Ultrasonic characterization of atherosclerotic plaque using multiple scattering

使用多重散射对动脉粥样硬化斑块进行超声表征

• 批准号: 9360111
• 负责人: Marie Muller
• 金额: $ 6.87万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9360111
• 关键词: Acoustics; Acute myocardial infarction; Angiography; Anisotropy; Architecture; Arterial Fatty Streak; Atherosclerosis; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Catheters; Clinical; Complex; Contrast Media; Coronary artery; Country; Detection; Diagnosis; Diffusion; Dimensions; Event; Family suidae; Frequencies; Future; Image; Imagery; In Vitro; Injectable; Measurable; Measures; Methods; Microbubbles; Monitor; Morbidity - disease rate; Morphology; Patient risk; Property; Research; Research Project Grants; Risk; Rupture; Signal Transduction; Specificity; Structure; Techniques; Testing; Thrombosis; Time; Travel; Ultrasonic wave; Ultrasonics; Ultrasonography; X-Ray Computed Tomography; angiogenesis; base; contrast enhanced; density; imaging approach; imaging modality; improved; in vivo; mortality; neovascular; neovascularization; novel; novel strategies; quantitative ultrasound; screening; sudden cardiac death; tool; vasa vasorum

ABSTRACT Atherosclerosis is the leading cause of morbidity and mortality in Western countries, in large part due to plaque rupture. Vulnerable plaques are the most likely to rupture, being the major cause of acute myocardial infarction and sudden cardiac death. Neovascularization of the arterial walls by adventitial vasa vasorum appears to participate in the progression of atherosclerosis and atherosclerotic plaque neovascularization was shown to be one of the strongest predictors of future cardiovascular events. No techniques are currently available for the quantitative assessment of vulnerable plaque, which remains an unmet need. Microbubbles are extremely powerful contrast agents for ultrasonic imaging of the vasculature and Contrast Enhanced IntraVascular UltraSound (CE-IVUS) seems to be one of the most promising imaging modalities for the detection of atherosclerosis and vulnerable plaque. However, although this technique allows the detection of the vasa vasorum, CE-IVUS currently does not provide a quantitative characterization of its micro-architecture. The specificity of CE- IVUS needs to be improved. A quantitative assessment of the vasa vasorum network in vivo would strongly predict cardiovascular events yet no such techniques currently exist. We propose using ultrasound multiple scattering to characterize the microstructural properties of neovascular networks. By using ultrasound multiple scattering to characterize the architecture of the neovascularization, we will add a new dimension to CE-IVUS. With the technique we propose to develop here, CE-IVUS will not only be used for the detection of plaque related neo-angiogenesis, but also for its quantitative characterization. This will dramatically increase the specificity of CE-IVUS for the assessment of plaque vulnerability. Ultimately, it will enable the ultrasonic assessment of the vasa vasorum to become a widely used clinical tool for screening, diagnosis and monitoring of plaque vulnerability.

抽象的 动脉粥样硬化是西方国家发病和死亡率的主要原因， 大部分是由于斑块破裂。易受伤害的斑块是最有可能破裂的，是主要的 急性心肌梗塞和心脏突然死亡的原因。动脉新血管 外在Vasa vasorum的墙似乎参与了动脉粥样硬化和 动脉粥样硬化斑块新生血管形成被证明是最强的预测因子之一 未来的心血管事件。目前没有任何技术可用于定量 评估脆弱牌匾，这仍然是未满足的需求。 微泡是极力强大的对比度，用于超声成像 脉管系统和对比度增强了血管内超声（CE-IVUS）似乎是其中之一 最有希望的成像方式，用于检测动脉粥样硬化和脆弱的斑块。 但是，尽管该技术允许检测到Vasa vasorum，但目前CE-IVU 不提供其微体系结构的定量表征。 CE-的特异性 IVU需要改进。 对体内VASA Vasorum网络的定量评估将强烈预测 心血管事件目前尚无此类技术。我们建议使用超声 多个散射以表征新血管网络的微结构特性。经过 使用超声多散射来表征新血管形成的结构，我们 将为CE-IVUS添加一个新的维度。我们建议在这里开发的技术，CE-IVUS 不仅将用于检测相关的新血管生成，而且还用于 定量表征。这将大大提高CE-IVU的特异性 评估牌匾脆弱性。最终，它将能够对VASA进行超声波评估 流量成为广泛使用的临床工具，用于筛查，诊断和监测斑块 脆弱性。