Non-Endoscopic Surveillance for Barrett's Esophagus Following Ablative Therapy

消融治疗后巴雷特食管的非内镜监测

基本信息

批准号：
9341252
负责人：
NICHOLAS J SHAHEEN
金额：
$ 17.7万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-17 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9341252
关键词：
Ablation Address Adult Area Award Back Barrett Esophagus Biological Assay Cardiac Characteristics Clinical Clinical Research Clinical Research Curriculum Award Cost Effectiveness Analysis Data Detection Development Devices Digestive System Disorders Distal Distress Dysplasia Encapsulated Endoscopic Biopsy Endoscopy Environment Epidemiology Epithelium Esophageal Esophageal Adenocarcinoma Esophageal Diseases Esophageal carcinoma Esophageal mucous membrane Esophagus Exposure to Faculty Funding Gelatin Goals Gold Grant Hepatology Incidence Indolent Industry Institution Internal Medicine Intervention Intestinal Metaplasia Investigation K-Series Research Career Programs Lead Leadership Lesion Malignant Neoplasms Medical Students Medicine Mentored Patient-Oriented Research Career Development Award Mentors Methods Mid-Career Clinical Scientist Award (K24)National Institute of Diabetes and Digestive and Kidney Diseases Neoplasms Oral cavity Patients Peer Review Population Porifera Precancerous Conditions Prevention Procedures Public Health Schools Publications Quality of life Radiofrequency Interstitial Ablation Randomized Recording of previous events Recurrence Recurrent disease Research Research Infrastructure Research Methodology Research Personnel Research Training Residencies Risk Risk Reduction Role Sampling Sedation procedure Sensitivity and Specificity Structure Supervision Techniques Time Translational Research United States National Institutes of Health Work base capsule career career development comparative effectiveness cost cost effective cost effectiveness design effectiveness trial gastric secretion substance improved indexing medical schools minimally invasive mortality neoplastic next generation novel outcome forecast patient oriented research patient population professor programs prospective public health relevance ranpirnase screening skills standard of care tool translational research program trefoil factor

项目摘要

DESCRIPTION (provided by applicant): This K24 Mid-Career Investigator Award supports Nicholas J. Shaheen, MD, MPH, a Professor of Medicine at UNC, and an Adjunct Professor of Epidemiology at the School of Public Health. Candidate: Dr. Shaheen completed an NIDDK K23 award six years ago, and now is at the midcareer level. He has a highly successful program in patient-oriented research in the prevention, detection and treatment of esophageal neoplasia, with >100 peer-reviewed publications in these areas, an H index of 33, and almost 800 citations of his work in 2012. He has a breadth of research funding, including his role as a PI of NCI's Barrett's Esophagus Translational Research Network (BETRNet), a major project within a U54 grant, co-investigator status on several other NIH grants, and multiple societal & industry grants. Dr. Shaheen has a documented history of successful mentoring of trainees at the medical student, resident and fellow level, including multiple societal and K awards. Twenty of his 31 peer-reviewed publications in 2012 featured trainee authors. This mid-career investigator award will protect Dr. Shaheen's time to focus on patient-oriented research and on mentoring trainees. His immediate objectives are: 1) To expand a rigorous clinical and translational research program in neoplastic conditions of the esophagus; 2) To provide highly structured, appropriately supervised, and fruitful research opportunities for mentees; 3) To enhance his skills in research methodology; 4) To improve his mentoring and leadership skills; and, 5) To provide career development to trainees. His long-term objectives are: 1) To decrease mortality from esophageal carcinoma by improving screening and therapy; 2) To expand the UNC research center for esophageal diseases; and 3) To contribute to the development of the next generation of clinical researchers in digestive diseases. Environment: There is an outstanding pool of potential mentees, due in part to his institution's T32 program in clinical research (R. Sandler, PI). Other mentees come from UNC's highly competitive and academic internal medicine residency, its outstanding School of Public Health, and the School of Medicine. UNC's CTSA award, its K30 program, the School of Public Health and the GI Division's Digestive Diseases Research Center (P30) provide a remarkably rich environment for patient-oriented research training in digestive diseases and hepatology, as evidenced by the multiple successful past trainees of the program. Research: Dr. Shaheen proposes a novel research plan, aimed at addressing the issue of surveillance following endoscopic ablation for dysplastic Barrett's esophagus (BE). Using a recently-developed non-endoscopic device, the Cytosponge, he will perform a comparative effectiveness trial assessing the accuracy of this device in detecting recurrent BE following successful radiofrequency ablation. If this device is able to detect BE in this group, it will open the door for subsequent investigations assessing its utility in other clincal settings. Importantly, given the purposes of this application, this study offers multiple opportunities for the involvement of his mentees, including roles in the design, implementation and analysis of the study. Currently, Dr. Shaheen's mentoring efforts are unfunded, and occur as his clinical duties and research program allow. His current funding protects no time for mentoring. Given the expansion of both his research program and the clinical requirements of his institution, mentoring is becoming more difficult. This K24 award will provide essential support for the candidate to meet his mentoring and research goals.

