ECOG-ACRIN Operations Center

ECOG-ACRIN 运营中心

基本信息

批准号：
9482040
负责人：
ROBERT L COMIS
金额：
$ 39.4万
依托单位：
ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-29 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9482040
关键词：
Adult American College of Radiology Imaging Network Bioinformatics Biological Markers Biological Response Modifier Therapy Biometry Cancer Biology Cancer Center Cancer Patient Cancer Research Network Caring Center for Translational Science Activities Clinical Clinical Data Clinical Informatics Clinical Research Clinical Trials Collaborations Communities Continuity of Patient Care Coupled Dana-Farber Cancer Institute Data Databases Development Diagnostic Diagnostic Imaging Discipline Early Diagnosis Eastern Cooperative Oncology Group Extramural Activities Fostering Funding Goals Image Information Technology Institute of Medicine (U.S.)Institution Intervention Investigation Joints Laboratories Leadership Malignant Neoplasms Minority Monitor National Cancer Institute National Clinical Trials Network Outcome Patient advocacy Patients Phase Population Positioning Attribute Public Health Rare Diseases Reporting Research Research Infrastructure Research Personnel Resources Risk Science Specialized Program of Research Excellence Specimen Subgroup System Tissue imaging Translating Translational Research Translations Universities Validation advanced disease base bench to bedside biobank cancer care cancer therapy cancer type career development clinical care clinical imaging clinical practice comparative effectiveness data management design effectiveness research experience imaging modality improved improved outcome member molecular diagnostics multimodality named group operation programs response scientific organization standard of care treatment effect

项目摘要

DESCRIPTION (provided by applicant): Clinical trials continue to be a cornerstone to the effort to advance care and improve outcomes for cancer patients. ECOG and ACRIN collectively have over 65 years of experience conducting high impact clinical trials that have helped shaped clinical practice. In response to the National Clinical Trials Network (NCTN) initiative, ECOG and ACRIN have merged their complementary scientific programs to form the ECOG-ACRIN Cancer Research Group (E-A). We propose a program focused on the efficient development and implementation of practice-changing science along the cancer care continuum from early detection through treatment of advanced disease. We take advantage of combined expertise in imaging, cancer biology and therapy within our scientific organization, working closely with the biostatistics and data management center at the Dana Farber Cancer Institute and Brown University, to propose a portfolio of treatment and advance imaging trials that recognize the importance of biomarkers to identify appropriate patient subgroups for precisely targeted intervention. The E-A biorepositories, image database and associated translational science centers will leverage the data collected in the context of trials to perform correlative science studies that advance our understanding of cancer biology and treatment effect. We continue to seamlessly integrate with Cancer Center and SPORE research programs to create an interface for translating NCI-supported science into clinical trials and to attract junior investigators intothe NCTN. We propose to continue collaborating across the NCTN, contributing high quality trials, leadership in advance imaging, joint trial development and important NCTN operational infrastructure. E-A will leverage unique clinical informatics expertise to contribute a data warehouse of annotated images and specimens, laboratory analytics and clinical data to foster scientific discovery. E-A will contribute an accrual network of 37 main member institutions, 200 affiliates, 36 CCOPs and minority-based CCOPs that have accrued 33750 patients to clinical trials over the last 6 years. E-A is positioned to make unique contributions to the NCTN, working to translate NCI-supported science into improved outcomes for cancer patients. RELEVANCE: The primary goal of ECOG-ACRIN is to provide the support necessary to conduct relevant and rigorous clinical trials, which benefit public health by improving the quality and standard of care for cancer patients.

描述（由申请人提供）：临床试验仍然是努力提高护理和改善癌症患者结果的基石。 ECOG和ACRIN共同拥有超过65年的经验，这些经验有助于塑造临床实践，从而进行了高影响力的临床试验。为了回应国家临床试验网络（NCTN）倡议，ECOG和ACRIN已合并其互补的科学计划，以组成ECOG-ACRIN癌症研究小组（E-A）。我们提出了一项计划，重点介绍从早期检测到治疗晚期疾病的有效发展和改变实践改变科学的计划。我们利用科学组织内的成像，癌症生物学和治疗方面的联合专业知识，与Dana Farber癌症研究所和Brown University的生物统计学和数据管理中心紧密合作，提出了一项治疗和预先成像试验的组合，以认识到生物标志物的重要性，以确定生物标志物以确定适当的患者对精确靶向的干预措施。 E-A生物震荡，图像数据库和相关的翻译科学中心将利用试验中收集的数据来执行相关的科学研究，以提高我们对癌症生物学和治疗效果的理解。我们继续与癌症中心和孢子研究计划无缝集成，以创建一个将NCI支持的科学转化为临床试验的界面，并吸引了初级研究人员在NCTN中。我们建议继续在整个NCTN进行合作，贡献高质量的试验，提前成像，联合试验开发和重要的NCTN运营基础设施。 E-A将利用独特的临床信息学专业知识来贡献带注释的图像和标本，实验室分析和临床数据的数据仓库，以促进科学发现。 E-A将贡献一个由37个主要成员机构，200个分支机构，36个CCOP和少数族裔CCOPS组成的应计网络，这些网络已在过去6年中累积了33750名患者进行临床试验。 E-A可以为NCTN做出独特的贡献，致力于将NCI支持的科学转化为癌症患者的改善结果。相关性：ECOG-ACRIN的主要目标是提供进行相关和严格临床试验所需的支持，这些试验通过改善质量而受益于公共卫生和癌症患者的护理标准。