Risk Prediction of Symptomatic Gallbladder Disease

有症状的胆囊疾病的风险预测

基本信息

批准号：
9333361
负责人：
Amit Dolar Joshi
金额：
$ 15.88万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9333361
关键词：
Abdominal Pain Address Admission activity Advisory Committees Age Area Award Bile Acids Biliary Biological Biological Markers CYP7A1 gene Center for Translational Science Activities Cholecystectomy Cholelithiasis Cholesterol Chronic Disease Clinic Clinical Clinical Sciences Clinical effectiveness Colorectal Adenoma Computer Simulation Data Diabetes Mellitus Digestive System Disorders Disease Economic Burden Ensure Environment Epidemiologist Epidemiology Faculty Feedback Female Follow-Up Studies Foundations Framingham Heart Study Gall Bladder Diseases Gallbladder Gastroenterology Gastrointestinal Diseases Gene Expression Genes Genetic Genetic Markers Genetic Predisposition to Disease Genetic Transcription Goals Health Health Care Costs Health Professional Hormone use Hospitals Individual International K-Series Research Career Programs Knowledge Life Style Link Medicine Menopause Mentors Meta-Analysis Metabolic Metabolic syndrome Metabolism Methodology Modality Modeling Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Nurses&apos Health Study Obesity Operative Surgical Procedures Pain Participant Pathway interactions Patient observation Patients Plasma Population Study Post-Translational Protein Processing Public Health Schools Recurrence Research Research Infrastructure Research Priority Resources Risk Risk Factors Risk stratification Science Supervision Symptoms Testing Training United States Unnecessary Surgery Work base cancer risk career clinical epidemiology clinical practice clinical predictors clinical translation cohort comparative effectiveness cost cost effective cost effectiveness cost-effectiveness evaluation critical developmental period epigenetic regulation experience gastrointestinal gene environment interaction genome wide association study improved lifestyle factors markov model metabolomics multidisciplinary novel novel marker outcome prediction patient oriented research patient stratification persistent symptom personalized care population based precision medicine programs public health relevance response sex skills tool training opportunity translational scientist

项目摘要

PROJECT SUMMARY/ ABSTRACT This K01 career development award applicant is trained as a genetic epidemiologist and his research has genome wide association studies (GWAS) of gastrointestinal diseases such as colorectal adenoma and gallstone disease. He recently led a study that identified novel genetic markers of gallstone disease in a GWAS meta-analyses within 10 international cohorts. In this proposal, the candidate seeks to continue his work on gallbladder disease, and work on application of knowledge from `omic' studies, into the clinic for individualized patient care. He plans to develop metabolomics based biomarkers to predict the risk of symptomatic gallbladder disease. He will then determine their clinical effectiveness in predicting persistence of symptoms in cholecystectomy patients, and the cost-effectiveness of these biomarker tools using mathematical simulation models. The overarching hypothesis of this proposal is that metabolomic signatures can accurately distinguish patients with biliary-type pain that are more likely to benefit from cholecystectomy from those for whom cholecystectomy may be unnecessary. This proposal will allow him to expand his training from the population-based setting to patient oriented research, and gain experience in comparative effectiveness analyses. To complete this proposal, the candidate will require additional training in the areas of decision sciences, patient oriented research and metabolomics. He will benefit from a multidisciplinary mentoring committee, consisting of internationally recognized experts in gastroenterology, clinical epidemiology, health decision sciences, biomarker epidemiology, and metabolomics. His training plan, developed with close supervision of his mentoring committee, will include didactic coursework at HSPH with the objective to gain fluency with key concepts in these training areas. The candidate's primary mentor Dr. Andrew T. Chan has an established track record of effectively mentoring fellows and junior faculty towards successful academic careers. His research advisory committee will not only provide methodological expertise, but also mentoring support, guidance and critical focused so far on gene-environment interactions in the risk of cancers, and feedback to ensure the candidate's transition towards independence . The research environment, which includes MGH Clinical and Translational Epidemiology Unit, MGH Division of Gastroenterology, the Channing Division of Network Medicine, The Harvard Clinical and Translational Science Center and the Harvard T H Chan School of Public Health will provide vast collaborative resources, relevant advanced course-work, seminars and other didactic training opportunities for the candidate during this critical developmental period. Through this award, the candidate will realize his long term goal of becoming an independent translational investigator, and establishing a research program in a clinical setting, with specific focus on gastrointestinal diseases.

项目概要/摘要这位K01职业发展奖申请人接受过遗传流行病学家培训，他的研究成果全基因组关联研究（GWAS）胃肠道疾病，如结直肠腺瘤和胆结石疾病。他最近领导了一个研究在 10 年内通过 GWAS 荟萃分析确定了胆石病的新遗传标记国际队列。在此提案中，候选人寻求继续他在胆囊疾病方面的工作，并且致力于将“组学”研究的知识应用到临床中以实现个性化患者护理。他计划开发基于代谢组学的生物标志物来预测有症状的胆囊疾病的风险。然后他会确定其在预测胆囊切除术患者症状持续性方面的临床有效性，以及使用数学模拟模型评估这些生物标记工具的成本效益。首要的该提案的假设是代谢组学特征可以准确地区分胆道型患者对于那些可能接受胆囊切除术的人来说，更有可能从胆囊切除术中受益的疼痛不必要。该提案将使他能够将培训从基于人群的环境扩展到患者定向研究，并获得比较有效性分析的经验。为了完成这项提案，候选人将需要在决策科学、以患者为导向的研究和代谢组学。他将受益于一个多学科指导委员会，该委员会由国际胃肠病学、临床流行病学、健康决策科学、生物标志物领域的公认专家流行病学和代谢组学。他的训练计划是在他的指导的密切监督下制定的委员会，将包括 HSPH 的教学课程，目的是流利地掌握以下领域的关键概念这些培训领域。候选人的主要导师 Andrew T. Chan 博士拥有以下良好记录：有效地指导研究员和初级教师走向成功的学术生涯。他的研究咨询委员会不仅将提供方法论专业知识，还将提供指导支持、指导和关键到目前为止，重点关注癌症风险中基因与环境的相互作用，以及反馈给确保候选人向独立过渡。研究环境，包括 MGH 临床和转化流行病学部门、MGH 胃肠病学部门、钱宁哈佛临床与转化科学中心和哈佛 T H 网络医学部陈公共卫生学院将提供大量的合作资源、相关的高级课程、在此关键发展时期为候选人提供研讨会和其他教学培训机会。通过该奖项，候选人将实现成为独立翻译家的长期目标研究者，并在临床环境中建立一个研究计划，特别关注胃肠道疾病。