HSPH-NIEHS Center for Environmental Health

HSPH-NIEHS 环境健康中心

• 批准号: 9351621
• 负责人: Douglas W Dockery
• 金额: $ 3.9万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9351621
• 关键词: Address; Animal Model; Animals; Area; Cell Culture Techniques; Clinical Research; Collaborations; Communication; Communities; Community Health Education; Community Outreach; Data; Discipline; Ensure; Environmental Exposure; Environmental Health; Epidemiology; Family; Future; Goals; Growth; Health; Health Policy; Health Sciences; Home environment; Human; Individual; Institution; Interdisciplinary Study; Investigation; Laboratory Study; Leadership; Metal exposure; Methods; Modeling; National Institute of Environmental Health Sciences; Neighborhoods; Organic Chemicals; Outcome; Particulate; Pathway interactions; Pilot Projects; Population; Productivity; Public Health; Public Policy; Research; Research Personnel; Research Priority; Resources; Risk; Technology; Toxicology; Training; Translating; Universities; academic program; clinical practice; gene environment interaction; human subject; improved; in vitro Model; laboratory facility; multidisciplinary; next generation; patient population; population based; public health relevance; symposium; tool; working group

DESCRIPTION (provided by applicant) The theme begins with a unique and defining strength of the Harvard-NIEHS Center for Environmental Health, the investigators' unmatched portfolio of population and patient studies of environmental exposures and their health effects. These studies of the real-world environmental exposures of human subjects ensure that Center research readily translates into public health policy and clinical practice. These population-based investigations combine with mechanistic laboratory studies to illuminate the pathways by which environmental exposures cause health effects. The Center makes this partnership a productive "two-way street": Data from populations inform and guide studies of pathways in animal and cell culture models. In turn, the evidence from pathway studies is used to improve or develop new population studies of exposures and health effects. Together their "Populations to Pathways" research provides both estimates of human population risk as well as adding to the understanding of mechanistic pathways of environmental health effects. The investigations of populations and pathways in turn inform public health policy and clinical practice. To facilitate interactions the Center is organized around three Research Cores representing major cross-cutting environmental health exposures: Metals, Organic Chemicals, and Particulates. Each of the Research Cores has track record of productivity, potential for continued growth, and the ability to integrate and catalyze leadership in the future. Each Research Core is multidisciplinary and deploys the full range of our intellectual resources. These Research Cores have been highly effective in promoting integration and collaborations through seminars and symposium, invited speakers, working groups, and pilot projects. Each of the three Research Cores features toxicology, basic mechanisms, in vitro models, animal models, gene- environment interactions, epidemiology, risk analysis, risk communication and connects to the Community Outreach and Education Core. Each includes exposure assessment as well as health outcomes in both animal models and human populations. Moreover, each represents an area of considerable activity and accomplishment as well as a compelling list of unsolved concerns. By using the Center mechanism to increase integration, each Research Core is composed of individuals not only from a variety of disciplines, but also from a range of academic programs and departments throughout Harvard and at neighboring institutions. The Community Outreach and Education Core (COEC) provides a community context for the research and integrated health sciences occurring within the Center and supports the Center's goal to translate its research into public health policy and clinical practice, and serves as a conduit for the community and stakeholders to interact with and provide guidance to the Center in defining research priorities and opportunities.

描述（由申请人提供） 该主题始于哈佛-NIEHS 环境健康中心的独特且决定性的优势，以及研究人员对环境暴露及其健康影响进行的人口和患者研究的无与伦比的组合。这些对人类受试者现实世界环境暴露的研究确保中心研究很容易转化为公共卫生政策和临床实践。这些基于人群的调查与机械实验室研究相结合，阐明了环境暴露导致健康影响的途径。该中心使这种伙伴关系成为一条富有成效的“双向街道”：来自人群的数据为动物和细胞培养模型中的途径研究提供信息和指导。 反过来，途径研究的证据用于改进或开发新的暴露和健康影响的人群研究。他们的“人口到途径”研究提供了对人口风险的估计，并增加了对环境健康影响的机制途径的理解。对人群和途径的调查反过来又为公共卫生政策和临床实践提供信息。 为了促进互动，该中心围绕代表主要交叉环境健康暴露的三个研究核心进行组织：金属、有机化学品和颗粒物。 每个研究核心都拥有生产力、持续增长潜力以及整合和促进未来领导力的能力记录。每个研究核心都是多学科的，并部署了我们全方位的智力资源。这些研究核心通过研讨会和专题讨论会、特邀演讲者、工作组和试点项目，在促进一体化和合作方面非常有效。三个研究核心均以毒理学、基本机制、体外模型、动物模型、基因-环境相互作用、流行病学、风险分析、风险沟通为特色，并与社区外展和教育核心相连。 每一项都包括暴露评估以及动物模型和人群的健康结果。此外，每个领域都代表着一个具有大量活动和成就的领域，以及一系列令人信服的未解决问题。通过利用中心机制来加强整合，每个研究核心不仅由来自不同学科的个人组成，而且还由来自哈佛大学和邻近机构的一系列学术项目和部门的个人组成。 社区外展和教育核心 (COEC) 为中心内发生的研究和综合健康科学提供了社区环境，支持中心将其研究转化为公共卫生政策和临床实践的目标，并作为社区和社区的渠道。利益相关者与中心互动并为确定研究重点和机会提供指导。