TASK AREA 1: MANUAL OF OPERATIONS

任务领域 1：操作手册

基本信息

批准号：
9365927
负责人：
金额：
$ 0.1万
依托单位：
BROAD INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-26 至 2016-10-25
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9365927
关键词：
Area Behavioral Blood Caring Clinical Clinical Data Clinical Trials Communities Coupling DNA Methylation Data Diagnosis Disease Drug Targeting Electronic Health Record Ensure Environment Environmental Risk Factor Genes Genetic Markers Genetic Transcription Health Heart Image Institutes Lung Manuals Medicine Methylation Molecular Molecular Profiling National Heart, Lung, and Blood Institute Organ Outcome PMI cohort Patients Population Heterogeneity Precision Medicine Initiative Proteomics Research Risk Sample Size Sleep Sleep Disorders System Testing Tissues Trans-Omics for Precision Medicine Translating United States National Institutes of Health base disorder subtype epigenomics genome sequencing improved mHealth metabolomics molecular marker operation personalized intervention precision medicine prevent programs repository whole genome

项目摘要

The NHLBI Trans-Omics for Precision Medicine (TOPMed) program will support the Institute’s larger precision medicine initiative by collecting and coupling whole-genome sequencing (WGS) and other -omics data (e.g., DNA methylation signature, RNA expression profiles, metabolite profiles) with molecular, behavioral, imaging, environmental, and clinical data from studies focused on heart, lung, blood and sleep (HLBS) disorders. The TOPMed program aims to: •Collect and assemble -omics (RNASeq, methylation, metabolomics, epigenomics, and proteomics) data with WGS and clinical outcomes data across diverse populations including those traditionally underrepresented in research. •Build a data commons repository that the scientific community can use for future research and to enable precision medicine. •Stimulate systems medicine approaches that help organize data to ensure they are accessible and interpretable for health disease research. •Promote discoveries about the fundamental mechanisms that underlie HLBS disorders.

NHLBI 精准医学跨组学 (TOPMed) 计划将通过收集和耦合全基因组测序 (WGS) 和其他组学数据（例如 DNA 甲基化特征、RNA 表达谱、代谢物谱）来支持该研究所更大规模的精准医学计划包含来自针对心脏、肺、血液和睡眠 (HLBS) 疾病的研究的分子、行为、成像、环境和临床数据。 TOPMed 计划旨在： •通过WGS 收集和组装组学（RNASeq、甲基化、代谢组学、表观基因组学和蛋白质组学）数据以及不同人群的临床结果数据，包括传统上在研究中代表性不足的人群。 •建立科学界可用于未来研究并实现精准医疗的数据共享存储库。 • 刺激系统医学方法，帮助组织数据，确保它们可用于健康疾病研究并可解释。 •促进HLBS 疾病的基本机制的发现。