Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative Therapy

消融治疗后巴雷特食管的非内镜监测

基本信息

批准号：
9341252
负责人：
NICHOLAS J SHAHEEN
金额：
$ 17.7万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-17 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9341252
关键词：
Ablation Address Adult Area Award Back Barrett Esophagus Biological Assay Cardiac Characteristics Clinical Clinical Research Clinical Research Curriculum Award Cost Effectiveness Analysis Data Detection Development Devices Digestive System Disorders Distal Distress Dysplasia Encapsulated Endoscopic Biopsy Endoscopy Environment Epidemiology Epithelium Esophageal Esophageal Adenocarcinoma Esophageal Diseases Esophageal carcinoma Esophageal mucous membrane Esophagus Exposure to Faculty Funding Gelatin Goals Gold Grant Hepatology Incidence Indolent Industry Institution Internal Medicine Intervention Intestinal Metaplasia Investigation K-Series Research Career Programs Lead Leadership Lesion Malignant Neoplasms Medical Students Medicine Mentored Patient-Oriented Research Career Development Award Mentors Methods Mid-Career Clinical Scientist Award (K24)National Institute of Diabetes and Digestive and Kidney Diseases Neoplasms Oral cavity Patients Peer Review Population Porifera Precancerous Conditions Prevention Procedures Public Health Schools Publications Quality of life Radiofrequency Interstitial Ablation Randomized Recording of previous events Recurrence Recurrent disease Research Research Infrastructure Research Methodology Research Personnel Research Training Residencies Risk Risk Reduction Role Sampling Sedation procedure Sensitivity and Specificity Structure Supervision Techniques Time Translational Research United States National Institutes of Health Work base capsule career career development comparative effectiveness cost cost effective cost effectiveness design effectiveness trial gastric secretion substance improved indexing medical schools minimally invasive mortality neoplastic next generation novel outcome forecast patient oriented research patient population professor programs prospective public health relevance ranpirnase screening skills standard of care tool translational research program trefoil factor

项目摘要

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award supports Nicholas J. Shaheen, MD, MPH, a Professor of Medicine at UNC, and an Adjunct Professor of Epidemiology at the School of Public Health. Candidate: Dr. Shaheen completed an NIDDK K23 award six years ago, and now is at the midcareer level. He has a highly successful program in patient-oriented research in the prevention, detection and treatment of esophageal neoplasia, with >100 peer-reviewed publications in these areas, an H index of 33, and almost 800 citations of his work in 2012. He has a breadth of research funding, including his role as a PI of NCI's Barrett's Esophagus Translational Research Network (BETRNet), a major project within a U54 grant, co-investigator status on several other NIH grants, and multiple societal & industry grants. Dr. Shaheen has a documented history of successful mentoring of trainees at the medical student, resident and fellow level, including multiple societal and K awards. Twenty of his 31 peer-reviewed publications in 2012 featured trainee authors. This mid-career investigator award will protect Dr. Shaheen's time to focus on patient-oriented research and on mentoring trainees. His immediate objectives are: 1) To expand a rigorous clinical and translational research program in neoplastic conditions of the esophagus; 2) To provide highly structured, appropriately supervised, and fruitful research opportunities for mentees; 3) To enhance his skills in research methodology; 4) To improve his mentoring and leadership skills; and, 5) To provide career development to trainees. His long-term objectives are: 1) To decrease mortality from esophageal carcinoma by improving screening and therapy; 2) To expand the UNC research center for esophageal diseases; and 3) To contribute to the development of the next generation of clinical researchers in digestive diseases. Environment: There is an outstanding pool of potential mentees, due in part to his institution's T32 program in clinical research (R. Sandler, PI). Other mentees come from UNC's highly competitive and academic internal medicine residency, its outstanding School of Public Health, and the School of Medicine. UNC's CTSA award, its K30 program, the School of Public Health and the GI Division's Digestive Diseases Research Center (P30) provide a remarkably rich environment for patient-oriented research training in digestive diseases and hepatology, as evidenced by the multiple successful past trainees of the program. Research: Dr. Shaheen proposes a novel research plan, aimed at addressing the issue of surveillance following endoscopic ablation for dysplastic Barrett's esophagus (BE). Using a recently-developed non-endoscopic device, the Cytosponge, he will perform a comparative effectiveness trial assessing the accuracy of this device in detecting recurrent BE following successful radiofrequency ablation. If this device is able to detect BE in this group, it will open the door for subsequent investigations assessing its utility in other clincal settings. Importantly, given the purposes of this application, this study offers multiple opportunities for the involvement of his mentees, including roles in the design, implementation and analysis of the study. Currently, Dr. Shaheen's mentoring efforts are unfunded, and occur as his clinical duties and research program allow. His current funding protects no time for mentoring. Given the expansion of both his research program and the clinical requirements of his institution, mentoring is becoming more difficult. This K24 award will provide essential support for the candidate to meet his mentoring and research goals.

描述（由申请人提供）：该K24中级研究员奖支持UNC的医学教授Nicholas J. Shaheen，MPH，MPH，公共卫生学院的流行病学兼职教授。候选人：Shaheen博士在六年前完成了NIDDK K23奖，现在处于中级职业级别。他在预防，检测和治疗食管肿瘤方面具有非常成功的计划，在这些领域拥有> 100个同行评审的出版物，h指数为33，在2012年进行了近800份引用，他在2012年的工作中进行了近800份。 Grant，其他几项NIH赠款的共同投资者身份以及多个社会和工业赠款。 Shaheen博士在医学生，居民和其他层面上成功指导学员的历史记录了，包括多个社会和K奖。 2012年，他的31个同行评审出版物中有二十个是学员作者。这项职业中期调查员奖将保护Shaheen博士的时间专注于以患者为导向的研究和指导学员。他的直接目标是：1）在食管的肿瘤状况下扩大严格的临床和转化研究计划； 2）为受训者提供高度结构化，适当监督和富有成果的研究机会； 3）增强他在研究方法论方面的技能； 4）提高他的指导和领导能力； 5）为学员提供职业发展。他的长期目标是：1）通过改善筛查和治疗来降低食道癌的死亡率； 2）扩大UNC食管疾病研究中心； 3）为消化疾病中的下一代临床研究人员的发展做出贡献。环境：有一大批潜在的受训者，部分原因是他的机构的T32临床研究计划（R. Sandler，PI）。其他受训者来自UNC竞争激烈的学术内科住院医师，其出色的公共卫生学院和医学院。 UNC的CTSA奖，其K30计划，公共卫生学院和GI部的消化疾病研究中心（P30）为消化疾病和肝病学的患者研究培训提供了一个非常丰富的环境，这是该计划的多个成功学员所证明的。研究：Shaheen博士提出了一项新的研究计划，旨在解决内窥镜消融后的监测问题，用于发育不良的Barrett食管（BE）。使用最近开发的非内镜设备The Cytosponge，他将进行比较有效性试验，以评估该设备在检测复发的准确性后，是在成功的射频消融后进行的。如果该设备能够在此组中检测到，它将为随后的调查打开大门，以评估其在其他Clincal设置中的效用。重要的是，鉴于本应用的目的，本研究为受训者的参与提供了多种机会，包括在研究，实施和分析中的作用。目前，Shaheen博士的指导工作是没有资金的，并且是因为他的临床职责和研究计划允许。他目前的资金没有任何时间进行指导。鉴于他的研究计划和机构的临床要求都扩大了，指导变得越来越困难。这项K24奖将为候选人提供基本的支持，以实现他的指导和研究目标。