Drug Abuse Trajectories in the Transition to Adulthood: Risk Factors and Outcomes

向成年过渡过程中的药物滥用轨迹：风险因素和结果

基本信息

批准号：
8433393
负责人：
AMELIA M ARRIA
金额：
$ 55.77万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-06-01 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8433393
关键词：
Achievement Address Adolescent Adult Affect Age Alcohol consumption Alcohol or Other Drugs use Alcohols Analgesics Anxiety Area Clinical Cocaine DSM-IV Data Data Collection Data Set Decision Making Dependence Deterioration Development Diagnostic Distal Drops Drug Prescriptions Drug abuse Drug usage Drug user Early Intervention Economically Deprived Population Ensure Equation Exhibits Family Family Characteristics Friends Funding Goals Health Health Services Heavy Drinking Illicit Drugs Individual Intervention Interview Investments Joints Knowledge Lead Learning Life Literature Longitudinal Studies Measurement Measures Mediating Medical Mental Depression Mental Health Mental Health Services Mental disorders Modeling National Institute of Drug Abuse Natural History Occupational Opiate Addiction Outcome Parents Pattern Performance Personal Satisfaction Pharmaceutical Preparations Policy Maker Prevalence Prevention Preventive Preventive Intervention Prospective Studies Public Health Publications Publishing Quality of life Research Research Infrastructure Resolution Risk Risk Factors Safety Sampling Schools Sexually Transmitted Diseases Shapes Social support Societies Staging Structure Students Substance Use Disorder System Testing Time United States Universities Work Youth base clinical decision-making cocaine use cohort college drug abuse prevention economic cost follow-up health care delivery health care service utilization high risk high risk sexual behavior high school improved innovation meetings misuse of prescription only drugs nonmedical use peer influence physical conditioning pre-clinical prescription opiate prospective psychosocial response success university student young adult

项目摘要

DESCRIPTION (provided by applicant): An estimated 21 percent of the nation's 7.5 million full-time college students have used an illicit drug in the past month. Moreover, our work over the past three years has documented that concurrent nonmedical prescription drug use, other illicit drug use, and heavy drinking can all potentially affect the health, safety and well-being of college students. Unfortunately, most prior research on college students has focused solely on alcohol; the few studies on college student drug use and associated problems have had limited explanatory power or have not covered a wide scope of risk factors and consequences. Questions regarding the persistence of drug problems, (including substance use disorder) and their sequelae after college remain unanswered. This knowledge gap has severely hampered drug prevention efforts and preventive health care services for young adults. In 2003, our investigative team began an unprecedented NIDA- funded initiative to address this gap-and learn more about the natural history and consequences of illicit drug use among college students. Systematic sampling yielded a cohort of 1253 students for a longitudinal prospective study, of which 95 percent are still active in the study after 3 years of follow-up. In-depth annual interviews have yielded a rich dataset containing a wide array risk factors and outcomes. All students, regardless of academic status, are still being studied. This renewal application builds on our previous findings and proposes to continue our follow-up of this valuable cohort to answer new questions about psychosocial and physical health outcomes as they transition to adulthood. Specifically, it aims to: 1) study the persistence of drug use trajectories, including the resolution of drug problems and development of dependence; 2) understand how college drug use might interfere with achieving developmental milestones such as occupational goals and adaptive social support structures; 3) examine the reciprocal relationships over time of drug use and mental health in relation to physical health (including high-risk sexual behaviors) and quality of life; and, 4) examine potential adverse long-term consequences of cocaine and nonmedical prescription drug use, which have both significantly increased over time in our sample. This renewal offers the field a rare opportunity to probe into new transdisciplinary areas of research, and will use prospective multidimensional modeling that will take advantage of ten years of data to understand their health and functioning in the post-college period. The continuation of this study will maximize the return on NIDA's earlier investment in the project. Ultimately, the results will lead to innovative drug abuse intervention strategies, shape clinical decision-making, and improve health service delivery systems for young adults. Our ambitious and comprehensive approach ensures that this longitudinal prospective study will answer major questions about how to reduce the long-term personal and family turmoil associated with drug abuse, enable young adults to fulfill their individual potential, and reduce unnecessary economic costs to society.

