Mentoring Diabetes Research in Oklahoma

指导俄克拉荷马州的糖尿病研究

基本信息

批准号：
9281482
负责人：
Jian-Xing Ma
金额：
$ 111万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9281482
关键词：
Affect American American Heart Association Animal Model Area Basic Science California Centers of Research Excellence Clinical Clinical Research Collaborations Communities Core Facility Development Diabetes Mellitus Diagnosis Economic Burden Fees Fostering Foundations Funding Goals Grant Growth Health Sciences High Prevalence Human Individual Institution Joints Leadership Medicine Mentors Native Americans Nutritional Science Oklahoma Older Population Paper Peer Review Phase Pilot Projects Population Positioning Attribute Prevention Program Research Project Grants Progress Reports Publications Publishing Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Research Support Resources Role Sampling Scientist Seeds Services Strategic Planning Translating Translational Research Translations Tribes United States National Institutes of Health Universities aging population career college diabetic patient improved mid-career faculty programs ranpirnase research facility social success

项目摘要

SUMMARY Oklahoma is one of the states in the US with the highest prevalence of diabetes, with 10% of the population affected. Diabetes is particularly prevalent among Native American communities, where it affects up to 40% of older individuals in some tribes. Thus, diabetes and its complications constitute a major threat to the working- age and older population, and confer an immense social and economic burden on Oklahoma. The goal of this COBRE is to enhance diabetes research in Oklahoma. In Phase I and Phase II, our COBRE achieved its milestones. All of the COBRE-supported Junior Investigators have received independent grants, including eight NIH R01 grants, two R21 grants, and multiple grants from foundations such as the American Diabetes Association and the American Heart Association. Five of our Junior Investigators have been promoted to Associate Professor, and three of them have received tenure thus far. In addition, because of their success in research, two of them received endowed chair positions. Between them, the Junior Investigators have published 207 peer-reviewed papers, 135 of which received support from COBRE-funded Cores. In collaboration with the College of Medicine, the COBRE has recruited three NIH R01-funded and 1 K99/R00-funded diabetes researchers into The University of Oklahoma Health Sciences Center (OUHSC). The COBRE-funded Cores have provided support and service to multiple PIs and supported their publications and NIH-funded grants, which enhanced diabetes research in Oklahoma. In Phase III of the COBRE program, we plan to sustain and augment these successes. We will continue supporting and mentoring Junior Investigators who graduated from the COBRE. We will expand and improve Core facilities to serve diabetes research in Oklahoma and complete transition of the COBRE-funded facilities into institutional research Cores. We will further increase the critical mass of diabetes research in Oklahoma by promoting recruitment of diabetes researchers into OUHSC. Moreover, we will continue promoting collaborative and translational research. These efforts should contribute to continuous growth of diabetes research to achieve our goal of becoming a NIH P30-funded Diabetes Research Center (DRC). This Center should greatly improve prevention and treatment of diabetes.

概括俄克拉荷马州是美国糖尿病患病率最高的州之一，有 10% 的人口患有糖尿病做作的。糖尿病在美洲原住民社区中尤为普遍，影响着多达 40% 的人一些部落中的老年人。因此，糖尿病及其并发症对工作构成重大威胁。年龄和老年人口，给俄克拉荷马州带来巨大的社会和经济负担。 COBRE 的目标是加强俄克拉荷马州的糖尿病研究。在第一阶段和第二阶段，我们的 COBRE 实现了其里程碑。所有 COBRE 支持的初级研究员都获得了独立资助，其中包括 8 项 NIH R01 拨款、2 项 R21 拨款以及来自美国基金会等基金会的多项拨款糖尿病协会和美国心脏协会。我们的五名初级研究员已晋升至副教授，其中三人迄今已获得终身教职。此外，由于他们在研究中，其中两人获得了授予的主席职位。他们之间，初级调查员发表了 207 篇同行评审论文，其中 135 篇得到了 COBRE 资助的核心的支持。与合作医学院，COBRE 招募了 3 名 NIH R01 资助的糖尿病患者和 1 名 K99/R00 资助的糖尿病患者研究人员进入俄克拉荷马大学健康科学中心（OUHSC）。 COBRE 资助的核心为多个 PI 提供了支持和服务，并支持他们的出版物和 NIH 资助的赠款，这加强俄克拉荷马州的糖尿病研究。在 COBRE 计划的第三阶段，我们计划维持和增强这些成功。我们将继续支持和指导从该学院毕业的初级研究员科布雷。我们将扩大和改善核心设施，为俄克拉荷马州的糖尿病研究服务，并完成将 COBRE 资助的设施转变为机构研究核心。我们将进一步加大关键力度通过促进 OUHSC 招募糖尿病研究人员，在俄克拉荷马州开展大量糖尿病研究。此外，我们将继续促进合作和转化研究。这些努力应该有助于糖尿病研究的不断发展，以实现我们成为 NIH P30 资助的糖尿病患者的目标研究中心（刚果民主共和国）。这个中心应该大大改善糖尿病的预防和治疗。