Novel Research Findings on Environmental Asbestos Exposure

关于环境石棉暴露的新研究结果

• 批准号: 9195387
• 负责人: Deborah E. Keil
• 金额: $ 1.8万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9195387
• 关键词: Academia; Address; Amphiboles; Area; Asbestos; Autoantibodies; Biological Markers; Carcinoma; Characteristics; Childhood; Communities; Confusion; Consensus; Data; Deposition; Development; Disease; District of Columbia; Educational workshop; Epidemiologic Studies; Exposure to; Fiber; Fibrosis; Fire - disasters; Funding; Future; Geology; Goals; Health; Health Personnel; Investigation; Lung; Lung diseases; Malignant Neoplasms; Meleagris gallopavo; Mesothelial Cell; Mesothelioma; Mineral Fibers; Minerals; Mining; Montana; National Institute for Occupational Safety and Health; Nevada; Nomenclature; Occupational; Occupational Exposure; Occupations; Outcome; Participant; Pathogenicity; Patients; Pennsylvania; Pleural; Pleural Diseases; Public Health; Research; Research Personnel; Risk; Risk Assessment; Science; Superfund; Terminology; Thinking; Toxic effect; Universities; Work; base; erionite; follow-up; hazard; improved; meetings; news; novel; particle; programs; pulmonary function decline; symposium; vermiculite

ABSTRACT There is a paradigm shift occurring in asbestos research that is forcing experts in several fields to reconsider the current nomenclature and our understanding of health effects of different types of mineral fibers. There is a critical need to bring these experts together to consider these challenges to the traditional ways of studying asbestos, to discuss the emerging needs, and to adapt our research approaches. The proposed conference addresses that critical need by coordinating with the National Institute for Occupational Safety and Health. Issues making this meeting timely include, a) discoveries of Naturally Occurring Asbestos (NOA) in bedrock and alluvial deposits in several states in the U.S., as well as around the world, with a footprint much larger than previously estimated, b) recent data showing that mineral fibers that do not meet the strict regulatory definition of “asbestos” nevertheless have health consequences, c) novel findings from ATSDR-funded Libby Epidemiology Research Program (LERP) and Childhood Health Exposure Follow-up Investigation Study (CHIEFS) which mandate a new look at non-cancer asbestos related disease, in addition to the traditional use of cancer as the health end point most often used to determine asbestos toxicity, d) the new reference concentration (RfC) for Libby Amphibole which has been established by the EPA based on data showing non-cancer outcomes at very low exposures. The new RfC may impact future risk assessment as new NOA exposures occur. The conference proposed in this application will be held in conjunction with a NIOSH-sponsored meeting regarding nomenclature and characterization of asbestos fibers, giving us the perfect opportunity to establish an interdisciplinary discussion regarding the characteristics of asbestos that cause disease. The overall combined conference will take place in September 2016, at Lister Hill Auditorium in Washington, DC. The working title for the 1.5- day NIOSH workshop is, “Elongate Mineral Fiber Terminology and Characterization”. The health effects portion of the conference (this application) will also be 1.5 days, and will be titled, “Novel Research Findings on Environmental Asbestos Exposure”. Our aims are to: a) bring together national experts in fiber pathogenicity, recent health outcomes discoveries, and risk assessment to share the current state of the science with a broad, combined audience from academia, federal agencies, and the public, and b) initiate discussions that will place priorities on how we can study emerging health risks efficiently, expediently, and with the shared overall goal of protecting public health.

抽象的 石棉研究中发生了一个范式转变，迫使多个领域的专家到 重新考虑当前的命名法和我们对不同类型矿物质的健康影响的理解 纤维。迫切需要将这些专家聚集在一起，以将这些挑战视为传统 研究石棉，讨论新兴需求并适应我们的研究方法。 拟议的会议讲话，以与国家研究所协调进行至关重要的需求 职业安全与健康。使这次会议及时的问题包括，a）自然发现 在美国几个州以及周围发生的基岩和冲积矿床中发生石棉（NOA） 世界，占地面积比以前估计的大得多，b）最近的数据表明矿物纤维 尽管如此，它不符合“石棉”严格的监管定义，但仍具有健康后果，c） 来自ATSDR资助的Libby流行病学研究计划（LERP）和儿童健康的新发现 暴露后续调查研究（酋长）要求对非癌症石棉进行新的外观 相关疾病，除了传统使用癌症作为健康终点外，最常用于 确定石棉毒性，d）Libby闪比尔的新参考浓度（RFC） 由EPA建立的基于数据以非常低的暴露率显示非癌症结果。新的RFC 随着新的NOA暴露发生，可能会影响未来的风险评估。会议提出了 申请将与NIOSH赞助的有关命名法和 石棉纤维的特征，为我们提供了建立跨学科的绝佳机会 关于引起疾病的石棉特征的讨论。整体联合会议 将于2016年9月在华盛顿特区的Lister Hill礼堂举行。 1.5-的工作标题 Day Niosh研讨会是“细长的矿物纤维术语和特征”。健康 会议的效果部分（此应用程序）也将是1.5天，并将标题为“新研究 关于环境石棉暴露的发现”。我们的目的是：a）将国家专家汇集在一起 纤维致病性，最近的健康结果发现和风险评估，以共享目前的状态 来自学术界，联邦机构和公众的广泛，联合观众的科学以及B） 发起讨论将对我们如何有效研究新出现的健康风险的优先事项， 方便，并具有保护公共卫生的共同总体目标。