Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral

图像引导口腔光动力治疗 (PDT) 的低成本实现技术

基本信息

批准号：
9355108
负责人：
Jonathan P Celli
金额：
$ 92.47万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-19 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9355108
关键词：
Acacia Address Aminolevulinic Acid Area Asia Benchmarking Biological Models Biopsy Businesses Calibration Cancer Burden Cancer Etiology Cancer Patient Carcinogen exposure Caring Case Study Cellular Phone Cessation of life Charge Cheek structure Clinical Clinical Research Consultations Contrast Media Country Coupled Data Deglutition Dental Development Plans Devices Disease Early Intervention Economic Burden Education Eligibility Determination Engineering Fiber Goals Guidelines Hamsters Health Care Costs Health Services Accessibility Health Technology Healthcare Histology Hospitals Human Image Imaging technology Implant India International Lesion Light Location Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of cervix uteri Massachusetts Mastication Medical Modality Modeling Morbidity - disease rate Muslim population group Necrosis Nuts Operative Surgical Procedures Optical Instrument Optics Oral Oral cavity Output PUVA Photochemotherapy Pakistan Patients Performance Pharmacologic Substance Phase Photosensitization Physical Sufferings Physicians Population Provider Quality of life Radiation therapy Reporting Research Research Infrastructure Research Personnel Resources Rural Series Shapes Site Source Sri Lanka Surgeon Technology The Sun Tobacco Trainers Training Training Treatment Efficacy United States National Institutes of Health Universities Woman Work base cancer imaging cancer therapy clinical research site cost density design dimethylbenzanthracene engineering design experience experimental study fluorescence imaging follow-up global health image guided imaging capabilities in vivo industry partner instrumentation low and middle-income countries malignant mouth neoplasm medical schools men mortality novel therapeutics oncology oral dysplasia oral lesion physical science portability pre-clinical public health relevance rural area screening tissue phantom treatment response tumor validation studies

Acacia Address Aminolevulinic Acid Area Asia Benchmarking Biological Models Biopsy Businesses Calibration Cancer Burden Cancer Etiology Cancer Patient Carcinogen exposure Caring Case Study Cellular Phone Cessation of life Charge Cheek structure Clinical Clinical Research Consultations Contrast Media Country Coupled Data Deglutition Dental Development Plans Devices Disease Early Intervention Economic Burden Education Eligibility Determination Engineering Fiber Goals Guidelines Hamsters Health Care Costs Health Services Accessibility Health Technology Healthcare Histology Hospitals Human Image Imaging technology Implant India International Lesion Light Location Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of cervix uteri Massachusetts Mastication Medical Modality Modeling Morbidity - disease rate Muslim population group Necrosis Nuts Operative Surgical Procedures Optical Instrument Optics Oral Oral cavity Output PUVA Photochemotherapy Pakistan Patients Performance Pharmacologic Substance Phase Photosensitization Physical Sufferings Physicians Population Provider Quality of life Radiation therapy Reporting Research Research Infrastructure Research Personnel Resources Rural Series Shapes Site Source Sri Lanka Surgeon Technology The Sun Tobacco Trainers Training Training Treatment Efficacy United States National Institutes of Health Universities Woman Work base cancer imaging cancer therapy clinical research site cost density design dimethylbenzanthracene engineering design experience experimental study fluorescence imaging follow-up global health image guided imaging capabilities in vivo industry partner instrumentation low and middle-income countries malignant mouth neoplasm medical schools men mortality novel therapeutics oncology oral dysplasia oral lesion physical science portability pre-clinical public health relevance rural area screening tissue phantom treatment response tumor validation studies

