MBSR for fibromyalgia: A dose-finding study

MBSR 治疗纤维肌痛：剂量探索研究

• 批准号: 8636997
• 负责人: Ather Ali
• 金额: $ 13.42万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8636997
• 关键词: Abdominal Pain; Adherence; Adolescent; Adult; Advisory Committees; Affect; Child; Childhood; Clinical; Data; Data Quality; Development; Development Plans; Diagnosis; Diagnostic; Disabled Persons; Dose; Ensure; Evaluation Studies; Fibromyalgia; Future; Goals; Grant; Headache; Individual; Institution; Integrative Medicine; Intervention; Intervention Studies; Mentors; Mind-Body Intervention; Outcome; Pain; Participant; Patients; Physical Function; Population; Protocols documentation; Research; Research Personnel; Research Training; Safety; Strategic Planning; Testing; Time; Universities; Waiting Lists; abstracting; career development; chronic pain; chronic widespread pain; clinical care; experience; improved; insight; meetings; mindfulness; mindfulness meditation; public health relevance; randomized trial; research clinical testing; skills; success

Grant: K23 AT006703 PI: Ather Ali, ND, MPH Institution: Yale University Modified Title: Mindfulness Interventions and Chronic Widespread Pain in Adolescents Modified Project Summary/Abstract Section There is increasing evidence that many chronic pain conditions that affect large numbers of adults (e.g. headaches, functional abdominal pain, fibromyalgia) begin in childhood and persist. Recent data show that a large proportion of individuals diagnosed with juvenile fibromyalgia/chronic widespread pain continued to meet diagnostic criteria for fibromyalgia into adulthood. These patients often became increasingly disabled over time. There is a great need for safe, effective, and well-tolerated interventions for younger populations. A number of trials have assessed various forms of mindfulness meditation with promising results in outcomes in adults ranging from reduced pain, improved physical function, and fewer tender points in adults with fibromyalgia. However, there have been no studies in children and the success in adults is tempered by the challenge in tailoring mindfulness interventions for pediatric populations in which issues of adherence, feasibility, parental support, and developmental appropriateness need to be incorporated into the protocol. The focus of the K23 research is to develop and test the feasibility, safety, tolerability and acceptability of a mindfulness meditation intervention for adolescents with juvenile fibromyalgia/widespread chronic pain. This study will provide high-quality data for a larger, more definitive R01 submission. The goals of this project are consistent with NCCAM's emphasis on treating chronic pain and Strategic Plan goals to “support clinical evaluation and intervention studies of mind/body interventions” and “support high-quality research training and career development opportunities to increase the number, quality, and diversity of CAM researchers.” In addition to the research, the candidate will regularly meet with his mentor and advisory committee to ensure consistent progress and adherence to the training, research, and career development plan. This will help ensure a productive period of career development, and provide the skills, experience, and guidance in order to advance to an independent clinician-researcher focused on chronic pain and integrative medicine interventions.

补助金：K23 AT006703 PI：Ather Ali，ND，MPH 院校：耶鲁大学 修改后的标题：正念干预和青少年慢性广泛疼痛 修改后的项目摘要/摘要部分 越来越多的证据表明，影响大量成年人的许多慢性疼痛（例如头痛、功能性腹痛、纤维肌痛）始于儿童期并持续存在。最近的数据显示，很大一部分被诊断患有青少年纤维肌痛/慢性广泛性疼痛的人仍然患有这种疾病。随着时间的推移，这些患者往往变得越来越残疾，因此非常需要针对年轻人群的安全、有效和耐受性良好的干预措施。 许多试验评估了各种形式的正念冥想，在成人中取得了良好的效果，包括减轻疼痛、改善身体功能和减少成人纤维肌痛的压痛点，但目前还没有在儿童中进行的研究以及在成人中取得的成功。为儿科人群量身定制正念干预措施面临着挑战，其中需要将依从性、可行性、父母支持和发育适宜性问题纳入协议中。 K23 研究的重点是开发和测试针对患有青少年纤维肌痛/广泛慢性疼痛的青少年的正念冥想干预的可行性、安全性、耐受性和可接受性。这项研究将为更大、更明确的 R01 提交提供高质量的数据。该项目的目标与 NCCAM 对治疗慢性疼痛的重视和战略计划目标一致，即“支持身心干预的临床评估和干预研究”和“支持高质量的研究培训和职业发展机会，以增加CAM 研究人员的数量、质量和多样性。” 除了研究之外，候选人还将定期与他的导师和咨询委员会会面，以确保持续进步并遵守培训、研究和职业发展计划，这将有助于确保职业发展的富有成效的时期，并提供技能、经验和指导，以晋升为专注于慢性疼痛和综合医学干预的独立临床医生研究员。