563496
负责人：
Kenneth M. Aldous
金额：
$ 208万
依托单位：
WADSWORTH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2019-09-04
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9563496
关键词：
Accreditation Affect Androgens Aromatic Polycyclic Hydrocarbons Biochemistry Bioinformatics Biological Biological Monitoring Biomedical Research Blood CLIA certified Cerebrospinal Fluid Chemicals Child Child Support Child health care Cholesterol Clinical Clinical Chemistry Collection Communities Complement Complex Coupled Custom Data Analyses Development Electrolytes Endocrine Disruptors Ensure Environment Environmental Exposure Environmental Health Environmental Pollution Estradiol Estrogens Exposure to Flame Retardants Folic Acid Funding Goals Hair Heavy Metals Homocysteine Hormones Human Human Resources Insecticides Insulin International Laboratories Laboratory Research Leadership Mass Spectrum Analysis Measurement Measures Medicine Methods Molecular Nail plate National Institute of Environmental Health Sciences New York Organic Chemicals Organophosphates Pattern Pesticides Pharmacology Phenols Placenta Plasma Poison Polychlorinated Biphenyls Population Protocols documentation Provider Public Health Research Research Institute Research Personnel Resources Role Saliva Sampling Serum Services Spottings Sweat Techniques Testing Testosterone Thyroid Gland Tooth structure Trace Elements Triglycerides Umbilical Cord Blood United States National Institutes of Health Universities Urine Vitamin B 12 Vitamin D Vitamins Whole Blood base clinical toxicology environmental stressor experience interest international center laboratory facility medical schools novel novel strategies organic contaminant phthalates programs protein biomarkers protein metabolite public health relevance pyrethroid research facility research study response sample collection scientific organization temporal measurement toxic metal

项目摘要

DESCRIPTION (provided by applicant): The overall objective of the Wadsworth Center's Children's Health Exposure Analysis Resource (WC-CHEAR) is to establish a world-class laboratory facility that will serve the needs of NIH-funded investigators conducting research studies into the effects of environmental contaminants on children's health. The WC-CHEAR will bring together the tremendous resources, capabilities and expertise of the NY State Department of Health's public health laboratory and biomedical research facilities in Albany, NY with those of the NYU School of Medicine, Department of Biochemistry and Molecular Pharmacology. Together, this partnership between Wadsworth and NYU will provide researchers with access to state-of-the-art, specialized analytical facilities to support children's environmental health studies. The Wadsworth Center's is fully accredited under CLIA-88, and can support multiple NIH-funded studies, where children's urine and/or serum will be analyzed for organic chemical contaminants including, but not limited to, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, fluorinated compounds, brominated flame retardants, organophosphate insecticides, phenolic endocrine disrupting chemicals, and phthalates using techniques based on mass spectrometry. The laboratories are also able to analyze children's biospecimens for exposure to toxic heavy metals including, but not limited to, Pb, Cd, Hg, and As using the most sensitive methods available based on inorganic mass spectrometry. The laboratories are also able to analyze children's blood, serum/plasma, and urine for endogenous compounds including hormones, vitamins, protein markers, electrolytes and metabolite panels (including but not limited to estrogens, androgens, testosterone, thyroid panels, triglycerides, cholesterol, vitamin D and B12, folate, homocysteine and insulin) that may be affected by environmental exposures. Wadsworth provides extensive capabilities for analyzing non-traditional matrices such as placenta, cord blood, baby teeth, dried blood spots, hair, nails, and saliva for organic and inorganic contaminants to support novel approaches to measure children's exposure to toxic chemicals in their environment. Capability and expertise for investigating untargeted compounds will be shared between Wadsworth and NYU, where their extensive capabilities complement each other. The WC-CHEAR will benefit from the Wadsworth Center's international reputation and leadership in the field of clinical laboratory medicine, and as an organizer of proficiency testing (PT) programs in environmental laboratory medicine, clinical chemistry and toxicology. The experience and capability that Wadsworth brings in this regard will provide the NIEHS Children's Health Environmental Analytical Resource (CHEAR) network with a PT program customized to support biomonitoring studies and the needs of the network. The CHEAR PT program developed at Wadsworth will produce well-characterized, matrix-based reference materials containing exogenous and endogenous analytes of interest at critical concentration ranges relevant to biomonitoring that will be shared across the CHEAR lab network.

描述（由申请人提供）：沃兹沃斯中心儿童健康暴露分析资源 (WC-CHEAR) 的总体目标是建立一个世界一流的实验室设施，以满足 NIH 资助的研究人员对以下因素的影响进行研究的需求： WC-CHEAR 将汇集纽约州卫生部公共卫生实验室和位于纽约州奥尔巴尼的生物医学研究机构的巨大资源、能力和专业知识。沃兹沃斯与纽约大学医学院生物化学和分子药理学系的合作将为研究人员提供最先进的专业分析设施，以支持儿童环境健康研究。该中心获得 CLIA-88 的完全认可，可以支持多项 NIH 资助的研究，其中将分析儿童尿液和/或血清中的有机化学污染物，包括但不包括仅限于多氯联苯、多环芳烃、氟化化合物、溴化阻燃剂、有机磷杀虫剂、酚类内分泌干扰化学品和邻苯二甲酸盐，实验室还能够使用基于质谱的技术分析儿童生物样本的有毒重金属暴露情况。使用基于可用的最灵敏方法检测（但不限于）Pb、Cd、Hg 和 As实验室还能够分析儿童血液、血清/血浆和尿液中的内源性化合物，包括激素、维生素、蛋白质标记物、电解质和代谢物组（包括但不限于雌激素、雄激素、睾酮、甲状腺组、甘油三酯、胆固醇、维生素 D 和 B12、叶酸、同型半胱氨酸和胰岛素）Wadsworth 提供了广泛的非传统分析功能。胎盘、脐带血、乳牙、干血斑、头发、指甲和唾液等有机和无机污染物的基质，以支持测量儿童在其环境中接触有毒化学物质的新方法。研究非目标化合物的能力和专业知识。沃兹沃斯中心与纽约大学共享，两者的广泛能力相辅相成，沃兹沃斯中心在临床实验室医学领域的国际声誉和领导地位将受益于该中心的组织者。环境实验室医学、临床化学和毒理学方面的能力验证 (PT) 项目 Wadsworth 在这方面带来的经验和能力将为 NIEHS 儿童健康环境分析资源 (CHEEAR) 网络提供定制的 PT 项目，以支持生物监测研究和环境分析。 Wadsworth 开发的 CHEAR PT 计划将产生特征良好、基于基质的参考材料，其中包含与相关临界浓度范围相关的外源性和内源性分析物。生物监测将在 CHEAR 实验室网络中共享。