Infectious Disease and Basic Microbiological Mechanisms

传染病和基本微生物机制

• 批准号: 9411265
• 负责人: Marcia B Goldberg
• 金额: $ 0.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9411265
• 关键词: Communicable Diseases; Microbiology

DESCRIPTION (provided by applicant): Infectious diseases and microbiology continue to be areas of pivotal importance in health care research. Infection remains a major cause of mortality worldwide and poses serious problems of both individual and public health concern in the United States. Antibiotic resistance occurs at an alarming and increasing rate among all classes of mammalian pathogens. Moreover, diseases once thought to be near eradication from the developed world-for example, tuberculosis, cholera, and rheumatic fever-have rebounded with renewed intensity. Currently in its 36th year, the Infectious Disease and Basic Microbiological Mechanisms training program maintains as its primary goal the training of scientists who have a career goal of solving medically relevant problems and who elect rigorous laboratory or epidemiologic training in any of the Harvard adult infectious disease programs or other Harvard-based institutions participating in this program. Over the past 36 years, the program has successfully trained leaders in academic medicine and investigators who have made important contributions to the field. In this competing resubmission application, we propose an additional five years of funding and to maintain the training program at its current level of eight postdoctoral trainees slots per year. We will use these slots to provide support directly to selected infectious disease physician fellows during mentored research, and to also provide support to selected Ph.D. trainees in Harvard Medical School infectious disease and microbiology laboratories focused on areas that have significant clinical relevance, so as to support the rich research- training environment for physician-scientists within these laboratories and to provide these Ph.D. trainees intensive exposure to medically-trained clinically-active researchers. Training will include a minimum of two years of mentored research with hands-on in-laboratory training, appropriate advanced non-degree-granting post-graduate coursework, attendance and participation of trainees at regular meetings and seminars of direct relevance to infectious disease and microbiology research, and instruction in the preparation of competitive proposals for funding, with a particular emphasis on applications for K and other career development awards, including foundation awards. The specific aims of this training program are as follows: 1. To acquire sufficient training in basic laboratory or epidemiologic techniques and approaches to conduct effective leading edge research into relevant infectious disease problems; 2. To foster the creation of important scientific contributions by means of strong and longitudinal mentorship by program faculty; and 3. To develop a primary research focus and a broad understanding of infectious diseases and microbiology, so as to both enable novel interdisciplinary research and lead to independence.

描述（由申请人提供）：传染病和微生物学仍然是医疗保健研究中至关重要的领域。感染仍然是全世界死亡的主要原因，并在美国造成个人和公共健康问题的严重问题。所有类别的哺乳动物病原体中抗生素耐药性的发生率都令人震惊且不断增加。此外，曾经被认为在发达国家已接近根除的疾病——例如肺结核、霍乱和风湿热——现在又以新的强度反弹。目前，传染病和基本微生物学机制培训项目已进入第 36 个年头，其首要目标是培训科学家，他们的职业目标是解决医学相关问题，并选择接受哈佛成人传染病的严格实验室或流行病学培训。计划或参与该计划的其他哈佛大学机构。 36年来，该项目成功培养了学术医学领域的领导者和对该领域做出重要贡献的研究人员。在这个竞争性的重新提交申请中，我们提议额外提供五年的资助，并将培训计划维持在目前每年八个博士后实习生名额的水平。我们将利用这些时间段在指导研究期间直接向选定的传染病医师研究员提供支持，并向选定的博士提供支持。哈佛医学院传染病和微生物学实验室的受训人员专注于具有重要临床相关性的领域，以便为这些实验室内的医师科学家提供丰富的研究培训环境，并为这些博士学位提供机会。学员与受过医学训练的临床活跃研究人员密切接触。培训将包括至少两年的指导研究，包括实验室实践培训、适当的高级非授予学位研究生课程、受训者出席和参与与传染病和微生物学直接相关的定期会议和研讨会研究和指导准备竞争性资助提案，特别强调 K 和其他职业发展奖项（包括基金会奖项）的申请。该培训计划的具体目标如下： 1. 获得足够的基本实验室或流行病学技术和方法方面的培训，以对相关传染病问题进行有效的前沿研究； 2. 通过项目教师强有力的纵向指导，促进重要科学贡献的创造； 3. 发展对传染病和微生物学的主要研究重点和广泛的了解，以实现新颖的跨学科研究并实现独立。