Renovation for Animal Facility Safety & Long-Tern Support of Research at the Univ

动物设施安全改造

• 批准号: 8713008
• 负责人: Craig A Fletcher
• 金额: $ 45.88万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8713008
• 关键词: 20 year old; Accounting; Accreditation; Alcohols; Allergens; Animal Experimentation; Animal Housing; Animal Model; Animals; Area; Arthritis; Bacterial Genes; Beds; Behavioral; Biohazardous Substance; Biological; Biomedical Research; Breeding; Cancer Center; Carcinogens; Caring; Censuses; Chemicals; Communicable Diseases; Communities; Complex; Digestive System Disorders; Disease; Environment; Environmental Health; Environmental air flow; Equipment; Exposure to; Faculty; Funding; Future; Genetic; Genome; Germ-Free; Gnotobiotic; Goals; Grant; Home environment; House mice; Housing; Human Resources; Humidity; Injury; Institution; International; Malignant Neoplasms; Mus; Mutant Strains Mice; Nature; North Carolina; Pharmacy Schools; Physiological; Population; Process; Pulmonary Cystic Fibrosis; Rattus; Research; Research Personnel; Research Support; Resources; Rodent; Rodent Model; Safety; Science; Services; Side; Specific Pathogen Frees; System; Temperature; Tern; United States National Institutes of Health; Universities; Water; Work; animal care; animal facility; chemical allergen; design; ergonomics; exhaust; exposed human population; germ free condition; hazard; human disease; improved; innovation; medical schools; meetings; member; nanomedicine; novel; operation; pathogen; programs; repository; trait

DESCRIPTION: University of North Carolina at Chapel Hill (UNC) cares for approximately 38,000 cages of mice housed in 18 different facilities. UNC is one of 4 Mutant Mouse Regional Resource Centers (MMRRC) and now also houses the Complex Trait Consortium Collaborative Cross (CC) breeding program. These NIH sponsored programs serve as a major repository of mouse stocks and serve the world-wide genetics and biomedical research community identifying novel disease-modifying loci. In addition, UNC is home for the National Gnotobiotic Rodent Resource Center (NGRRC) which provides services on local, national and international levels to academic institutions and governmental programs. The Thurston-Bowles Building (TBB) animal facility houses animals for 24 faculty members from 11 different departments and centers in the School of Medicine including the following Centers: Lineberger Comprehensive Cancer (LCCC), Infectious Diseases, Digestive Diseases, Nanomedicine, Cystic Fibrosis/Pulmonary Research and Treatment, the Bowles Center for Alcohol Studies, Thurston Arthritis Research, Genome Sciences, plus the School of Pharmacy. The TBB animal facility was constructed to house primarily large-animal species. TBB is comprised of 100% specific pathogen free rodent populations. However, while the demand for rodent housing in Thurston has increased, and innovation in animal caging would allow increases in the numbers of cages this building could accommodate, this expansion has not been possible because of limitations imposed by the design of the cage wash area and the current limitations of existing equipment for processing this caging. Funds are sought in this proposal to renovate the cage wash in the Thurston-Bowles animal facility to allow the full potential of this facility to be realized. We wil attain our objective by pursuing the following three specific aims: 1. Replace the rack washers with two energy efficient high throughput cage and rack washers: Two Tecniplast GP 900 cage and utensil washers will be purchased and installed to optimize cleaning of cages and improve efficiency of cage processing significantly which will allow an increase in the number of barrier-housed animals to meet future needs. 2. Optimize and increase the animal space in the dirty side of cage wash: Renovations in the physical configuration of the cage wash area will be made to accommodate higher return cage numbers, increased processing of cages, and processing of cages from animals with experimental pathogens and biohazards under conditions which meet environmental health and safety standards. 3. Improve cage wash safety and modernize the HVAC and exhaust system in the cage wash facility: This will improve environmental conditions, and cage processing efficiency in the washroom, and reduce personnel exposure to injuries, allergens, and animal cage bedding hazards. The proposed renovations to TBB cage wash would support $24,301,730 ongoing, extramurally funded grants and $13,798,653 that are pending.

描述：北卡罗来纳大学教堂山分校 (UNC) 饲养着 18 个不同设施中的约 38,000 个老鼠笼。北卡罗来纳大学是 4 个突变小鼠区域资源中心 (MMRRC) 之一，现在还设有复杂性状联盟协作杂交 (CC) 育种计划。这些由美国国立卫生研究院 (NIH) 赞助的项目作为小鼠种群的主要储存库，为世界范围内的遗传学和生物医学研究界提供服务，以识别新的疾病缓解基因座。此外，北卡罗来纳大学还是国家知生啮齿动物资源中心 (NGRRC) 的所在地，该中心为学术机构和政府项目提供地方、国家和国际层面的服务。瑟斯顿-鲍尔斯大楼 (TBB) 动物设施为来自医学院 11 个不同部门和中心的 24 名教职人员饲养动物，其中包括以下中心：莱恩伯格综合癌症 (LCCC)、传染病、消化系统疾病、纳米医学、囊性纤维化/肺部研究与治疗、鲍尔斯酒精研究中心、瑟斯顿关节炎研究、基因组科学以及药学院。 TBB 动物设施主要用于饲养大型动物。 TBB 由 100% 无特定病原体的啮齿动物种群组成。然而，虽然瑟斯顿对啮齿动物住房的需求有所增加，并且动物笼舍的创新将允许增加该建筑可容纳的笼子数量，但由于笼子清洗区域和笼子清洗区设计的限制，这种扩展是不可能的。目前处理这种笼养的现有设备的局限性。该提案寻求资金来翻新瑟斯顿-鲍尔斯动物设施的笼子清洗装置，以充分发挥该设施的潜力。我们将通过追求以下三个具体目标来实现我们的目标： 1. 用两台节能高通量笼式和架式清洗机替换架式清洗机：将购买并安装两台 Tecniplast GP 900 笼式和器皿清洗机，以优化笼式清洗并改善网箱加工效率显着提高，这将增加屏障饲养动物的数量，以满足未来的需求。 2.优化和增加笼洗脏侧的动物空间：对笼洗区域的物理配置进行改造，以容纳更多的返回笼数，增加笼子的处理量，以及处理带有实验病原体的动物的笼子符合环境健康和安全标准的条件下的生物危害。 3. 提高笼子清洗安全性，并对笼子清洗设施中的 HVAC 和排气系统进行现代化改造：这将改善清洗室的环境条件和笼子处理效率，并减少人员遭受伤害、过敏原和动物笼子垫料危害的机会。 TBB 笼子清洗的拟议翻修将支持 24,301,730 美元的持续外部资助拨款和 13,798,653 美元的待决拨款。