Bioinformatics Core

生物信息学核心

• 批准号: 9233747
• 负责人: Manuel Garber
• 金额: $ 9.04万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9233747
• 关键词: Animals; Back; Bioinformatics; Collaborations; Data; Data Set; Databases; Development; Ensure; Fostering; Genes; Genome; Genomics; Genotype; Germ Cells; Grant; Imagery; Laboratories; Libraries; Maintenance; Massachusetts; Metadata; Methods; Mus; Ontology; Process; Quality Control; RNA Interference; RNA Processing; Research; Resource Informatics; Sampling; Services; Small RNA; Standardization; Transcript; Universities; Work; chromatin immunoprecipitation; computerized data processing; data acquisition; data format; data integration; data management; data visualization; differential expression; high throughput analysis; medical schools; member; piRNA; quality assurance; relational database; tool; transcriptome sequencing

Core Summary The bioinformatics core will serve as a data clearinghouse, offering standardized quality assurance, sequence data handling and visualization to all four projects of this grant. By doing so it will ensure compatible and consistent data formats, parameter optimization and centralized storage. Existing UMMS bioinformatics pipelines will be optimized to provide and standardize read alignment, alignment processing (peak calling, transcript assembly, small RNA mapping, etc., enrichment analysis (Gene Ontology enrichments, etc.), and dataset integration (e.g. differential expression of piRNAs in different conditions). The centralized storage, processing and analysis of project data will thus significantly enhance integration between all four project components. Relevance The services provided by the Bioinformatics Core (Core C) are essential to research proposed by all four Projects. The core will provide storage, quality control, and preliminary analysis of high-throughput data from the three experimental projects (I-III), and make this data available to the computational project for in depth study (Project IV).

核心摘要 生物信息学核心将充当数据交换所，提供标准化的质量 保证，序列数据处理和可视化本赠款的所有四个项目。经过 这样做将确保兼容和一致的数据格式，参数优化 和集中存储。现有的UMMS生物信息学管道将被优化为 提供和标准化读取对齐，对齐处理（高峰呼叫，成绩单 组装，小的RNA映射等，富集分析（基因本体学富集， 等）和数据集集成（例如，在不同的 状况）。因此，项目数据的集中存储，处理和分析将 显着增强了所有四个项目组件之间的整合。 关联 生物信息学核心（核心C）提供的服务对于研究至关重要 由所有四个项目提出。核心将提供存储，质量控制和 对三个实验项目（I-III）的高通量数据的初步分析， 并将这些数据用于深入研究的计算项目（项目IV）。