The Jackson Laboratory Nathan Shock Center of Excellence in the Basic Biology of Aging

杰克逊实验室内森休克衰老基础生物学卓越中心

• 批准号: 9316402
• 负责人: Gary A Churchill
• 金额: $ 80.27万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316402
• 关键词: Advisory Committees; Aging; Alleles; Animal Model; Animals; Behavioral; Biological; Biology of Aging; Blood specimen; Caenorhabditis elegans; Caloric Restriction; Candidate Disease Gene; Collaborations; Communities; Complex; Data; Databases; Development; Diet; Disease; Ensure; Environmental Risk Factor; Experimental Designs; Funding; Gene Expression; Genes; Genetic; Genetic Code; Genetic Models; Genetic Research; Genetic Variation; Genetic screening method; Goals; Grant; Health; Human; Human Genetics; Human Genome; IT collaborator; Inbred Strain; Individual; Information Resources; Institution; Intervention Studies; Joints; Knockout Mice; Laboratories; Leadership; Link; Longevity; Maps; Mentors; Metabolic; Methods; Mus; Peer Review; Phenotype; Physiological; Pilot Projects; Polygenic Traits; Population; Principal Investigator; Process; Protocols documentation; Publications; Quality Control; Quantitative Trait Loci; Research; Research Personnel; Resources; Role; Sampling; Shock; Standardization; Statistical Data Interpretation; Statistical Methods; Structure; System; Techniques; Testing; The Jackson Laboratory; Time; Tissue Sample; Tissues; Translational Research; Validation; Variant; Work; age related; aged; aging gene; candidate validation; career development; comparative; disorder risk; experience; gene discovery; genetic analysis; genetic approach; genome wide association study; healthy aging; member; microbiome; mouse model; next generation; novel; phenome; phenotypic data; programs; public health relevance; research and development; screening; symposium; tool; trait; web site

DESCRIPTION (provided by applicant): Lifespan is a complex trait, influenced by many interacting polymorphic alleles and environmental factors that may accelerate or delay aging, reduce or increase disease risk and/or promote extended lifespan. Thus, assessing the role of genetic variation in aging requires an experimental strategy capable of modeling the genetic and biological complexity of human populations while allowing for efficient identification and validation of candidate genes. With this proposal, the JAX NSC seeks support to further develop and disseminate the next generation of genetic, statistical and information resources necessary to enable a systems-wide approach to understanding healthy aging. The JAX NSC has transformed aging research at JAX, providing central resources to support our investigators that have resulted in 38 peer-reviewed publications and several active grants in the last funding period. The Center has developed nascent regional and national resources for aging research, including genetic maps, novel statistical methods and aging mouse resources and tissues that support our numerous collaborations and external researchers. All JAX NSC data are publicly disseminated on the Mouse Phenome Database and the JAX NSC website, thus ensuring that the resources generated and expertise acquired through the Center are readily available to the aging research community. In this renewal, we will advance toward our goal by providing next-generation resources and support to aging investigators while leveraging JAX's unparalleled expertise in the large-scale identification and functional validation of complex polygenic traits i mice. Our Specific Aims are to: 1) Increase the diversity of mouse resources available for aging research, including a new large-scale intervention study to investigate gene-diet interactions in genetically diverse mouse populations; 2) Strengthen statistical tools and support available to the aging community; 3) Expand the use of genetic approaches to translational research in aging, namely through a robust screening pipeline for candidate human aging genes; 4) Expand the research focus on aging, healthspan and age-related diseases at JAX through a robust Research Development Core; and 5) Provide effective Center administration and enhance the utility of JAX NSC resources throughout the aging community. The Center will be led by a highly experienced team of Principal Investigators and Core Leaders who, together with JAX NSC members and with oversight from an External Advisory Board, will provide effective management to facilitate the goals and objectives of the Center. The Center will also leverage the unparalleled institutional resources, facilities and expertise of The Jackson Laboratory, a globally renowned institution for mouse genetics research, to enhance its goals and the utility of the resources it generates for the aging research community.

描述（由申请人提供）：寿命是一个复杂的特征，受许多相互作用的多态性等位基因和环境因素的影响，这些因素可能会加速或延迟衰老，降低或增加疾病风险和/或促进延长的寿命。因此，评估遗传变异在衰老中的作用需要一种实验策略，能够对人群的遗传和生物学复杂性进行建模，同时允许对候选基因的有效鉴定和验证。通过这项建议，JAX NSC寻求支持，以进一步发展和传播下一代的遗传，统计和信息资源，以实现全系统的方法来理解健康的衰老。 JAX NSC在JAX上改变了老化的研究，提供了中央资源来支持我们的调查人员，这些调查员在上一个融资期间获得了38个同行评审的出版物和几项活跃的赠款。该中心已经开发了新生的区域和国家资源，用于老化研究，包括遗传图，新颖的统计方法以及老鼠资源和组织，以支持我们的众多合作和外部研究人员。所有JAX NSC数据均在鼠标现象数据库和JAX NSC网站上公开传播，从而确保了通过该中心获得的资源和专业知识可供老龄化的研究社区获得。在这种续约中，我们将通过向老龄化调查人员提供下一代资源和支持，同时利用JAX在大规模识别和功能验证复杂多基因特征I小鼠方面的无与伦比的专业知识，迈向我们的目标。我们的具体目的是：1）增加可用于衰老研究的小鼠资源的多样性，包括一项新的大规模干预研究，以研究遗传多样的小鼠种群中的基因 - 偏见相互作用； 2）加强老化社区可用的统计工具和支持； 3）扩大遗传方法在衰老中转化研究的使用，即通过候选人衰老基因的强大筛查管道； 4）扩大研究重点是通过强大的研究开发核心在JAX处衰老，健康范围和与年龄有关的疾病； 5）提供有效的中心管理，并在整个老龄化社区中增强JAX NSC资源的实用性。该中心将由经验丰富的主要调查员和核心领导者团队领导，他们与JAX NSC成员一起，并与外部顾问委员会的监督，将提供有效的管理，以促进该中心的目标和目标。该中心还将利用杰克逊实验室的无与伦比的机构资源，设施和专业知识，这是一家全球著名的老鼠遗传学研究机构，以增强其目标及其为老化研究社区产生的资源的实用性。