Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program

预防老龄化人口中的感染和抗生素耐药性：转化研究和培训计划

基本信息

批准号：
9232068
负责人：
Lona Mody
金额：
$ 16.98万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9232068
关键词：
Admission activity Adult Age Age-Years Aging Antibiotics Antimicrobial Resistance Applications Grants Award Bacillus (bacterium)Basic Science Capsicum Caregivers Caring Clinical Clinical Research Clostridium difficile Collaborations Communicable Diseases Comorbidity Data Data Set Development Devices Disabled Persons Discipline of Nursing Education Elderly Environment Epidemiology Faculty Fostering Foundations Frail Elderly Frail Older Adults Funding Future Generations Genomics Geography Geriatrics Goals Grant Health Healthcare Home Nursing Care Home environment Hospitalization Hospitals Infection Infection Control Infection prevention Infectious Disease Epidemiology Institution International Laboratories Laboratory Research Learning Length of Stay Life Location Long-Term Care Maps Mentors Methodology Methods Michigan Microbe Microbiology Modeling Molecular Molecular Epidemiology Morbidity - disease rate Multiple Anatomic Sites Nurses Nursing Homes Older Population Organism Outcome Outcomes Research Pathway interactions Policies Population Prevalence Prevention Research Program Development Public Health Schools Quality of Care Randomized Research Research Methodology Research Personnel Resistance Resistance to infection Resources Risk Risk Factors Risk stratification Role Safety Saints Sampling Scholarship Stream Students Subgroup Techniques Testing Training Training Programs Training Support Translational Research Unemployment United States United States Agency for Healthcare Research and Quality United States National Institutes of Health Universities Vancomycin resistant enterococcus Vulnerable Populations Work aging population base career career development clinical candidate clinical epidemiology clinical practice clinically significant community based participatory research design evidence base functional disability functional status genome sequencing high risk hospice environment implantable device improved outcome innovation interest methicillin resistant Staphylococcus aureus microbiome mortality multi-component intervention multi-drug resistant pathogen multidisciplinary next generation pathogen patient oriented patient oriented research patient safety programs public health relevance skill acquisition skills translational study transmission process vector

项目摘要

DESCRIPTION (provided by applicant): The candidate's career objective is to develop a nationally and internationally known program in `Infection Prevention in Aging'. The candidate will achieve this objective by conducting patient-oriented research that improves outcomes from infectious diseases and reduces antimicrobial resistance in a vulnerable older population and by training a multidisciplinary group of students, residents, fellows, nurse investigators and junior faculty who wish to conduct patient-oriented and outcomes research in infection prevention. The majority of the candidate's professional life has been dedicated to the conduct of patient-oriented research in infection prevention, establish a steady stream of research funding and organize numerous career-development programs in aging research nationally. Translation of research findings into clinical practice, particularly in nursing homes, is challenging. Frail olde adults who receive care in institutional settings are a particularly high risk of poor outcomes. Training a multidisciplinary group of junior investigators is key to design evidence-based randomized studies to test innovative models and practices that reduce infections and antimicrobial resistance in nursing homes. Thus, the overall aims of this proposal are: Aim 1: To enhance the candidate's capacity to effectively mentor a multi-disciplinary group of mentees in patient-oriented research by bridging basic science, clinical and community-based participatory research programs Aim 2: To expand the candidate's clinical research program `Infection Prevention in Aging' in directions that create new and innovative opportunities for her and her mentees The candidate's research brings together expertise in geriatrics and aging research, microbiology and infectious diseases, epidemiology, outcomes research, nursing and others. Her work on reducing infections and antimicrobial resistance in vulnerable populations grows out of work originally funded by NIA, AHRQ, T. Franklin Williams Scholarship (now known as GEMSSTAR) and the Hartford foundation. Three federally funded grants will serve as the platform for this grant proposal: an NIA funded RO1 grant: "Targeted Infection Control Program (TIP) to reduce antimicrobial resistance and infections in Nursing Homes", NIA funded concurrent RO1: "Pathway from functional disability to antimicrobial resistance in Nursing Homes" and an AHRQ award: `AHRQ Safety Program for long-term care: CAUTI'. These federally funded studies have created rich datasets and banked microbes that will be utilized to train mentees in patient-oriented research with extensions to molecular epidemiology and community-based participatory research. Resources supporting the training and development include the MICHR, University of Michigan Pepper Center, UM School of Public Health, UM Patient Safety Enhancement Program (PSEP), and UM Host Microbiome Initiative.

描述（由申请人提供）：候选人的职业目标是制定一项全国和国际知名的“老龄化感染预防”计划。候选人将通过开展以患者为中心的研究来实现这一目标，以改善传染病的结果并降低抗菌素耐药性。候选人的大部分职业生涯都奉献给了弱势老年人口，并培训了由学生、住院医生、研究员、护士调查员和初级教员组成的多学科小组，他们希望在感染预防方面进行以患者为导向的结果研究。开展以患者为中心的感染预防研究，建立稳定的研究经费，并在全国范围内组织许多老龄化研究的职业发展计划，将研究成果转化为临床实践，特别是在疗养院中，是一项具有挑战性的工作。在机构环境中接受护理是导致不良结果的风险特别高的一个因素，培训多学科的初级研究人员小组是设计基于证据的随机研究的关键，以测试减少疗养院感染和抗菌药物耐药性的创新模型和实践。该提案的目标是：目标1：通过连接基础科学、临床和社区参与性研究项目，提高候选人有效指导多学科受训者小组进行以患者为导向的研究的能力。目标 2：扩大候选人的临床研究项目“老龄化感染预防” ” 的方向为她和她的学员创造新的和创新的机会。候选人的研究汇集了老年病学和衰老研究、微生物学和传染病、流行病学、结果研究、护理和她在减少弱势群体感染和抗菌素耐药性方面的工作最初由 NIA、AHRQ、T. Franklin Williams 奖学金（现称为 GEMSSTAR）和哈特福德基金会资助，三项资助将作为该基金会的平台。本拨款提案：NIA 资助的 RO1 拨款：“有针对性的感染控制计划 (TIP)，以减少疗养院的抗菌药物耐药性和感染”，NIA 资助的同时 RO1：“从功能性残疾到康复的途径”疗养院的抗菌药物耐药性”和 AHRQ 奖项：“AHRQ 长期护理安全计划：CAUTI”。这些联邦政府资助的研究创建了丰富的数据集和微生物库，将用于培训学员进行以患者为导向的研究，并扩展到支持培训和发展的资源包括 MICHR、密歇根大学胡椒中心、密歇根大学公共卫生学院、密歇根大学患者安全增强计划。（PSEP）和密歇根大学宿主微生物组计划。