Analysis of age-associated changes in beta cell function and metabolism through live single-cell imaging

通过活体单细胞成像分析与年龄相关的 β 细胞功能和代谢变化

基本信息

批准号：
9324108
负责人：
Dudley William Lamming
金额：
$ 19.13万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9324108
关键词：
Adult Age Aging American Beta Cell Bioenergetics Biological Models Biological Preservation Caloric Restriction Calories Cell Aging Cell physiology Cells Cellular Metabolic Process Data Defect Development Diabetes Mellitus Diet Dietary Proteins Disease Elderly Electrophysiology (science)Energy Intake Functional disorder Genetic Glucose Glucose Metabolism Disorders Goals Gold Health Healthcare Systems Human Impairment Individual Insulin Insulin Resistance Intervention Islets of Langerhans Lead Longevity Macronutrients Nutrition Measurement Metabolic Methods Mitochondria Morbidity - disease rate Mus Nature Non-Insulin-Dependent Diabetes Mellitus Obesity Overweight Pathway interactions Play Population Preparation Prevention approach Production Research Resolution Resveratrol Risk Risk Factors Rodent Role Site Supplementation Testing Work age effect age group aged blood glucose regulation cell age cell type cellular imaging diabetes risk glycemic control imaging modality impaired glucose tolerance improved in vivo insight insulin secretion islet metabolic imaging mitochondrial metabolism mortality mouse model nonhuman primate novel novel strategies optical imaging prevent public health relevance response

项目摘要

DESCRIPTION (provided by applicant): Advancing age is associated with an increased risk of impaired glucose tolerance and the development of type 2 diabetes. Because these disorders are themselves risk factors for diseases associated with significant morbidity and mortality, new approaches to maintain glucose homeostasis in the aged are urgently needed. Although beta cell dysfunction has been implicated as a contributing factor to disordered glucose homeostasis in the aged, the nature of the beta cell defects that emerge in older individuals has not been carefully studied. Thus, the objective of the proposed study is to identify the precise nature of the beta cell defects that emerge with age and obesity, and gain insight as to whether these defects can be mitigated by known interventions that extend healthspan.

描述（由适用提供）：前进的年龄与葡萄糖耐量受损和2型糖尿病的发展的风险增加有关。由于这些疾病本身是与大量发病率和死亡率相关的疾病的危险因素，因此迫切需要在老年内维持葡萄糖稳态的新方法。尽管β细胞功能障碍已被认为是导致老年葡萄糖稳态无序的因素，但尚未仔细研究β细胞缺陷的性质。这是拟议的研究的目的是确定随着年龄和肥胖而出现的β细胞缺陷的确切性质，并了解是否可以通过扩展HealthSpan的已知干预措施来减轻这些缺陷。