描述（由申请人提供）：该 K24 职业生涯中期研究员奖支持 Nicholas J. Shaheen（医学博士、公共卫生硕士）、北卡罗来纳大学医学教授和公共卫生学院流行病学兼职教授。候选人：Shaheen 博士六年前获得了 NIDDK K23 奖项，现在处于职业生涯中期。他在预防、检测和治疗食管肿瘤方面以患者为导向的研究项目非常成功，在这些领域发表了超过 100 篇同行评审出版物，H 指数为 33，2012 年他的工作被引用了近 800 次。拥有广泛的研究经费，包括担任 NCI 巴雷特食管转化研究网络 (BETRNet) 的 PI，该网络是一个重大项目U54 资助、其他几项 NIH 资助的联合研究员身份以及多项社会和行业资助。 Shaheen 博士拥有成功指导医学生、住院医师和研究员级别学员的记录，包括多项社会奖和 K 奖。 2012 年，他发表了 31 篇同行评审出版物，其中有 20 篇以实习作者为特色。这项职业生涯中期研究员奖将保护 Shaheen 博士有时间专注于以患者为导向的研究和指导学员。他的近期目标是： 1）扩大食管肿瘤条件下严格的临床和转化研究计划； 2）为学员提供高度结构化、适当监督和富有成效的研究机会； 3）提高研究方法的技能； 4）提高指导和领导能力； 5) 为学员提供职业发展。他的长期目标是： 1）通过改进筛查和治疗来降低食管癌的死亡率； 2) 扩大北卡罗来纳大学食管疾病研究中心； 3) 为下一代消化系统疾病临床研究人员的发展做出贡献。环境：有大量优秀的潜在受训者，部分原因是他所在机构的临床研究 T32 计划（R. Sandler，PI）。其他学员来自北卡罗来纳大学竞争激烈、学术性强的内科住院医师实习、杰出的公共卫生学院和医学院。北卡罗来纳大学的 CTSA 奖、其 K30 项目、公共卫生学院和胃肠病学部消化疾病研究中心 (P30) 为消化疾病和肝病学领域以患者为导向的研究培训提供了非常丰富的环境，这一点从过去的多名成功学员中得到了证明。程序。研究：Shaheen 博士提出了一项新颖的研究计划，旨在解决发育不良巴雷特食管 (BE) 内镜消融术后的监测问题。他将使用最近开发的非内窥镜设备 Cytosponge 进行一项比较有效性试验，评估该设备在成功射频消融后检测复发性 BE 的准确性。如果该设备能够检测到该组中的BE，它将为后续研究打开大门，评估其在其他临床环境中的效用。重要的是，考虑到本申请的目的，本研究为其学员提供了多种参与机会，包括在研究的设计、实施和分析中的角色。目前，Shaheen 博士的指导工作没有资金支持，并且是在他的临床职责和研究计划允许的情况下进行的。他目前的资金保障没有时间进行指导。鉴于他的研究项目和所在机构的临床需求的扩大，指导变得更加困难。该 K24 奖项将为候选人提供必要的支持，以实现他的指导和研究目标。