DATA COORDINATING CENTER - FASST

数据协调中心 - FASST

• 批准号: 9460280
• 负责人: TRACI E CLEMONS
• 金额: $ 30.29万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-06 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9460280
• 关键词: Clinical; Couples; DNA; DNA Fragmentation; Data Collection; Data Coordinating Center; Diet; Embryo; Enrollment; Fertilization; Fertilization in Vitro; Folic Acid; Goals; Human Chorionic Gonadotropin; Incidence; Intervention; Intracytoplasmic Sperm Injections; Morphology; Placebos; Pregnancy; Procedures; Public Health; Recruitment Activity; Reproductive Health; Research; Seminal fluid; Supplementation; System; Treatment outcome; Zinc Sulfate; Zinc supplementation; cell motility; folic acid supplementation; implantation; improved; infertility treatment; men; sperm cell

The overarching goal of this trial is to determine if an intervention comprising dietary folate and zinc supplementation improves semen quality and infertility treatment outcomes among couples undergoing infertility treatment. If efficacious and safe, such an intervention would have considerable public health impact and afford clinicians a simple and inexpensive treatment option for men with suboptimal semen quality. The following study objective underlie successful attainment of the overarching research goal. . To estimate the effect of folic acid and zinc sulfate supplementation on semen quality parameters, including but not limited to concentration, motility, morphology, and sperm DNA fragmentation relative to the placebo group. Recruit, enroll and retain approximately 800 couples for 15 months. Data collection, maintain biospecimen tracking system, for Folic Acid and Zinc supplement trial, in relation to reproductive health. NOTE: Supports Z1AHD008943 915088

该试验的总体目的是确定包括饮食叶酸和补充锌的干预措施是否可以改善接受不育治疗的夫妇的精液质量和不育治疗结果。如果有效且安全，这种干预将对具有次优精液质量的男性的简单且廉价的治疗选择产生可观的公共卫生影响，并为临床医生提供一种简单且廉价的治疗选择。以下研究目标是成功实现总体研究目标的基础。 。为了估计叶酸和硫酸锌补充对精液质量参数的影响，包括但不限于相对于安慰剂组的浓度，运动，形态和精子DNA片段化。招募，注册和保留大约800对夫妇，共15个月。与生殖健康有关的数据收集，维护叶酸和锌补充试验的生物循环跟踪系统。注意：支持Z1AHD008943 915088