Advances in contact lens materials to extend wear time for a new standard in vision correction and future medical devices

隐形眼镜材料的进步可延长佩戴时间，从而达到视力矫正和未来医疗设备的新标准

• 批准号: 9255935
• 负责人: Roman Domszy
• 金额: $ 22.5万
• 依托单位: INDUSTRIAL SCIENCE & TECHNOLOGY NETWORK
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9255935
• 关键词: 3-Dimensional; Acanthamoeba Keratitis; Address; Adolescent; Adverse effects; Affect; Appearance; Area; Astigmatism; Blood capillaries; Clinical Research; Complex; Contact Lenses; Convection; Cornea; Corneal Topography; Cosmetics; Devices; Dimensions; Drug Delivery Systems; Drug Monitoring; Dryness; Elderly; Emerging Technologies; Engineering; Environment; Eyeglasses; Film; Future; Gases; Generations; Glaucoma; Goals; Growth Factor; Health; Health Care Costs; Hormones; Hydrogels; Hydrophilic Contact Lenses; Hydrophobicity; Hyperopia; Hypoxia; Image; Infection; Inflammation; Laser In Situ Keratomileusis; Lead; Long-Term Effects; Measurable; Measures; Medical Device; Methods; Modality; Molds; Molecular Conformation; Monitor; Morphology; Myeloma Proteins; Myopia; Nanotechnology; Needles; Nutrient; Operative Surgical Procedures; Optics; Optometry; Oxygen; Patients; Peptides; Performance; Permeability; Phase; Photorefractive Keratectomy; Polymers; Polynomial Models; Population; Presbyopia; Printing; Problem Solving; Process; Production; Property; Proteins; Redness; Risk; Shapes; Silicon; Silicones; Structure; Surface; Surface Tension; Technology; Time; Vision; Visual; Visual Acuity; Water; antimicrobial drug; base; biomaterial compatibility; capillary; commercialization; copolymer; cost; design; improved; innovation; lens; molecular assembly/self assembly; monitoring device; novel; patient population; prototype; submicron; surface coating; surfactant; wasting

PROJECT SUMMARY Over the last two decades, the commercialization of silicone-hydrogel ("SiHy") composite technologies has led to new soft CLs that are more breathable, comfortable, and affordable, including in daily disposable versions which have considerably broadened the customer base, especially among younger generations. Despite these improvements, the major persistent problem facing contact lenses is their poor compatibility with ocular environment, particularly the tear film. While the softness of the new composite materials made lenses more comfortable by conforming better to the cornea, the resultant tight fitting considerably lowers the tear exchange rate in the post-lens tear film. In addition, the precision of lens design and fabrication, limited by the difficulties of the thermal expansion of a dual-domain (silicon and hydrogel) substrate, are adequate only for adjusting an image's focus, not its visual acuity caused by other higher- order optical aberrations. We propose to solve these issues by creating a novel contact lens material that will lead to a new best-in-class soft lens with significant improvements in vision correction, clarity and comfort, and wide applicability to numerous patient populations. This project will engineer the new generation of lens innovations based on several recent advances in material and fabrication nanotechnologies. The combined application of submicron morphology control, molecular self-assembly, and high-precision molding (as well as 3-D printing), will make future CL devices more precise, biocompatible, and versatile. We identified three major areas of improvement in CLs that will benefit from our implementation of such new emerging technologies: (a) Pre-synthesis of new silicone block-copolymers for higher-precision control of domain morphology during lens fabrication, (b) Application of high-precision fabrication and high-definition ("HD") design for correcting the spherical aberration of CLs, and (c) Engineering a novel design of lens material and surface coating for enhancing PLTF turnover to improve ocular health. The new product would widely replace current CLs for at least the 39 million patients in the US market, and likely expand this market significantly with new and valuable functions such as control of myopia progression for adolescents and night vision enhancements for the elderly (by high-precision control and high-definition design), as well as unprecedented comfort and biocompatibility (by new surface coating's enhancement of PLTF turnover). Further, the new level of comfort and extended wear time would solve one key challenge associated with current state-of-the-art in ocular drug delivery and monitoring devices, promoting our technology to a future platform for growing these applications to treat other large populations such as the 64 million glaucoma patients worldwide.

项目摘要 在过去的二十年中，有机硅Hydrogel（“ Sihy”）复合技术的商业化导致了新的 柔软的CLS更透气，舒适和负担得起，包括每日一次性版本 大大扩展了客户群，尤其是在年轻一代。尽管有这些改进， 隐形眼镜面临的主要持续问题是它们与眼部环境的兼容性不佳，尤其是 撕裂电影。虽然新复合材料的柔软度使镜片变得更加舒适。 角膜，最终的紧密配合大大降低了镜头后撕裂膜中的撕裂率。此外， 透镜设计和制造的精度，受双域热膨胀难度的限制（硅 和水凝胶）底物仅足以调整图像的焦点，而不是由其他较高的敏锐度引起的视力 订购光学畸变。我们建议通过创建一种新颖的隐形眼镜材料来解决这些问题 一种新的一流的柔软镜头，具有明显的视觉校正，清晰度和舒适性，并且很广泛 适用于众多患者人群。 该项目将根据材料的最新进展和 制造纳米技术。亚微米形态控制的联合应用，分子自组装， 和高精度成型（以及3-D打印），将使未来的CL设备更加精确，生物相容性，并且 多才多艺的。我们确定了CLS改进的三个主要领域，这将受益于我们对这种新的实施 新兴技术：（a）新的有机硅块聚合物的合成前，用于更高精确控制域 晶状体制造过程中的形态，（b）应用高精度制造和高清（“ HD”）设计 纠正CL的球形像差，以及（c）设计一种新颖的镜头材料和表面涂层设计的设计 增强PLTF营业额以改善眼部健康。 新产品将为至少在美国市场的3900万患者中广泛取代当前的CL，并且可能 通过新的和有价值的功能，例如对青少年的近视发展，可以大大扩展这个市场 以及对老年人的夜视增强（通过高精度控制和高清设计）以及 前所未有的舒适性和生物相容性（通过新的Surface Coating的增强PLTF营业额的增强）。此外， 新的舒适度和延长的磨损时间将解决与当前最新的一个关键挑战 在眼药输送和监测设备中，将我们的技术推广到将来的平台以种植这些平台 用于治疗其他大量人群的应用，例如全球6400万青光眼患者。