Sleep Physiology and Risk for Alcohol Problems in Children of Alcoholics

酗酒者儿童的睡眠生理学和酒精问题风险

• 批准号: 9121359
• 负责人: Maria M. Wong
• 金额: $ 22.86万
• 依托单位: IDAHO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9121359
• 关键词: 12 year old; 13 year old; 14 year old; Adolescence; Adolescent; Adopted; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Architecture; Area; Biological; Child; Data; Development; Drug usage; Early Intervention; Epidemiology; Family history of; Funding; Gender; Habits; Health; Human; Individual; Investigation; Lead; Longevity; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; National Institute on Alcohol Abuse and Alcoholism; Nature; Neurocognitive; Parents; Participant; Patient Self-Report; Pattern; Physiology; Polysomnography; Prevention; Preventive Intervention; Problem behavior; Regulation; Research; Research Project Grants; Risk; Risk Marker; Rural Population; Sleep; Sleep Disorders; Sleep disturbances; Stress; Time; Writing; actigraphy; age group; alcohol and other drug; alcohol related problem; alcohol research; alcohol use disorder; children of alcoholics; drinking; drinking onset; early alcohol use; early drinking; early onset; longitudinal design; peer; response; underage drinking; young adult; 12 year old; 13 year old; 14 year old; Adolescence; Adolescent; Adopted; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Architecture; Area; Biological; Child; Data; Development; Drug usage; Early Intervention; Epidemiology; Family history of; Funding; Gender; Habits; Health; Human; Individual; Investigation; Lead; Longevity; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; National Institute on Alcohol Abuse and Alcoholism; Nature; Neurocognitive; Parents; Participant; Patient Self-Report; Pattern; Physiology; Polysomnography; Prevention; Preventive Intervention; Problem behavior; Regulation; Research; Research Project Grants; Risk; Risk Marker; Rural Population; Sleep; Sleep Disorders; Sleep disturbances; Stress; Time; Writing; actigraphy; age group; alcohol and other drug; alcohol related problem; alcohol research; alcohol use disorder; children of alcoholics; drinking; drinking onset; early alcohol use; early drinking; early onset; longitudinal design; peer; response; underage drinking; young adult

DESCRIPTION (provided by applicant): This proposed project is a resubmission of the PI's first R01 application. Alcohol-dependent individuals have well-described disturbances of sleep, but whether these sleep disturbances precede or follow heavy, problem drinking is unknown. Several lines of evidence across the human life span now suggest that sleep disturbances may precede and represent a marker of risk for the development of alcohol use disorders. For instance, there appears to be a longitudinal relationship between sleep problems, alcohol use, and alcohol use disorders in both adolescents and adults. Very few studies, however, have systematically examined the sleep patterns, habits, and architecture of biological children of an alcohol- dependent parent (COAs), who already are at increased risk both to drink earlier than their peers and to have an early onset of alcohol use disorders. A longitudinal investigation of sleep parameters in relation to risk for early onset of alcohol use and alcohol related problems among COAs and controls (non-COAs) would clarify the influence of sleep disturbances and potentially inform prevention and early intervention efforts. The current proposal seeks funding to support a longitudinal study on sleep patterns, architecture, and regulation in COAs and controls. Specific aims are: (i) to examine the sleep patterns, habits, and architecture of COAs and controls over time via multiple measures of sleep, including self-report, parental ratings, actigraphy, and polysomnography; (ii) to understand the effects of sleep disturbances on neurocognitive functions, behavioral problems, and risk for early alcohol use/abuse among COAs and controls; and (iii) to understand how gender, pubertal development, and perceived stress may moderate the relationship between sleep problems and alcohol use/abuse among COAs and controls. A three-wave longitudinal design is proposed. Participants will be 8-12 years old at Time 1, 9-13 years old at Time 2, and 10-14 years old at Time 3. Multiple measures of sleep, including actigraphy and polysomnography data will be collected at Time 1. At Times 2 and 3, actigraphy will be repeated and data on self-report and parental ratings of sleep, as well as neurocognitive functions and behavioral problems will be gathered. Information regarding onset of alcohol and other drug use, as well as related problems will also be collected at Times 2 and 3. This project has the potential to document the relationships among sleep problems, family history of alcoholism, neurocognitive functions, behavioral problems, and the development of alcohol problems among COAs and controls. Results of the study will lead to practical information on the relationship between sleep problems and alcohol use disorders, with implications for prevention and early intervention.

描述（由申请人提供）：该提议的项目是对PI的第一个R01申请的重新提交。依赖酒精的人有很好的睡眠障碍，但是无论这些睡眠障碍还是在沉重的情况下，饮酒尚不清楚。现在，整个人类生命范围内的几条证据表明，睡眠障碍可能是在饮酒障碍发展的风险之前的标志。例如，在青少年和成年人中，睡眠问题，饮酒和饮酒障碍之间似乎存在纵向关系。然而，很少有研究系统地检查了依赖酒精的父母（COA）的亲生子女的睡眠方式，习惯和建筑，他们已经比同龄人早点喝酒的风险增加，并且早期发作酒精使用障碍。对睡眠参数的纵向研究与COAS和COAS（非COAS）之间早期饮酒和与酒精有关的问题的风险有关，这将阐明睡眠障碍的影响，并有可能为预防和早期干预工作提供信息。当前的提案寻求资金支持COA和控制中的睡眠模式，建筑和调节的纵向研究。具体目的是：（i）通过多种睡眠度量，包括自我报告，父母评分，行为语义和多个多摄影术，检查COA和控制的睡眠模式，习惯和结构； （ii）了解睡眠障碍对神经认知功能，行为问题以及COA和控制中早期饮酒/滥用的风险的影响； （iii）了解性别，青春期发展和感知的压力如何减轻睡眠问题与COA和控制之间的酒精使用/滥用之间的关系。提出了三波纵向设计。参与者将在时间1、9-13岁和10-14岁的时间3中年满8-12岁。有关酒精和其他药物使用以及相关问题的信息也将在第2和3时收集。该项目有可能记录睡眠问题之间的关系，酒精中毒家族史，神经认知功能，行为问题以及COAS和控制之间酒精问题的发展。该研究的结果将导致有关睡眠问题与酒精使用障碍之间关系的实际信息，这对预防和早期干预产生了影响。