Interdisciplinary Research in Vascular Biology

血管生物学的跨学科研究

基本信息

批准号：
9072892
负责人：
RODGER PAUL MCEVER
金额：
$ 129.38万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-15 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9072892
关键词：
Biology Biology of Aging Blood Vessels Caliber Capital Cardiovascular Pathology Cardiovascular Physiology Cardiovascular system Cell Nucleus Centers of Research Excellence Complex Core Facility Development Diagnosis Ensure Environment Equipment Faculty Recruitment Fees Fostering Foundations Free Radicals Funding Future Goals Grant In Vitro Interdisciplinary Study Journals Malignant Neoplasms Medical Research Mentors Methods Microscope Microscopy Myocardial Infarction Oklahoma Paper Phase Phenotype Philosophy Pilot Projects Positioning Attribute Productivity Publications Publishing Recruitment Activity Research Research Personnel Research Project Grants Resource Allocation Scientist Services Source Stroke Tissue imaging United States National Institutes of Health Wages base career career development human disease improved in vivo innovation interdisciplinary approach laboratory equipment multidisciplinary new technology next generation programs public health relevance success

项目摘要

DESCRIPTION (provided by applicant): In this COBRE Phase III application, we will move to independence a world-class center of excellence in vascular biology at the Oklahoma Medical Research Foundation (OMRF). In Phases I and II, we fostered vascular biology research through a multidisciplinary approach. Mentoring launched the independent careers of outstanding junior investigators, who developed innovative new technologies, published papers in top-tier journals, and competed successfully for multiple grants from NIH, DOD, NSF, and other sources. We supported development of core facilities that enhanced the research projects. Several of our scientific cores are already financially independent. In Phase III we will expand and transition to sustainability two scientific cores that support cardiovascular research for all COBRE investigators and for non-COBRE investigators. The Microscopy Core provides unique expertise to image tissues in vitro and in vivo using state-of-the-art microscopes. The Phenotyping Core provides unique expertise and equipment to assess cardiovascular physiology and pathology. The Pilot Core will identify and support innovative pilot projects from COBRE- eligible junior investigators. These will expand the scope and depth of research within the Center and further improve competitiveness for funding. The Administrative Core will coordinate the scientific cores, assist with regulatory requirements, evaluate the pilot projects, and, most importantly, nurture our strong mentoring environment to ensure its sustainability. OMRF will continue to partner with the COBRE through commitments to salaries, capital equipment, laboratory space, and faculty recruitment. Phase III funding will ensure our transition to a self-sustaining research center in vascular biology of the highest caliber.

描述（由应用程序提供）：在此COBRE III阶段应用中，我们将在俄克拉荷马州医学研究基金会（OMRF）的世界一流血管生物学卓越中心。在第I和II阶段，我们通过多学科方法培养了血管生物学研究。指导推出了杰出的初级调查人员的独立职业，他们开发了创新的新技术，在顶级期刊上发表了论文，并成功地为来自NIH，DOD，NSF和其他来源的多项赠款竞争。我们支持开发增强研究项目的核心设施。我们的几个科学核心已经在财务上是独立的。在第三阶段，我们将扩展并过渡到可持续性的两个科学核心，这些科学核心支持所有毛病研究人员和非近代研究人员的心血管研究。显微镜核心为使用最先进的显微镜在体外和体内形象组织提供了独特的专业知识。呼吸型核心提供了独特的专业知识和设备来评估心血管生理学和病理学。飞行员核心将识别并支持有资格的初级调查人员的创新试点项目。这些将扩大中心内研究的范围和深度，并进一步提高资金的竞争力。行政核心将协调科学核心，协助监管要求，评估试点项目，最重要的是，护理我们强大的心理环境以确保其可持续性。 OMRF将通过对薪水，资本设备，实验室空间和教职员工招聘的承诺继续与COBRE合作。第三阶段的资金将确保我们过渡到最高口径血管生物学的自我维持研究中心。