Genetic and Trait Influences on Pain Heterogeneity

遗传和性状对疼痛异质性的影响

基本信息

批准号：
8289500
负责人：
Laura A Frey Law
金额：
$ 12.05万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-08 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8289500
关键词：
ADRB2 gene ASIC channel Acute Pain Adrenergic Agents Affect Animals Anxiety Biological Candidate Disease Gene Caring Carpal Tunnel Syndrome Catecholamines Clinical Clinical Research Complex Cutaneous Muscle Decision Making Degenerative polyarthritis Diagnosis Diagnostic Dissociation Emotional Environment Enzymes Evidence based practice Exposure to Female Fibromyalgia Fright Gender Gender Role Genes Genetic Genetic Drift Genotype Goals Healthcare Heterogeneity Hospitals Human Hyperalgesia Individual Individual Differences Inflammation Infusion procedures Injury Intramuscular Investigation Ischemia Joint Commission on Accreditation of Healthcare Organizations Lead Link Low Back Pain Measurable Measures Mechanics Mediating Medical Metabolic Methyltransferase Methyltransferase Gene Modeling Muscle Musculoskeletal Pain Myalgia Neurotic Disorders Nociception Nociceptive Stimulus Nociceptors Opioid Osteoporosis Outcome Pain Pain intensity Pain-Free Pathology Pathway interactions Patient Care Patients Perception Peripheral Personality Personality Traits Phosphate Buffer Play Population Postoperative Pain Predictive Value Process Psychological Factors Quality of life Replacement Arthroplasty Reporting Research Research Training Role Sensory Severities Sex Characteristics Single Nucleotide Polymorphism Societies Source Stimulus Syndrome TRPV1 gene Testing Tissues Training Treatment outcome Variant adrenergic base biopsychosocial chronic pain clinical care clinical decision-making clinically relevant disability emotional experience expectation experience human subject improved insight male medical attention multidisciplinary novel patient population psychologic response sex social somatosensory trait translational study treatment planning treatment strategy vanilloid receptor subtype 1 willingness

项目摘要

DESCRIPTION (provided by applicant): Pain, an unpleasant sensory and emotional experience, is a significant often under-recognized medical problem spanning numerous patient populations. One of the leading causes for individuals to seek medical attention is musculoskeletal pain. Indeed, pain is now considered the 5th vital sign. Unfortunately, pain is highly variable between individuals. In both acute and chronic pain conditions, there is often a dissociation of pain perception and the underlying pathology in a variety of conditions such as low back pain, osteoporosis or osteoarthritis. Significant pain that is disproportionate to the physical findings is challenging to treat and can result in decreased quality of life and greater disability. Thus, pain heterogeneity associated with common clinical conditions Interferes with diagnosis and adequate treatment, ultimately compromising healthcare. The biopsychosocial model of pain suggests pain perception is a complex process that involves a myriad of physical, social, and emotional components. While no one factor can explain pain heterogeneity, individual differences in gender, genotype, and psychological traits may play a significant role. Unfortunately, it is difficult to find individuals with adequate multidisciplinary training to investigate pain from a multi-factorial perspective. Thus, the goal of the proposed research and training is to gain the expertise to determine the degree to which measurable Individual differences, e.g. sex, genotype and personality traits, predict high and low pain responses. This translational study approach utilizes a controlled, deep-tissue, algesic stimulus in human subjects to critically examine factors that contribute to pain heterogeneity. The Intramuscular infusion of an acidic phosphate buffer provides a clinically-relevant nociceptive stimulus of deep-tissue pain. This novel model provides a unique opportunity to study the Influence of baseline individual differences without the confounding factors associated with clinical pain syndromes. RELEVANCE: Musculoskeletal pain is a prevalent problem in our society and pain heterogeneity between individuals may result from multiple factors. This research plan will assess the role of normal personality traits, sex, and genotype on muscle pain sensitivity. This information may improve diagnosis and treatment strategies for musculoskeletal pain, advancing healthcare through increasingly individualized patient care approaches.

描述（由申请人提供）：疼痛是一种令人不愉快的感觉和情绪体验，是影响众多患者群体的一个重要的、经常被忽视的医疗问题。人们寻求医疗救助的主要原因之一是肌肉骨骼疼痛。事实上，疼痛现在被认为是第五生命体征。不幸的是，疼痛在个体之间存在很大差异。在急性和慢性疼痛的情况下，疼痛感知与各种病症（例如腰痛、骨质疏松症或骨关节炎）的潜在病理学常常是分离的。与身体检查结果不成比例的剧烈疼痛很难治疗，并且可能导致生活质量下降和更大的残疾。因此，与常见临床病症相关的疼痛异质性会干扰诊断和充分治疗，最终损害医疗保健。疼痛的生物心理社会模型表明疼痛感知是一个复杂的过程，涉及无数的身体、社会和情感成分。虽然没有任何一种因素可以解释疼痛的异质性，但性别、基因型和心理特征的个体差异可能发挥重要作用。不幸的是，很难找到受过充分多学科培训的个人来从多因素的角度研究疼痛。因此，拟议的研究和培训的目标是获得专业知识，以确定可测量的个体差异的程度，例如性别、基因型和性格特征可以预测疼痛反应的高低。这种转化研究方法利用人体受控的深层组织痛觉刺激来严格检查导致疼痛异质性的因素。肌肉内输注酸性磷酸盐缓冲液可提供临床相关的深部组织疼痛伤害性刺激。这种新颖的模型提供了一个独特的机会来研究基线个体差异的影响，而无需与临床疼痛综合征相关的混杂因素。相关性：肌肉骨骼疼痛是我们社会中的一个普遍问题，个体之间的疼痛异质性可能是由多种因素造成的。该研究计划将评估正常人格特征、性别和基因型对肌肉疼痛敏感性的作用。这些信息可以改善肌肉骨骼疼痛的诊断和治疗策略，通过日益个性化的患者护理方法推进医疗保健。