Adolescent Screener and Opioid Assessment for Patients with Pain (A-SOAPP)

针对疼痛患者的青少年筛查和阿片类药物评估 (A-SOAPP)

基本信息

批准号：
8712755
负责人：
Kimberlee Jean Trudeau
金额：
$ 19.48万
依托单位：
INFLEXXION, INC.
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8712755
关键词：
Accounting Achievement Adolescent Adult Age Alcohol or Other Drugs use Behavior Behavioral Boston Cancer Patient Caregivers Categories Childhood Clinical Cognitive Complex Cystic Fibrosis Data Development Etiology Evaluation Exercise Goals Health Personnel Hemophilia A Individual Institution Interview Letters Malignant Neoplasms Medical Medical History Methods Minority Modeling Monitor Opioid Opioid Analgesics Organ Transplantation Outcome Pain Pain management Parents Patient Self-Report Patients Pediatric Hospitals Pharmaceutical Preparations Phase Population Preventive screening Process Provider Psychometrics Recovery Recurrent pain Research Review Literature Risk Role Saint Jude Children&apos s Research Hospital Secondary pain Services Sickle Cell Anemia Sorting - Cell Movement Source Specialist Specific qualifier value Target Populations Testing Toxicology Transplantation Urine Youth addiction aged base chronic pain high risk innovation interest meetings member opioid misuse patient population pill predictive modeling prescription opioid public health relevance screening tool

项目摘要

DESCRIPTION (provided by applicant): Pain management including the use of opioid analgesics is recommended for adolescents who are suffering from recurrent or chronic pain associated with a specific etiology such as cancer, cystic fibrosis, sickle cell anemia, hemophilia or organ transplants (see citations by etiology in letter of support from CO-I, Dr. Solodiuk). Preventive screening tools provide information that can be used by the provider to inform prescription choices (use of opioid versus another medication) and subsequent monitoring (e.g., urine screens, pill counts), resulting in safe and effective pain management. Pediatric hospitals are currently using screeners developed and tested with other populations because there is no validated tool for this specific patient population. The primary aim of this application is to begi development of a screening tool called the Adolescent Screener and Opioid Assessment for Patients with Pain (A-SOAPP) for use with adolescent-aged patients with secondary, recurrent or chronic pain accompanying complex medical conditions like cancer. The A-SOAPP will fill a void that exists for a screening tool to help healthcare providers identify individuals who may be at increased risk for opioid misuse among those patients being considered for episodic or long-term opioid therapy, including cancer patients and patients with sickle cell disease. Similar to development of the adult version, a rigorous methodical approach will be employed to develop a screener with stable, high predictive validity. An adolescent version of such a screener presents significant psychometric challenges including item content that is age-appropriate, accounting for the role of caregivers in the administration and monitoring of medication use, and operationally defining indicators of aberrant medication-related behaviors and signs indicating possible addiction in this population. Thus, in addition to meeting an important clinical need, an age-appropriate, population-appropriate screener for opioid risk represents a significant innovation in the field. In our view, the achievement of this goal will require the concept of a "screener" to deviate from the self-report behavioral screeners typically used to detect or predict substance use problems. Rather, this screener will endeavor to capitalize on predictive relations of data from a variety of sources (e.g., provider observations, demographic information, medical history, as well as patient self-report), to best model and predict the outcome of interest, namely aberrant medication-related behaviors.

描述（由申请人提供）：对于患有与特定病因（例如癌症、囊性纤维化、镰状细胞性贫血、血友病）相关的复发性或慢性疼痛的青少年，建议进行疼痛管理，包括使用阿片类镇痛药或器官移植（参见CO-I，Solodiuk 博士的支持信中病因学的引文）。预防性筛查工具提供的信息可供提供者用来告知处方选择（使用阿片类药物与其他药物）和后续监测（例如尿液筛查、药丸计数），从而实现安全有效的疼痛管理。儿科医院目前正在使用针对其他人群开发和测试的筛查仪，因为没有针对该特定患者人群的经过验证的工具。该应用程序的主要目的是开始开发一种名为青少年疼痛患者筛查和阿片类药物评估 (A-SOAPP) 的筛查工具，用于患有继发性、复发性或慢性疼痛并伴有癌症等复杂疾病的青少年患者。 A-SOAPP 将填补筛查工具的空白，帮助医疗保健提供者在考虑接受间歇性或长期阿片类药物治疗的患者（包括癌症患者和镰状细胞病患者）中识别阿片类药物滥用风险增加的个体细胞疾病。与成人版本的开发类似，将采用严格的系统方法来开发具有稳定、高预测有效性的筛选器。这种筛查仪的青少年版本提出了重大的心理测量挑战，包括适合年龄的项目内容、考虑护理人员在管理和监测药物使用中的作用、以及在操作上定义异常药物相关行为的指标和表明可能成瘾的迹象在这个人群中。因此，除了满足重要的临床需求之外，适合年龄、适合人群的阿片类药物风险筛查代表了该领域的重大创新。我们认为，实现这一目标将需要“筛选器”的概念偏离通常用于检测或预测的自我报告行为筛选器物质使用问题。相反，该筛选器将努力利用各种来源（例如，提供者观察、人口统计信息、病史以及患者自我报告）的数据的预测关系，以最好地建模和预测感兴趣的结果，即与药物相关的异常行为。