Pre-mRNA Interference of VEGF Pathways in Ocular Angiogenesis

眼部血管生成中 VEGF 通路的前 mRNA 干扰

• 批准号: 8391552
• 负责人: BALAMURALI K AMBATI
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8391552
• 关键词: Affect; Age related macular degeneration; Albumins; Alternative Splicing; Binding; Blindness; Blood Vessels; Bruch' s basal membrane structure; CCL2 gene; Cells; Choroid; Choroidal Neovascularization; Clinical; Code; Complication; Cornea; Corneal Injury; Corneal Neovascularization; Custom; Development; Devices; Diabetes Mellitus; Diabetic Retinopathy; Elements; Event; Exons; Exudative age-related macular degeneration; Eye; Eye Injuries; Eye Part; Fluorescein; Genes; Genetic; Graft Rejection; Health; Homing; Injury; Integrin alphaVbeta3; Introns; Keratoplasty; Label; Lasers; Length; Macular degeneration; Malignant Neoplasms; Masks; Membrane; Messenger RNA; Modeling; Mus; Oligonucleotides; Oligopeptides; Outcome; Pathway interactions; Patients; Plasmids; Posterior eyeball segment structure; Protein Isoforms; RGD (sequence); RNA Splicing; Regulation; Rehabilitation therapy; Research; Retina; Retinal Neovascularization; Silicon Dioxide; Sister; Soldier; Spliceosomes; Structure; System; Techniques; Technology; Testing; Tissues; Transcend; Translating; Trauma; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factors; Veterans; Vision; Visual impairment; Wild Type Mouse; base; cancer therapy; combat; fighting; improved; mRNA Precursor; macula; nanoparticle; neovascular; novel; novel strategies; novel therapeutic intervention; ocular angiogenesis; prevent; public health relevance; receptor; receptor expression; restoration; retinal angiogenesis; retinal damage; small molecule

DESCRIPTION (provided by applicant): Dr. Ambati plans to continue his research into disrupting pathways of new blood vessel formation within cells; this will augment and possibly transcend the current therapies of blockade outside the cell. By using novel techniques to disrupt the gene messaging systems which communicate directions to form new blood vessels, this proposal has the potential of advancing therapies for a variety of blinding conditions, including injury to the cornea (the front part of the eye), diabetes damage to the retina, and macular degeneration. This could translate into improved outcomes for veterans who sustain eye injury and require corneal transplantation (as fighting blood vessel formation is essential to corneal transparency and preventing corneal transplant rejection), as well as improved vision for veterans with diabetic retinopathy and macular degeneration, which are the leading cause of blindness among older veterans. Further, this approach of fighting blood vessel formation by targeting key genetic events within the cell could have major beneficial applications to cancer.

描述（由申请人提供）： 安巴蒂博士计划继续研究破坏细胞内新血管形成的途径；这将增强并可能超越目前的细胞外封锁疗法。通过使用新技术破坏基因信息系统，该系统传达形成新血管的方向，该提案有可能推进各种致盲疾病的治疗，包括角膜损伤（眼睛的前部）、糖尿病损伤视网膜和黄斑变性。这可能会改善眼部受伤并需要角膜移植的退伍军人的治疗结果（因为阻止血管形成对于角膜透明度和防止角膜移植排斥至关重要），并改善患有糖尿病视网膜病变和黄斑变性的退伍军人的视力，这些是老年退伍军人失明的主要原因。此外，这种通过靶向细胞内关键遗传事件来对抗血管形成的方法可能对癌症有重大的有益应用。