Survivorship research established investigator award

生存研究设立研究者奖

基本信息

批准号：
8282597
负责人：
CHARLES L LOPRINZI
金额：
$ 15.61万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2013-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The specific aim of this grant is to mentor young clinical investigators, primarily in the area of research related to the control of symptoms caused by cancer and/or cancer therapy. A time comes in an investigator's career when a previously mentored person becomes the mentor. Although it might not be easy to admit, being more than half way through my career, I have made the transformation from primarily being mentored, to being a mentor. I am currently the Director of the Cancer Control Program of the North Central Cancer Treatment Group (NCCTG) as well as the co-director of the Cancer Prevention and Control Program of the Mayo Clinic Comprehensive Cancer Center. I have been the Principal Investigator of a community clinical oncology program (CCOP) research base grant for over a decade and have received R01 grant funding in the past. The last two competitive renewals of the CCOP research base grant that I submitted both received an identical outstanding score, that being 123. Through this effort, I have, arguably, developed the most productive program in the world designed to evaluate means of alleviating symptoms caused by cancer and/or cancer therapy. Using this background, with the funds obtained from this grant I will provide mentorship for young clinical investigators interested in a career in clinical research related to relief of symptoms from cancer and/or cancer therapy. I will use an "on-the-job" training approach to help them with the development of applicable protocols. I will mentor them through the protocol review process, through the conduct of the clinical trial, and through the process to report results as a manuscript. I will facilitate their leadership of subsections of the Mayo Oncology Symptom Control Program. I will facilitate their development of independent grant funding. I view this as a process of succession planning, expecting that one or more of these mentored individuals will eventually take my place and continue to promulgate the symptom control research program that we have here, allowing them to mentor the next generation of investigators. This role as a mentor allows me to give back to the scientific field some of the fruits from the mentoring that was provided to me in my early career. This should allow for continued investigation for promising means for alleviating symptoms related to cancer and/or cancer therapy. This will allow for improved care of patients with cancer.

描述（由申请人提供）：这笔资助的具体目的是指导年轻的临床研究人员，主要是在与控制癌症和/或癌症治疗引起的症状相关的研究领域。在调查员的职业生涯中，以前受过指导的人会成为导师。尽管承认这一点可能并不容易，但在我的职业生涯已经过半的情况下，我已经从主要接受指导转变为成为一名导师。我目前担任中北癌症治疗组 (NCCTG) 癌症控制项目主任以及梅奥诊所综合癌症中心癌症预防和控制项目联席主任。十多年来，我一直是社区临床肿瘤学计划 (CCOP) 研究基地资助的首席研究员，并且过去曾获得过 R01 资助。我提交的 CCOP 研究基础拨款的最后两次竞争性更新都获得了相同的出色分数，即 123。通过这项努力，可以说，我开发了世界上最富有成效的计划，旨在评估缓解症状的方法通过癌症和/或癌症治疗。利用这一背景，利用从这笔赠款中获得的资金，我将为对与缓解癌症和/或癌症治疗症状相关的临床研究感兴趣的年轻临床研究人员提供指导。我将使用“在职”培训方法来帮助他们制定适用的协议。我将指导他们完成方案审查过程、临床试验的进行以及将结果报告为手稿的过程。我将协助他们领导梅奥肿瘤学症状控制计划的各个部分。我将促进他们发展独立赠款资金。我认为这是一个继任计划的过程，期望这些受指导的人中的一个或多个最终能够取代我的位置，并继续颁布我们这里的症状控制研究计划，使他们能够指导下一代研究人员。作为导师的角色使我能够将我在早期职业生涯中获得的指导成果回馈给科学领域。这应该允许继续研究减轻与癌症和/或癌症治疗相关的症状的有希望的方法。这将改善癌症患者的护理。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Efficacy of nonestrogenic hot flash therapies among women stratified by breast cancer history and tamoxifen use: a pooled analysis.

按乳腺癌病史和他莫昔芬使用分层的女性中非雌性潮热疗法的疗效：汇总分析。

DOI：
发表时间：
2009-05
期刊：
影响因子：
0
作者：
Bardia, Aditya;Novotny, Paul;Sloan, Jeff;Barton, Deb;Loprinzi, Charles
通讯作者：
Loprinzi, Charles

Antiemetics for chemotherapy-induced nausea and vomiting occurring despite prophylactic antiemetic therapy.

尽管进行预防性止吐治疗，仍可使用止吐药治疗化疗引起的恶心和呕吐。

DOI：
发表时间：
2011-07
期刊：
影响因子：
2.8
作者：
Jones, Jason M;Qin, Rui;Bardia, Aditya;Linquist, Breanna;Wolf, Sherry;Loprinzi, Charles L
通讯作者：
Loprinzi, Charles L

Breast cancer survivorship issues.

乳腺癌生存问题。

DOI：
发表时间：
2013-08
期刊：
影响因子：
0
作者：
Stan, Daniela;Loprinzi, Charles L;Ruddy, Kathryn J
通讯作者：
Ruddy, Kathryn J

An analysis of fosaprepitant-induced venous toxicity in patients receiving highly emetogenic chemotherapy.

接受高致吐化疗患者福沙匹坦引起的静脉毒性分析。

DOI：
发表时间：
2015-01
期刊：
影响因子：
0
作者：
Hegerova, Livia T;Leal, Alexis D;Grendahl, Darryl C;Seisler, Drew K;Sorgatz, Kristine M;Anderson, Kari J;Hilger, Crystal R;Loprinzi, Charles L
通讯作者：
Loprinzi, Charles L

Nonhormonal management of hot flashes for women on risk reduction therapy.

对接受风险降低疗法的女性潮热进行非激素管理。