Deciphering the role of Notch signaling in zebrafish heart regeneration

破译Notch信号在斑马鱼心脏再生中的作用

• 批准号: 9041018
• 负责人: CAROLINE E BURNS
• 金额: $ 43.5万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9041018
• 关键词: Adult; Cardiac; Cardiac Myocytes; Cell Cycle Arrest; Cell physiology; ChIP-seq; Chromatin; Clinical; Collaborations; Complement; DNA Damage; Data; Data Set; Endocardium; Epicardium; Epigenetic Process; Epithelium; Excision; Exhibits; Fibrosis; Fishes; Gene Expression; Genes; Goals; Health; Heart; Heart failure; Histones; Human; Injury; Laboratories; Learning; Mitogens; Modeling; Molecular Profiling; Myocardial; Myocardial Infarction; Myocardium; Natural regeneration; Notch Signaling Pathway; Outcome; Paracrine Communication; Pathway interactions; Patient-Focused Outcomes; Phenotype; Production; Publishing; Reporting; Resolution; Role; Sequence Analysis; Signal Transduction; Testing; Therapeutic; Tissues; Transcriptional Activation; Transgenic Organisms; Vertebrates; Zebrafish; base; cardiac regeneration; demethylation; design; experience; gain of function; genome-wide; improved; injured; innovation; insight; loss of function; new growth; notch protein; novel; novel strategies; novel therapeutic intervention; novel therapeutics; paracrine; prevent; promoter; regenerative; repaired; response to injury; tool

 DESCRIPTION (provided by applicant): Novel therapeutic strategies for stimulating regeneration of human heart muscle would significantly improve clinical outcomes for patients experiencing a heart attack. In contrast to humans, adult zebrafish naturally regenerate their heart muscle following injury. Our lab recently discovered that the Notch signaling pathway becomes activated following cardiac injury in zebrafish and is required for stimulating growth of new cardiac muscle. The goal of this application is to gain new mechanistic insight into how Notch stimulates heart regeneration in fish with the long-term goal of informing new therapeutic strategies for redirecting or repurposing activated Notch for clinical benefit in humans.

 描述（由适用提供）：刺激人心肌再生的新型治疗策略将显着改善患有心脏病发作的患者的临床结果。与人类相反，成年斑马鱼自然会在受伤后再生其心肌。我们的实验室最近发现，斑马鱼心脏损伤后，Notch信号通路被激活，这是刺激新心肌生长所必需的。该应用的目的是获得新的机械洞察力，以了解Notch如何刺激鱼类的心脏再生，其长期目标是为新的治疗策略提供了新的治疗策略，以重定向或重新利用激活的置于人类的临床益处。