PHORA: A Clinical Decision Support Tool for Patients with Pulmonary Arterial Hypertension

PHORA：肺动脉高压患者的临床决策支持工具

基本信息

批准号：
9207492
负责人：
RAYMOND Louis Benza
金额：
$ 74.92万
依托单位：
ALLEGHENY-SINGER RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2021-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9207492
关键词：
Academia Address Algorithms Biomedical Engineering Caring Chronic Disease Clinical Clinical Decision Support Systems Clinical Trials Clinical Trials Design Communication Communities Computer software Consensus Data Data Set Databases Decision Making Decision Support Systems Development Diagnosis Disease Disease Management Early Diagnosis Education Equation Evolution Feedback Focus Groups Foundations Future Generations Goals Healthcare Heart failure Individual Industry Intention Intervention Investigational Drugs Knowledge Life Light Machine Learning Meta-Analysis Modeling Morbidity - disease rate Multicenter Trials Observational Study Outcome Patient risk Patient-Focused Outcomes Patients Pharmaceutical Preparations Physicians Pulmonary Hypertension Pulmonary Vascular Resistance Pulmonary vessels Quality of life Rare Diseases Registries Resources Risk Risk Assessment Standardization Statistical Methods Structure Surrogate Endpoint Testing Therapeutic Therapeutic Intervention Training Treatment Effectiveness Uncertainty Validation base clinical predictors cohort computer based statistical methods computer human interaction computer program computer science cost cost effective cost effectiveness data management data mining data modeling effective therapy hypertension treatment improved individual patient individualized medicine medical specialties mortality multidisciplinary novel therapeutics outcome prediction predictive modeling prognostic prognostic tool prospective prototype pulmonary arterial hypertension response shared decision making success support tools survival prediction theories time use tool usability user centered design user-friendly vascular abnormality

项目摘要

ABSTRACT This application seeks to develop a multi-platform clinical decision support system (CDSS) in pulmonary arterial hypertension (PAH) for physicians, PHORA (Pulmonary Hypertension Outcomes Risk Assessment), which can be used to: (a) guide therapeutic decisions and (b) optimize clinical trial design. We will achieve this goal by utilizing clinical trial data from several large databases of completed trials in PAH, an ongoing PAH registry (REVEAL), as well as observational sessions with physicians. The proposed aims co- create the CDSS with a multi-disciplinary group of specialties including: biomedical engineering, advanced PAH physicians, computer science (machine learning/data mining), human computer interaction, and allied health care experts. Our intention is to engage all stakeholders to achieve consensus and thereby assure the acceptance of PHORA into practice. Successful completion of this project will lay the foundation for a prospective, multi-center trial in which PHORA will be evaluated with respect to long-term patient outcomes. The ultimate aim is to disseminate this resource so as to improve the efficiency, efficacy, and cost- effectiveness of this treatment for PAH.

抽象的该应用程序旨在开发肺部多平台临床决策支持系统（CDSS）医师，phora的动脉高血压（PAH）（肺动脉高压结局风险评估），可用于：（a）指导治疗决策和（b）优化临床试验设计。我们将通过利用来自PAH的几个大型试验数据库的临床试验数据来实现这一目标，这是一个正在进行的PAH注册表（揭示）以及与医生的观察会议。拟议的目标共同使用多学科的专业组创建CDSS，包括：生物医学工程，高级 PAH医生，计算机科学（机器学习/数据挖掘），人类计算机互动和相关医疗保健专家。我们的目的是让所有利益相关者达成共识，从而确保接受Phora实践。成功完成该项目将为前瞻性，多中心试验将对长期患者结局进行评估。最终目的是传播该资源，以提高效率，功效和成本 - 这种治疗对PAH的有效性。