展开

项目摘要

DESCRIPTION (provided by applicant): Oral cancer represents over 30% of cancers reported in India, one of the highest oral cancer rates in the world, (attributed to the widespread popularity of chewing "gutka") and is the leading cause of cancer death among Indian men. The overall impact is increased morbidity, mortality and economic burden. This application aims to address the problem of oral cancer by using a low cost adaptation of photodynamic therapy (PDT), an active area of research in our group. The thrust of the study is to design a platform that can be used at sites without medical infrastructure and uses battery-powered light sources and smart phones along with d-aminolevulinic acid, (ALA) as the photodynamic agent. We achieve this in four specific aims executed in two phases: We initially adapt and calibrate current clinical PDT technologies for LMIC use (Aims 1and 2 UH2 phase), then, conduct a validation study at the LMIC site (India) and establish a business plan for long term sustainability of low cost PDT as a global health technology for oral cancer treatment (Aims 3 and 4 UH3 phase).Aim 1 will adapt and calibrate existing PDT treatment and imaging technologies for oral cancers to a low-cost, battery powered format. Aim 2 will optimize LED-based ALA/PpIX PDT and Imaging in pre-clinical hamster models of oral cancer. Aim 3 will validate clinical performance of PDT treatment of oral cancers and dysplasia at LMIC sites. Aim 4 will establish a sustainable long-term business, dissemination and healthcare training plan. The design is made particular to the Indian context by strong collaborative relationships with surgeons and therapists in at the Jawaharlal Nehru Hospital, Aligarh Muslim University (AMU), India, DUSA pharmaceuticals, a subsidiary of Sun Pharmaceuticals (an India-based conglomerate and suppliers of ALA), Physical Sciences Inc. (PSI) an optical instrument design Massachusetts company and physician consultants with extensive experience in the delivery of PDT globally. The UH3 phase will also include a sustainable business plan development and will evaluate the long-term goal of incorporating solar powered batteries (not part of the current application) for which we will reach out for advice to the Dartmouth Humanitarian Engineering (DHE) that has devoted significant resources to studying sustainability issues in emerging economies. This will be facilitated by one of our investigators who is an active alumnus of DHE.

描述（由申请人提供）：口腔癌代表印度报告的癌症的30％以上是世界上口腔癌的最高癌症之一（归因于咀嚼“ Gutka”的广泛普及），是印度男性癌症死亡的主要原因。总体影响是发病率，死亡率和经济负担增加。该应用程序旨在通过使用低成本适应光动力疗法（PDT），这是我们小组中的活跃研究领域。该研究的目的是设计一个可以在没有医疗基础设施的站点上使用的平台，并使用电池供电的光源和智能手机以及D-氨基苯甲酸（ALA）作为光动力剂。我们以两个阶段执行的四个具体目标实现了这一点：我们最初适应了当前的LMIC使用临床PDT技术（目标1和2 UH2阶段），然后在LMIC站点（印度）进行验证研究（印度）（印度），并建立了一项长期可持续性的业务计划，用于对全球卫生疗法的低成本pdt a a a Ad Ad Ad Adt a a Apair 3和4 UH 3 UH 3 UH 3 UH 3 UH 3 UH 3 UH 3阶段。以及口服癌症的成像技术，可达到低成本电池供电的格式。 AIM 2将优化基于LED的ALA/PPIX PDT和临床前口腔癌模型中的成像。 AIM 3将验证在LMIC部位对口服癌症和发育不良的PDT治疗的临床性能。 AIM 4将建立可持续的长期业务，传播和医疗培训计划。与外科医生和治疗师在Jawaharlal Nehru医院，Aligarh穆斯林大学（AMU），印度，DUSA Pharmaceuticals，Sun Pharmaceuticals（ALA的基于ALA和供应商）的物理学设计，PSI的咨询师（PSI），在印度的背景下，特殊的合作关系。全球PDT的交付。 UH3阶段还将包括可持续的商业计划开发，并将评估合并太阳能电池（不是当前应用程序的一部分）的长期目标，我们将为达特茅斯人道主义工程（DHE）提供建议，该工具专门用于研究新兴经济体中可持续性问题的重要资源。我们的一位活跃的DHE校友将促进这一点。