Mali ICEMR- Data Management and Biostatistics Core

马里 ICEMR-数据管理和生物统计核心

• 批准号: 9263340
• 负责人: Mahamoudou Toure
• 金额: $ 9.55万
• 依托单位: UNIV OF SCIENCES, TECH & TECH OF BAMAKO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9263340
• 关键词: Africa; Africa South of the Sahara; Artemisinins; Beds; Behavior; Biometry; Biostatistics Core; Case Management; Cessation of life; Chemoprevention; Child; Clinical Data; Clinical Research; Collaborations; Combined Modality Therapy; Country; Data; Data Analyses; Data Base Management; Data Collection; Data Quality; Data Security; Data Storage and Retrieval; Development; Disease; Disease Outcome; Drug resistance; Ecology; Effectiveness; Environment; Genetic Vectors; Genotype; Goals; Human; Immune response; Incidence; Infection; Insecticides; Interdisciplinary Study; Intervention; Malaria; Mali; Monitor; Outcome; Parasites; Pharmacotherapy; Pregnant Women; Prevention; Procedures; Process; Protocols documentation; Reporting; Research; Research Personnel; Residual state; Sahara; Snow; System; Training; United States National Institutes of Health; Universities; Update; base; behavioral response; data management; design; meetings; quality assurance; response; scale up; tool; vector mosquito

CORE B – SUMMARY Wide deployment of malaria control tools in the past decade has significantly contributed to substantial reduction of the incidence and deaths related to the disease in Sub-Sahara Africa. Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. The Overall goal of this ICEMR is to understand the variable effectiveness of current malaria control interventions in different ecological settings of West Africa through research to understand interactions between the parasite (response to drug treatment, genotypes, gametocyte survival), human (immune response and host genetics) and the vector (ecology, behaviors, and response to insecticides) and regulating influences of the local environment and human behavior. The goal of the Data Management and Biostatistics (DMB) Core is to provide data management and biostatistical support to the ICEMR investigators of Mali in order to produce reliable and high quality research data and data analysis. The specific aims of DMB are: 1]To set up a data management system office meeting all standards of confidentiality, reporting, data quality, and data security to support, in collaboration with the ICEMR investigators, 2] To support ICEMR investigators in study planning, study conduct and data management activities including: project management, data collection, data entry, study quality assurance, data storage, and retrieval, and updating standard operating procedures, and in database management and processes; 3] Support ICEMR investigators in protocol designing and development, in monitoring of studies, and in both interim and final data analyses; 4] To provide required training in clinical research and data analysis for investigators and technicians to meet all standards. The Core B will be based at the NIH-University of Bamako Center of Excellence in Research, Mali.

核心 B – 总结 过去十年来，疟疾控制工具的广泛部署为疟疾防治工作做出了重大贡献 撒哈拉以南非洲地区与该疾病相关的发病率和死亡人数仍在减少。 在全球疟疾死亡负担中所占比例过高。 在某些情况下仍处于高位但稳定，而在其他情况下则在长期相关下降后反弹 密集部署疟疾控制工具 ICEMR 的总体目标是了解该变量。 当前西非不同生态环境中疟疾控制干预措施的有效性 研究了解寄生虫之间的相互作用（对药物治疗、基因型、配子体的反应） 生存）、人类（免疫反应和宿主遗传学）和载体（生态、行为和对环境的反应） 杀虫剂）以及调节当地环境和人类行为的影响。 管理和生物统计（DMB）核心是为数据管理和生物统计提供支持 马里的 ICEMR 调查人员旨在提供可靠且高质量的研究数据和数据分析。 DMB的具体目标是： 1]建立一个满足所有标准的数据管理系统办公室 与 ICEMR 合作，在保密性、报告、数据质量和数据安全方面提供支持 研究者，2] 支持 ICEMR 研究者进行研究规划、研究实施和数据管理 活动包括：项目管理、数据收集、数据输入、研究质量保证、数据存储和 检索和更新标准操作程序，以及数据库管理和流程；3] 支持 ICEMR 研究人员进行方案设计和开发、研究监测以及这两个方面 中期和最终数据分析； 4] 为临床研究和数据分析提供所需的培训； 满足所有标准的研究人员和技术人员将设在 NIH 巴马科大学。 马里卓越研究中心。