Mobile cognitive control training for the treatment of Alcohol Use Disorder and Post Traumatic Stress Disorder

用于治疗酒精使用障碍和创伤后应激障碍的移动认知控制训练

• 批准号: 9409534
• 负责人: Hyun Kyu Lee
• 金额: $ 22.47万
• 依托单位: POSIT SCIENCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9409534
• 关键词: Activities of Daily Living; Address; Alcohol consumption; Alcohols; Area; Attention; Chronic; Clinic; Clinical; Cognitive; Cognitive deficits; Collaborations; Complex; Computer Systems; Computer software; Cues; Data; Development; Disease; Economic Burden; Ensure; Exercise; Feasibility Studies; Feedback; Focus Groups; General Population; Goals; Healthcare Systems; Home environment; Impairment; Impulsivity; Individual; Informal Social Control; Instruction; Intervention; Measures; Mediating; Memory; Methods; Modeling; Monitor; Neurocognitive; Neuropsychological Tests; Outcome; Outcome Measure; Patient Self-Report; Patients; Performance; Phase; Pilot Projects; Play; Population; Post-Traumatic Stress Disorders; Problem Solving; Process; Program Acceptability; Psyche structure; Psychiatric Diagnosis; Psychopathology; Quality of life; Questionnaires; Readiness; Recovery; Research; Research Personnel; Rewards; Role; Schedule; Science; Scientist; Self Management; Short-Term Memory; Software Design; Stigmatization; Stimulus; Substance Use Disorder; Symptoms; Target Populations; Training; Training Programs; Treatment outcome; alcohol abuse therapy; alcohol comorbidity; alcohol monitoring; alcohol seeking behavior; alcohol use disorder; alternative treatment; attentional bias; base; brain health; cloud based; cognitive ability; cognitive control; cognitive enhancement; cognitive function; cognitive system; cognitive training; compliance behavior; cost; design; efficacy trial; evidence base; executive function; experience; flexibility; functional outcomes; improved; indexing; innovation; mobile application; novel; novel therapeutics; phase 2 study; phase II trial; programs; remediation; restoration; skills; social; social stigma; software development; stress disorder; tool; treatment program; usability; web site

Project Summary Abstract The primary objective of the current project is to develop and evaluate the feasibility of mobile cognitive- control training program for the treatment of those who are suffering from co-morbid Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD). Unlike previous AUD interventions that may overlook the role of co-occurring psychopathology, those that target “trans-disease” cognitive deficits for remediation represent an innovative, evidence-based, and potentially high-yield approach for optimizing recovery outcomes and reducing chronic impairment among vulnerable individuals with co-occurring AUD and PTSD. This novel therapeutic strategy is designed to (1) broadly assess cognitive and functional abilities, then (2) train cognitive abilities with the specific goal of strengthening cognitive systems that mediate core deficits in AUD and PTSD, and (3) continuously inform clinicians about patient compliance and treatment progress via a Cloud-based patient-to-clinic portal. Also, brief self-report of daily alcohol use and PTSD status shall provide data useful for both evaluating real-world outcomes and product model acceptability. In the first specific aim, we will define a set of enhancements to make the user experience and the game play sufficient to motivate the continued use of the program. We will then employ established methods of software design and development and iteratively refine the implemented design to complete the development of the enhanced program for a feasibility trial (specific aim 2) conducted locally, in collaboration with the research team at the Palo Alto VA Health Care System. Given the ease of access of mobile-based training and online monitoring of AUD-PTSD status, this project should result in the development of a new, powerful tool to provide effective adjunctive therapy that results in far greater treatment outcome among individuals with co-occurring AUD and PTSD.

项目概要摘要 当前项目的主要目标是开发和评估移动认知的可行性 针对患有共病酒精使用障碍的患者的治疗控制培训计划 (AUD) 和创伤后应激障碍 (PTSD) 与之前的 AUD 干预措施不同，后者可能会忽视以下问题： 共同发生的精神病理学的作用，针对“跨疾病”认知缺陷进行补救 代表了一种创新的、基于证据的、潜在的高收益方法，用于优化恢复结果 减少同时患有 AUD 和 PTSD 的弱势群体的慢性损伤。 治疗策略旨在 (1) 广泛评估认知和功能能力，然后 (2) 训练认知能力 能力，其具体目标是加强调解 AUD 和 PTSD 核心缺陷的认知系统， (3) 通过基于云的持续告知患者依从性和治疗进展 此外，每日饮酒情况和创伤后应激障碍 (PTSD) 状态的简短自我报告应提供有用的数据。 评估现实世界的结果和产品模型的可接受性在第一个具体目标中，我们将定义一个 一系列增强功能，使用户体验和游戏玩法足以激励继续使用 然后，我们将采用既定的软件设计和开发方法并迭代。 完善已实施的设计，完成可行性试验的增强方案的开发 （具体目标 2）与 Palo Alto VA Health Care 的研究团队合作在当地进行 考虑到基于移动的培训和在线监测 AUD-PTSD 状态的便捷性，该系统。 该项目应开发出一种新的、强大的工具来提供有效的辅助治疗， 对于同时患有 AUD 和 PTSD 的个体来说，其治疗效果要好得多。