描述（由申请人提供）：据估计，全国 750 万全日制大学生中有 21% 在过去一个月内使用过非法药物。此外，我们过去三年的工作证明，同时使用非医疗处方药、其他非法药物使用和酗酒都可能影响大学生的健康、安全和福祉。不幸的是，之前大多数针对大学生的研究都只关注酒精。关于大学生吸毒及相关问题的少数研究解释力有限，或者没有涵盖广泛的风险因素和后果。关于药物问题（包括物质使用障碍）的持续存在及其大学毕业后的后遗症的问题仍未得到解答。这种知识差距严重阻碍了青少年的毒品预防工作和预防性保健服务。 2003 年，我们的调查团队开始了一项由 NIDA 资助的史无前例的举措，以解决这一差距，并更多地了解大学生非法药物使用的自然历史和后果。系统抽样对 1253 名学生进行了纵向前瞻性研究，其中 95% 的学生在 3 年随访后仍然活跃在该研究中。深入的年度访谈产生了包含广泛风险因素和结果的丰富数据集。所有学生，无论学业状况如何，都仍在接受研究。此更新应用程序建立在我们之前的研究结果的基础上，并建议继续对这一有价值的群体进行跟踪，以回答有关他们过渡到成年后的心理社会和身体健康结果的新问题。具体而言，其目的是：1）研究吸毒轨迹的持续性，包括吸毒问题的解决和依赖性的发展； 2）了解大学吸毒可能如何干扰实现职业目标和适应性社会支持结构等发展里程碑； 3) 检查一段时间内吸毒和心理健康与身体健康（包括高危性行为）和生活质量之间的相互关系； 4）检查可卡因和非医疗处方药使用的潜在不利长期后果，在我们的样本中，这两种药物随着时间的推移都显着增加。此次更新为该领域提供了一个难得的机会来探索新的跨学科研究领域，并将使用前瞻性多维模型，利用十年的数据来了解他们在大学毕业后的健康和功能。这项研究的继续进行将最大限度地提高 NIDA 早期对该项目的投资回报。最终，研究结果将带来创新的药物滥用干预策略，影响临床决策，并改善年轻人的卫生服务提供系统。我们雄心勃勃且全面的方法确保这项纵向前瞻性研究将回答有关如何减少与药物滥用相关的长期个人和家庭动荡、使年轻人发挥个人潜力并减少社会不必要的经济成本的主要问题。

项目成果

期刊论文数量（76）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Perceived harmfulness predicts nonmedical use of prescription drugs among college students: interactions with sensation-seeking.

感知危害预测大学生处方药的非医疗使用：与感觉寻求的相互作用。

DOI：
发表时间：
2008-09
期刊：
影响因子：
0
作者：
Arria, Amelia M;Caldeira, Kimberly M;Vincent, Kathryn B;O'Grady, Kevin E;Wish, Eric D
通讯作者：
Wish, Eric D

Nonmedical prescription analgesic use and concurrent alcohol consumption among college students.

大学生非药物处方镇痛使用和同时饮酒。

DOI：
发表时间：
2009
期刊：
影响因子：
0
作者：
Garnier, Laura M;Arria, Amelia M;Caldeira, Kimberly M;Vincent, Kathryn B;O'Grady, Kevin E;Wish, Eric D
通讯作者：
Wish, Eric D

Prevalence and predictors of persistent suicide ideation, plans, and attempts during college.

大学期间持续自杀意念、计划和尝试的患病率和预测因素。

DOI：
发表时间：
2010-12
期刊：
影响因子：
6.6
作者：
Wilcox, Holly C;Arria, Amelia M;Caldeira, Kimberly M;Vincent, Kathryn B;Pinchevsky, Gillian M;O'Grady, Kevin E
通讯作者：
O'Grady, Kevin E

Persistent nonmedical use of prescription stimulants among college students: possible association with ADHD symptoms.

大学生持续非医疗使用处方兴奋剂：可能与多动症症状相关。