Design and development of a mixed reality system for skilled locomotor training in individuals with Parkinson's disease

设计和开发混合现实系统，用于帕金森病患者的熟练运动训练

• 批准号: 9341965
• 负责人: James M. Finley
• 金额: $ 20.63万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-06 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9341965
• 关键词: Address; Adverse effects; Adverse event; Age; Cities; Clinic; Clinical assessments; Communities; Custom; Data; Development; Dropout; Elements; Enhancement Technology; Environment; Equilibrium; Equipment and supply inventories; Esthetics; Failure; Feedback; Focus Groups; Functional disorder; Future; Gait; Goals; Home environment; Human; Human body; Immersion Investigative Technique; Impairment; Individual; Intervention; Knowledge; Lead; Life; Locomotor training; Measures; Mediation; Monitor; Motion; Motor Skills; Movement; Neuronal Plasticity; Parkinson Disease; Participant; Patients; Performance; Physical Rehabilitation; Poaceae; Prevalence; Process; Quality of life; Recruitment Activity; Rehabilitation therapy; Research; Risk; Sampling; Speed; System; Technology; Testing; Time; Training; Walking; Work; base; computer human interaction; cost; design; educational atmosphere; evidence base; experience; fall risk; falls; gait rehabilitation; improved; innovation; interest; intrinsic motivation; motor skill learning; portability; prototype; public health relevance; sensor; skills; skills training; success; tool; treadmill; usability; virtual; virtual reality

Project Summary/Abstract One of the most disabling limitations for individuals with Parkinson’s disease (PD) are impairments that reduce safe walking in the community. Specifically, people with PD demonstrate difficulty in managing the very elements required for independent access to the community such as completing turns, moving smoothly from one terrain to another such as gravel to grass and avoiding and/or managing obstacles. In fact, tripping over obstacles has been identified as the major cause of falls in community-dwelling people with PD. Commonly, rather than dealing with the challenges of walking in the community, individuals with PD may often be resigned to become home-bound and minimize their risk of adverse events in environment thus negatively impacting their quality of life. However, it is now understood that individuals with PD have the capacity for improved performance and learning of motor skills. Additionally, it has been shown that it is particularly important for individuals with PD that the practice environment matches the real-life environment for learning to transfer from the practice environment to the real world. Thus, it is critical to allow individuals with PD to practice advanced walking skills such as turning and obstacle avoidance in real-world scenarios to maximize functional walking ability. Therefore the primary objective of the proposed study is to develop and test a training system that will allow individuals with PD to practice the advanced walking skills necessary for independence in the community. A preliminary study conducted in support of the current proposal demonstrates the feasibility of using the system while walking on a treadmill. Individuals with PD tolerated walking in the immersive environment without any adverse effects. To accomplish the objectives of this proposal, a low-cost, portable, gait training system will be created to facilitate the practice of advanced locomotor skills (e.g. turning, obstacle avoidance, and dual-tasking) for individuals with PD. Importantly, the system will be capable of being used on multiple platforms (standard treadmills, over-ground in an open space, or in conjunction with newer, omni-directional treadmills). During development, a sample of individuals with PD will be recruited to experience and provide feedback on the value and meaningfulness of the training environments. The secondary objective is to determine the feasibility of individuals with PD completing a set of progressive training sessions in the developed environments. Feasibility will be assessed by participant drop-out rate, the prevalence of adverse effects, and the participant’s perceived value of the training environment. This study will result in a new, innovative training approach that will improve skilled locomotor ability in individuals with PD. Furthermore, this study will create a unique, low-cost, and enjoyable system that could be used in the clinic or at home for training and monitoring of movement-related dysfunction.

项目摘要/摘要 帕金森氏病（PD）患者最残疾的局限性之一是减少社区安全行走的障碍。具体而言，患有PD的人很难管理独立进入社区所需的要素，例如完成转弯，从一个地形顺利移动到另一个地形，例如重力到草，避免和/或管理障碍。实际上，绊倒障碍已被确定为居住在PD的社区居民跌倒的主要原因。通常，PD患有PD的人可能会辞职以成为家庭结合并最大程度地降低环境中不良事件的风险，从而对其生活质量产生负面影响。但是，现在已经了解到，患有PD的人具有提高性能和学习运动技能的能力。此外，已经表明，对于患有PD的人来说，实践环境与学习从实践环境转移到现实世界的现实环境特别重要。这一点至关重要的是，允许PD的人在现实世界中练习高级步行技巧，例如转弯和避免障碍物，以最大程度地提高功能性步行能力。因此，拟议的研究的主要目的是开发和测试一种培训系统，该系统将使PD个人能够练习社区独立所必需的先进步行技巧。为支持当前建议的初步研究表明，在跑步机上行走时使用该系统的可行性。 PD的个体在沉浸式环境中耐受行走而没有任何不利影响。为了实现该提案的目标，将创建一个低成本，便携式，一种聚会系统，以促进具有PD个人的高级运动技能（例如转弯，避免障碍和双重任务）的实践。重要的是，该系统将能够在多个平台上使用（标准跑步机，在开放空间中的地面或与较新的Omni方向跑步机一起使用）。在开发过程中，将招募一个患有PD的个体的样本，以体验并提供有关培训环境的价值和有意义性的反馈。次要目标是确定PD个体在发达环境中完成一系列渐进培训课程的可行性。可行性将通过参与者的辍学率，不利影响的流行以及参与者的培训环境价值进行评估。这项研究将导致一种新的创新培训方法，该方法将提高PD患者的熟练运动能力。此外，这项研究将创建一个独特的，低成本且令人愉悦的系统，该系统可在诊所或家里用于培训和监测与运动相关的功能障碍。

项目成果

Design and Development of a Virtual Reality-Based Mobility Training Game for People With Parkinson's Disease.

• DOI: 10.3389/fneur.2020.577713
• 发表时间: 2020
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Finley JM;Gotsis M;Lympouridis V;Jain S;Kim A;Fisher BE
• 通讯作者: Fisher BE

Manipulating the fidelity of lower extremity visual feedback to identify obstacle negotiation strategies in immersive virtual reality.

操纵下肢视觉反馈的保真度来识别沉浸式虚拟现实中的障碍谈判策略。

• DOI: 10.1109/embc.2017.8037854
• 发表时间: 2017
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Kim,Aram;Zhou,Zixuan;Kretch,KariS;Finley,JamesM
• 通讯作者: Finley,JamesM